Concert recording 2021-12-07

[Track 1]. Bien sabroso / Poncho Sanchez ; arranged by Fernando Valencia -- [Track 2]. Come candela / Mongo Santamaría ; arranged by Valendia -- [Track 3]. Philly mambo / Tito Puente -- [Track 4]. Como la flor / Ricardo Vela ; arranged by Valencia -- [Track 5]. Maria Cervantes / Noro Morales ; arranged by Valencia -- [Track 6]. Afro blue / Mongo Santamaría -- [Track 7]. Get up and dance / James Joseph

Concert recording 2018-11-13

[Track 1]. Douzes etudes pour Caisse Claire. No. 1 / Jacques Delecluse -- [Track 2]. Ghost garden / Adam Hopper -- [Track 3]. Rotation no. 4 / Eric Sammut -- [Track 4]. Nine French-American rudimental solos. No. 6 / Unknown -- [Track 5]. Advanced studies for snare drum. No. 3 / Mitchell Peters -- [Track 6]. Tempest / Todd Ukena -- [Track 7]. Excerpt from Northern lights / Eric Ewazen -- [Track 8]. Caleidoscópio / Gene Koschinksi -- [Track 9]. Advanced studies for snare drum. No. 1 / Peters -- [Track 10]. Sweet dreams from Album for the young / Tchaikovsky arranged by L.H. Stevens -- [Track 11]. Furioso and valse in D minor / Earl Hatch -- [Track 12]. Pratt\u27s taps / William Schinstine -- [Track 13]. Max / J.C. Combs -- [Track 14]. Raga no. 1 / William Cahn -- [Track 15]. Sechs Miniaturen. No. 3 / Matthias Schmitt -- [Track 16]. Eden / Adam Miller -- [Track 17]. Four pieces for timpani. Mvts. 3 & 4 / John Bergamo -- [Track 18]. Swerve / Gene Kaschinski -- [Track 19]. White knuckle stroll / Casey Cangelosi -- [Track 20]. Evergreen / Benjamin Finley -- [Track 21]. Time remembered / Branden Steinmetz

Concert recording 2019-04-16

[Track 1]. Rotation #2 / Eric Sammut -- [Track 2]. Pines of Rome mvt 1 / Ottorino Respighi -- [Track 3]. Chart #2 / Fernando Valencia -- [Track 4]. Chopstakovich / Jesse Sieff -- [Track 5]. Drei Skizzen mvt. III / Matthias Schmitt -- [Track 6]. Sonata no. 1 for G in violoncello. Prelude [Track 7]. Sarabande [Track 8]. Courante / J.S. Bach -- [Track 9]. #1 from Douze Etudes / Jacques Delecluse -- [Track 10]. The offering / Michael Burritt -- [Track 11]. Prelude and blues / Ney Rosauro -- [Track 12]. Danny boy / traditional arranged by Brian Mueller -- [Track 13]. Ransom / Mark Ford -- [Track 14]. Sonata for timpani mvt III / John Beck -- [Track 15]. Dr. Gradus ad Parnassum / Claude Debussy arranged by Paul Bissell -- [Track 16]. Etude #1 / Vic Firth -- [Track 17]. Highlights from Northern lights / Eric Ewazen -- [Track 18]. Jesus loves me / Chad Floyd -- [Track 19]. Faded lines / Andrea Venet - [Track 20]. Triplets / George Hamilton Green arranged by Bob Becker -- [Track 21]. Girlfriends medley / Bob Becker -- [Track 22]. Selections from Oru Secu. Guaguancó [Track 23]. Guarapachangueo / Traditional trans. Valencia

Mortality gap for people with bipolar disorder and schizophrenia: UK-based cohort study 2000–2014

BACKGROUND: Bipolar disorder and schizophrenia are associated with increased mortality relative to the general population. There is an international emphasis on decreasing this excess mortality. AIMS: To determine whether the mortality gap between individuals with bipolar disorder and schizophrenia and the general population has decreased. METHOD: A nationally representative cohort study using primary care electronic health records from 2000 to 2014, comparing all patients diagnosed with bipolar disorder or schizophrenia and the general population. The primary outcome was all-cause mortality. RESULTS: Individuals with bipolar disorder and schizophrenia had elevated mortality (adjusted hazard ratio (HR) = 1.79, 95% CI 1.67-1.88 and 2.08, 95% CI 1.98-2.19 respectively). Adjusted HRs for bipolar disorder increased by 0.14/year (95% CI 0.10-0.19) from 2006 to 2014. The adjusted HRs for schizophrenia increased gradually from 2004 to 2010 (0.11/year, 95% CI 0.04-0.17) and rapidly after 2010 (0.34/year, 95% CI 0.18-0.49). CONCLUSIONS: The mortality gap between individuals with bipolar disorder and schizophrenia, and the general population is widening

