4 research outputs found
Conformational Restriction Leading to a Selective CB 2
- Author
- Publication venue
- 'American Chemical Society (ACS)'
- Publication date
- 04/12/2014
- Field of study
The CB2 cannabinoid receptor has been implicated in the regulation of intestinal inflammation. Following on from the promising activity of a series of 4-oxo-1,4-dihydroquinoline-3-carboxamide, we developed constrained analogues based on a 2H-pyrazolo[4,3-c]quinolin-3(5H)-one scaffold, with improved affinity for the hCB2 receptor and had very high selectivity over the hCB1 receptor. Importantly, the lead of this series (26, hCB2: K i = 0.39 nM, hCB1: K i > 3000 nM) was found to protect mice against experimental colitis after oral administration
Sepsis 2016 Paris : Paris, France. 6-8 December 2016
- Author
- Ahmetaj-Shala Blerina
- Alberici Luciane C.
- Anderko Renee R.
- Angus Derek C.
- Baier CĂ©line
- Barreca Giorgio Settimo
- Bazus Hélène
- Bedova Aleksandra
- Beloborodova Natalia
- Bhikoo Raisa
- Bhurayanontachai Rungsun
- Bonten M. J M
- Bonten M. J M
- Brunet Corinne
- Carcillo Joseph A.
- CatalĂŁo Carlos Henrique R
- Chan Hung
- Chan Matthew T V
- Chhibber Sanjay
- Choi Gordon
- Colle Julien
- Costa Luis Henrique A
- Costello RĂ©gis
- Cremer O. L.
- Cremer O. L.
- Crowfoot Gary
- Cuvier Valérie
- De Meester Ingrid
- Derive Marc
- Farnault Laure
- Fernandez-Nunez Nicloas
- Filali Amel
- FocĂ Alfredo
- Franci Celso Rodrigues
- Fransen Erik
- Frencken J. F.
- Frencken J. F.
- Galati Luisa
- Garaud Jean Jacques
- GarcĂa-González Victor
- Gashaw Hime
- Giancotti Aida
- Gibot SĂ©bastien
- Gin Tony
- Gisbertz S. S.
- Giusti Humberto
- Grachev Sergey
- Gray DNicola N.
- Henegouwen M. I van Berge
- HO Jeffery
- Ingles Marcia
- Jackson Vanessa M.
- Jorens Philippe G.
- Kabanov Dmitry
- Kehoe Kaat
- Kellum John A.
- Khwannimit Bodin
- Kirkby Nicholas
- Klouwenberg P. M C Klein
- Koster-Brouwer M. E.
- Kumar Vijay
- Kuzovlev Artem N.
- Kwong Thomas
- Labiad Yasmine
- Lambeir Anne Marie
- Lee Ji Young
- Leiper James
- Liberto Maria Carla
- Lin Ke
- Linge Helena M.
- Liu Shu Fang
- Liu Xiaodong
- Loriod BĂ©atrice
- MacCallum Niall
- Mallat Jihad
- Mas-Oliva Jaime
- Masse Juliette
- Matera Giovanni
- Mattei Jean Camille
- Miller Edmund J.
- Mitchell Jane A.
- Mumby Sharon
- Nevado Jose B.
- Nguyen Catherine
- Nigeon Olivier
- Obraztsov Igor
- Ochani Kanta
- Osipov Artem
- Palmer Octavia M Peck
- Pautova Alisa
- Peronace Cinzia
- Peters Esther
- Pickkers Peter
- Prokhorenko Isabella
- Quinlan Gregory
- Quirino Angela
- Ribeiro Aline Barbosa
- Rihet Pascal
- Rocha Maria José A
- Ruurda J. P.
- Saia Rafael Simone
- Salcedo Margarita
- Salnikova Lubov E.
- Santos Jerico R.
- Santos-JĂşnior Nilton N.
- Scicluna B.
- Sevillejal Jesus Emmanuel A D
- Singhal Pravin C.
- Smelaya Tamara V.
- Souza Ana Paula Trevelin
- Souza Anderson O.
- Suchon Pierre
- Sukhina Marina
- Sukhina Marina A.
- Tembhre Manoj
- Tesfai Abel
- Thevenin Didier
- Tourteau Emilie
- van de Groep K.
- van der Poll T.
- van der Poll T.
- van Grunderbeeck Nicolas
- van Hillegersberg R.
- Vattanavanit Veerapong
- Venton Geoffroy
- Verboom D. M.
- Verboom D. M.
- Verkerk Robert
- Vliegen Gwendolyn
- Wang Ping
- Witte Stephan
- Wong Sunny H.
