A cluster analysis approach to sampling domestic properties for sensor deployment

This is the final version. Available on open access from Elsevier via the DOI in this recordData availability: Data will be made available on request.Sensors are an increasingly widespread tool for monitoring utility usage (e.g., electricity) and environmental data (e.g., temperature). In large-scale projects, it is often impractical and sometimes impossible to place sensors at all sites of interest, for example due to limited sensor numbers or access. We test whether cluster analysis can be used to address this problem. We create clusters of potential sensor sites using factors that may influence sensor measurements. The clusters provide groups of sites that are similar to each other, and that differ between groups. Sampling a few sites from each group provides a subset that captures the diversity of sites. We test the approach with two types of sensors: utility usage (gas and water) and outdoor environment. Using a separate analysis for each sensor type, we create clusters using characteristics from up to 298 potential sites. We sample across these clusters to provide representative coverage for sensor installations. We verify the approach using data from the sensors installed as a result of the sampling, as well as using other sensor measures from all available sites over one year. Results show that sensor data vary across clusters, and vary with the factors used to create the clusters, thereby providing evidence that this cluster-based approach captures differences across sensor sites. This novel methodology provides representative sampling across potential sensor sites. It is generalisable to other sensor types and to any situation in which influencing factors at potential sites are known. We also discuss recommendations for future sensor-based large-scale projects.European Regional Development Fund (ERDF)Southwest Academic Health Science NetworkCornwall Counci

Immunomodulation in the treatment and/or prevention of bronchial asthma

ABSTRACTThe immunologic hallmark of atopic allergy and asthma is an increased production of IgE and T helper (h) type 2 cell cytokines (interleukin (IL)-4, IL-5, IL-9 and IL-13) by Th cells reacting to common environmental allergens. All of us inhale allergens and healthy non-atopics produce allergen-specific IgG1, IgG4 and the Th1 cytokine interferon-α, as well as IL-12 from macrophages. We now have many modalities of immunomodulation to decrease the effect of IL-4 or IL-5 or production and level of IgE or agents to shift the immune response from a Th2 to a Th1 response, thereby decreasing the allergic inflammatory response in the airways. In the present review we focus on conventional immunotherapy, mycobacterial vaccines, DNA vaccines using cytosine guanosine, inhibitors of IL-4 and IL-5 and anti-IgE: Omalizumab

Modelling mould growth in domestic environments using relative humidity and temperature

This is the final version. Available from Elsevier via the DOI in this record. Damp and high levels of relative humidity (RH), typically above 70–80%, are known to provide mould-favourable conditions. Exposure to indoor mould contamination has been associated with an increased risk of developing and/or exacerbating a range of allergic and non-allergic diseases. The VTT model is a mathematical model of indoor mould growth that was developed based on surface readings of RH and temperature on wood in a controlled laboratory chamber. The model provides a mould index based on the environmental readings. We test the generalisability of this laboratory-based model to less-controlled domestic environments across different values of model parameters. Mould indices were generated using objective measurements of RH and temperature in the air, taken from sensors in a domestic setting every 3–5 min over 1 year in the living room and bedroom across 219 homes. Mould indices were assessed against self-reports from occupants regarding the presence of visible mould growth and mouldy odour in the home. Logistic regression provided evidence for relationships between mould indices and occupant responses. Mould indices were most successful at predicting occupant responses when the model parameters encouraged higher vulnerability to mould growth compared with the original VTT model. A lower critical RH level, above which mould grows, a higher sensitivity, and larger increases in the mould index all consistently increased performance. Using moment-to-moment time-series data for temperature and RH, the model and its developments could help inform smart monitoring or control of RH, for example to counter risks associated with reduced ventilation in energy efficient homes.European Regional Development Fund (ERDF)European Regional Development Fund (ERDF

The role of particle, energy and momentum losses in 1D simulations of divertor detachment

A new 1D divertor plasma code, SD1D, has been used to examine the role of recombination, radiation, and momentum exchange in detachment. Neither momentum or power losses by themselves are found to be sufficient to produce a reduction in target ion flux in detachment (flux rollover); radiative power losses are required to a) limit and reduce the ionization source and b) access low-target temperature, T_target, conditions for volumetric momentum losses. Recombination is found to play little role at flux rollover, but as T_target drops to temperatures around 1eV, it becomes a strong ion sink. In the case where radiative losses are dominated by hydrogen, the detachment threshold is identified as a minimum gradient of the energy cost per ionisation with respect to T_target. This is also linked to thresholds in T_target and in the ratio of upstream pressure to power flux. A system of determining the detached condition is developed such that the divertor solution at a given T_target (or lack of one) is determined by the simultaneous solution of two equations for target ion current - one dependent on power losses and the other on momentum. Depending on the detailed momentum and power loss dependence on temperature there are regions of T_target where there is no solution and the plasma 'jumps' from high to low T_target states. The novel analysis methods developed here provide an intuitive way to understand complex detachment phenomena, and can potentially be used to predict how changes in the seeding impurity used or recycling aspects of the divertor can be utilised to modify the development of detachment

The role of particle, energy and momentum losses in 1D simulations of divertor detachment

A new 1D divertor plasma code, SD1D, has been used to examine the role of recombination, radiation, and momentum exchange in detachment. Neither momentum or power losses by themselves are found to be sufficient to produce a reduction in target ion flux in detachment (flux rollover); radiative power losses are required to a) limit and reduce the ionization source and b) access low-target temperature, T_target, conditions for volumetric momentum losses. Recombination is found to play little role at flux rollover, but as T_target drops to temperatures around 1eV, it becomes a strong ion sink. In the case where radiative losses are dominated by hydrogen, the detachment threshold is identified as a minimum gradient of the energy cost per ionisation with respect to T_target. This is also linked to thresholds in T_target and in the ratio of upstream pressure to power flux. A system of determining the detached condition is developed such that the divertor solution at a given T_target (or lack of one) is determined by the simultaneous solution of two equations for target ion current - one dependent on power losses and the other on momentum. Depending on the detailed momentum and power loss dependence on temperature there are regions of T_target where there is no solution and the plasma 'jumps' from high to low T_target states. The novel analysis methods developed here provide an intuitive way to understand complex detachment phenomena, and can potentially be used to predict how changes in the seeding impurity used or recycling aspects of the divertor can be utilised to modify the development of detachment

Combinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development

Heparan sulfate proteoglycans (HSPGs) play critical roles in the development and adult physiology of all metazoan organisms. Most of the known molecular interactions of HSPGs are attributed to the structurally highly complex heparan sulfate (HS) glycans. However, whether a specific HSPG (such as syndecan) contains HS modifications that differ from another HSPG (such as glypican) has remained largely unresolved. Here, a neural model in C. elegans is used to demonstrate for the first time the relationship between specific HSPGs and HS modifications in a defined biological process in vivo. HSPGs are critical for the migration of hermaphrodite specific neurons (HSNs) as genetic elimination of multiple HSPGs leads to 80% defect of HSN migration. The effects of genetic elimination of HSPGs are additive, suggesting that multiple HSPGs, present in the migrating neuron and in the matrix, act in parallel to support neuron migration. Genetic analyses suggest that syndecan/sdn-1 and HS 6-O-sulfotransferase, hst-6, function in a linear signaling pathway and glypican/lon-2 and HS 2-O-sulfotransferase, hst-2, function together in a pathway that is parallel to sdn-1 and hst-6. These results suggest core protein specific HS modifications that are critical for HSN migration. In C. elegans, the core protein specificity of distinct HS modifications may be in part regulated at the level of tissue specific expression of genes encoding for HSPGs and HS modifying enzymes. Genetic analysis reveals that there is a delicate balance of HS modifications and eliminating one HS modifying enzyme in a compromised genetic background leads to significant changes in the overall phenotype. These findings are of importance with the view of HS as a critical regulator of cell signaling in normal development and disease

Evaluating the current state of evolution acceptance instruments: a research coordination network meeting report

Hundreds of studies have explored student evolution acceptance because evolution is a core concept of biology that many undergraduate biology students struggle to accept. However, this construct of “evolution acceptance” has been defined and measured in various ways, which has led to inconsistencies across studies and difficulties in comparing results from different studies. Many studies and essays have offered evaluations and perspectives of evolution acceptance instruments, but publications with a focus on consensus building across research teams is still needed. Further, little attention has been paid to how evolution acceptance instruments may be interpreted differently by students with varied religious backgrounds. Funded by a Research Coordination Network in Undergraduate Biology Education grant from the National Science Foundation, we gathered 16 experts from different disciplinary and religious backgrounds to review current evolution acceptance instruments and create a guide to the strengths and weaknesses of these instruments, including appropriate contexts for using these instruments and their potential weaknesses with different religious populations. Finally, in an attempt to move the field forward, we articulated a consensus definition of evolution acceptance that can be used to guide future instrument development

The employee as 'Dish of the Day’:human resource management and the ethics of consumption

This article examines the ethical implications of the growing integration of consumption into the heart of the employment relationship. Human resource management (HRM) practices increasingly draw upon the values and practices of consumption, constructing employees as the ‘consumers’ of ‘cafeteria-style’ benefits and development opportunities. However, at the same time employees are expected to market themselves as items to be consumed on a corporate menu. In relation to this simultaneous position of consumer/consumed, the employee is expected to actively engage in the commodification of themselves, performing an appropriate organizational identity as a necessary part of being a successful employee. This article argues that the relationship between HRM and the simultaneously consuming/consumed employee affects the conditions of possibility for ethical relations within organizational life. It is argued that the underlying ‘ethos’ for the integration of consumption values into HRM practices encourages a self-reflecting, self-absorbed subject, drawing upon a narrow view of individualised autonomy and choice. Referring to Levinas’ perspective that the primary ethical relation is that of responsibility and openness to the Other, it is concluded that these HRM practices affect the possibility for ethical being

Current trends in the surgical management of Dupuytren’s disease in Europe: an analysis of patient charts

Introduction: Dupuytren's disease (DD) causes progressive digital flexion contracture and is more common in men of European descent. Methods: Orthopaedic and plastic surgeons in 12 European countries (the Czech Republic, Denmark, Finland, France, Germany, Hungary, Italy, The Netherlands, Poland, Spain, Sweden and the UK) with >3 and <30 years experience reviewed the medical charts of five consecutive patients they had treated surgically for DD in 2008. Descriptive statistics are reported. Results: In total, 3,357 patient charts were reviewed. Mean (standard deviation) patient age was 61.9 (10.2) years; 81% were men. At the time of the procedure, 11% of patients were at Tubiana stage Ia (0-20° total flexion); 30%, stage Ib (21-45°); 34%, stage II (46-90°); 17%, stage III (91-135°); and 5%, stage IV (&135°). Percutaneous needle fasciotomy was performed in 10%, fasciotomy in 13%, fasciectomy in 69% and dermofasciectomy (DF) in 6% of patients. After surgery, fingers improved a mean of 1.9 Tubiana stages, and 54% of patients had no nodules or contracture. The rate of reported complications during the procedure was 4% overall (11% in patients undergoing DF). The most common postoperative complications reported were haematoma (8%), wound healing complications (6%) and pain (6%). No postoperative complications were reported in 77% of patients. Conclusions: In this European study of more than 3,000 patients with DD, most patients were diagnosed at Tubiana stage I or II, the majority received fasciectomy and more than half had no nodules or contracture remaining after surgery