3 research outputs found
Odd random phase multisine EIS as a detection method for the onset of corrosion of coated steel
In this work, odd random phase multisine Electrochemical Impedance Spectroscopy (ORP-EIS) was used as a detection method for the onset of corrosion of coated steel. The possibility to use ORP-EIS as a rapid-screening test for corrosion was investigated. It is concluded that the detection of a non-linear behavior combined with a non-stationary behavior during the onset of corrosion can be used as a criterion in a rapid-screening test for corrosion of coated steel. Keywords: Corrosion, Electrochemical impedance, Odd random phase multisine, Rapid-screening test, Non-stationary behavior, Non-linear behavio
Synthesis of the diastereomers of β-Me-Tyr and β-Me-Phe and their effect on the biological properties of the delta opioid receptor antagonist TIPP
In order to influence side-chain conformations and to increase the μ-agonist properties of the δ-selective opioid receptor δ-antagonist H-Tyr-Tic-Phe-Phe-NH2, residues Tyr1, Phe3 and Phe4 were replaced by their β-methyl-substituted stereoisomers. Synthesis of β-Me-Tyr was carried out in a stereoselective way. Incorporation of the modified amino acids was performed by SPPS. Receptor binding data and GPI and MVD bioassays were obtained for all stereoisomers, in general showing equal or slightly increased potencies. In the [(R,S)β-Me-Phe3]analogue, the introduction of the β-methyl substituent restores signal transduction. © 1995 ESCOM Science Publishers B.V.SCOPUS: ar.jinfo:eu-repo/semantics/publishe