A sequence analysis of patterns in self-harm in young people with and without experience of being looked-after in care

Objectives: Young people in the public care system (‘looked-after’ young people) have high levels of self-harm. Design: This paper reports the first detailed study of factors leading to self-harm over time in looked-after young people in England, using sequence analyses of the Card Sort Task for Self-harm (CaTS). Methods: Young people in care (looked-after group: n = 24; 14-21 years) and young people who had never been in care (contrast group: n = 21; 13-21 years) completed the CaTS, describing sequences of factors leading to their first and most recent episodes of self-harm. Lag sequential analysis determined patterns of significant transitions between factors (thoughts, feelings, behaviours, events) leading to self-harm across six months. Results: Young people in care reported feeling better immediately following their first episode of self-harm. However, fearlessness of death, impulsivity and access to means were reported most proximal to recent self-harm. Although difficult negative emotions were salient to self-harm sequences in both groups, young people with no experience of being in care reported a greater range of negative emotions and transitions between them. For the contrast group, feelings of depression and sadness were a significant starting point of the self-harm sequence six months prior to most recent self-harm. Conclusions: Sequences of factors leading to self-harm can change and evolve over time, so regular monitoring and assessment of each self-harm episode is needed. Support around easing and dealing with emotional distress is required. Restricting access to means to carry out potentially fatal self-harm attempts, particularly for the young persons with experience of being in care, is recommended

New insights into HIV-1-primary skin disorders

Since the first reports of AIDS, skin involvement has become a burdensome stigma for seropositive patients and a challenging task for dermatologist and infectious disease specialists due to the severe and recalcitrant nature of the conditions. Dermatologic manifestations in AIDS patients act as markers of disease progression, a fact that enhances the importance of understanding their pathogenesis

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

The immune response in the brain has been widely investigated and while many studies have focused on the proinflammatory cytotoxic response, the brain’s innate immune system demonstrates significant heterogeneity. Microglia, like other tissue macrophages, participate in repair and resolution processes after infection or injury to restore normal tissue homeostasis. This review examines the mechanisms that lead to reduction of self-toxicity and to repair and restructuring of the damaged extracellular matrix in the brain. Part of the resolution process involves switching macrophage functional activation to include reduction of proinflammatory mediators, increased production and release of anti-inflammatory cytokines, and production of cytoactive factors involved in repair and reconstruction of the damaged brain. Two partially overlapping and complimentary functional macrophage states have been identified and are called alternative activation and acquired deactivation. The immunosuppressive and repair processes of each of these states and how alternative activation and acquired deactivation participate in chronic neuroinflammation in the brain are discussed

Transient receptor potential channels in Alzheimer's disease

AbstractCognitive impairment and emotional disturbances in Alzheimer's disease (AD) result from the degeneration of synapses and neuronal death in the limbic system and associated regions of the cerebral cortex. An alteration in the proteolytic processing of the amyloid precursor protein (APP) results in increased production and accumulation of amyloid β-peptide (Aβ) in the brain. Aβ can render neurons vulnerable to excitotoxicity and apoptosis by disruption of cellular Ca2+ homeostasis and neurotoxic factors including reactive oxygen species (ROS), nitric oxide (NO), and cytokines. Many lines of evidence have suggested that transient receptor potential (TRP) channels consisting of six main subfamilies termed the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), and TRPA (ankyrin) are involved in Ca2+ homeostasis disruption. Thus, emerging evidence of the pathophysiological role of TRP channels has yielded promising candidates for molecular entities mediating Ca2+ homeostasis disruption in AD. In this review, we focus on the TRP channels in AD and highlight some TRP “suspects” for which a role in AD can be anticipated. An understanding of the involvement of TRP channels in AD may lead to the development of new target therapies

We're in this Together: Sensation of the Host Cell Environment by Endosymbiotic Bacteria

Bacteria inhabit diverse environments, including the inside of eukaryotic cells. While a bacterial invader may initially act as a parasite or pathogen, a subsequent mutualistic relationship can emerge in which the endosymbiotic bacteria and their host share metabolites. While the environment of the host cell provides improved stability when compared to an extracellular environment, the endosymbiont population must still cope with changing conditions, including variable nutrient concentrations, the host cell cycle, host developmental programs, and host genetic variation. Furthermore, the eukaryotic host can deploy mechanisms actively preventing a bacterial return to a pathogenic state. Many endosymbionts are likely to use two-component systems (TCSs) to sense their surroundings, and expanded genomic studies of endosymbionts should reveal how TCSs may promote bacterial integration with a host cell. We suggest that studying TCS maintenance or loss may be informative about the evolutionary pathway taken toward endosymbiosis, or even toward endosymbiont-to-organelle conversion.Peer reviewe