- Wu William K K
- Zhang Lin
- Zhukhovitskiy Vladimir
- Zhukhovitskiy Vladimir G.
- Zubova Svetlana
- Publication venue
- Publication date
- 06/12/2016
- Field of study
Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer’s Disease and Less Well-Known Diseases
- Author
- Aghazadeh Tabrizi M.
- Aghazadeh Tabrizi M.
- Ahmed A.
- Aizpurua-Olaizola O.
- Alexander S.P.
- Ashton J.C.
- Aso E.
- Aso E.
- Aso E.
- Aso E.
- Bab I.
- Bajda M.
- Baraldi P.G.
- Bari M.
- Barth F.
- Basu S.
- Bedse G.
- Bell M.R.
- Benito C.
- Bifulco M.
- Bingham B.
- Bisogno T.
- Bravo-Ferrer I.
- Bátkai S.
- Cabral G.A.
- Callén L.
- Campillo N.E.
- Cao C.
- Carbone F.
- Carbone F.
- Casarejos M.J.
- Cassano T.
- Centonze D.
- Chen B.
- Chen R.
- Cheng Y.
- Cheng Y.
- Cheng Y.X.
- Childers S.R.
- Chiu C.Q.
- ChiurchiĂą V.
- Cianchi F.
- Claassen J.A.
- Coulthard E.
- Croci T.
- Defer N.
- Devane W.A.
- Devane W.A.
- Di Filippo C.
- Di Marzo V.
- Di Marzo V.
- Di Marzo V.
- Di Marzo V.
- Diaz P.
- DiMauro E.F.
- Dolles D.
- D’Ambra T.E.
- Eatherton A.J.
- Ehrhart J.
- El Bakali J.
- El Bakali J.
- Eljaschewitsch E.
- Elsabbagh M.
- ElSohly M.A.
- Elsohly M.A.
- Ermann M.
- Esposito G.
- Esposito G.
- Esposito G.
- Esposito G.
- Eubanks L.M.
- Fakhfouri G.
- Fasinu P.S.
- Felder C.C.
- Fernández-López D.
- Fernández-Ruiz J.
- Fernández-Ruiz J.
- Ferrer I.
- Fong T.M.
- Franklin J.M.
- Frost J.M.
- Gallant M.D.C.
- Gaoni Y.
- Gareau Y.
- Gertsch J.
- Giblin G.M.
- Gijsen H.J.
- Glass M.
- Gleave R.J.
- Gleave R.J.
- Gonsiorek W.
- Gonzalez A.
- González-Naranjo P.
- González-Naranjo P.
- Goodman A.J.
- Govaerts S.J.
- Greenshaw A.J.
- Grigorenko E.
- Guzior N.
- Habib S.S.
- Han S.
- Hanus L.
- Hanus L.
- Haugh O.
- Herkenham M.
- Herkenham M.
- Herkenham M.
- Hill A.J.
- Hillard C.J.
- Hillard C.J.
- Hillard C.J.
- Hollinshead S.P.
- Hollinshead S.P.
- Horti A.G.
- Horváth B.
- Howlett A.C.
- Howlett A.C.
- Howlett A.C.
- Howlett A.C.
- Hu B.
- Huffman J.W.
- Huffman J.W.
- Huffman J.W.
- Hynes J.
- Ibrahim M.M.
- Ibsen M.S.
- Iuvone T.
- Iwamura H.
- Iwata Y.
- Janefjord E.
- Jiang H.E.
- Joyeux M.
- Juan A. Páez
- Järbe T.U.
- Kai H.
- Kai H.
- Kalogeris T.
- Kaschina E.
- Kaur R.
- Khanolkar A.D.
- Khurana L.
- Kini U.N.
- Klafki H.W.
- Koppel J.
- Krylatov A.V.
- Lagneux C.
- Li H.L.
- Li H.L.
- Li Q.
- Libby P.
- Libby P.
- Libro R.
- Little P.J.
- Little P.J.
- Lozano I.
- Lucchesi V.
- Lunn C.A.
- LĂ©picier P.
- Maccarrone M.
- Maccarrone M.
- Maccarrone M.
- Maccarrone M.
- Mach F.
- Makriyannis A.
- Malan T.P.
- Manera C.
- Manera C.
- Manera C.
- Manera C.
- Manera C.
- Manley P.J.
- Marriott K.S.
- MartĂn-Moreno A.M.
- MartĂn-Moreno A.M.
- Marx I.E.
- Matsuda L.A.
- McLaren J.E.
- McPartland J.
- Mechoulam R.
- Mechoulam R.
- Mechoulam R.
- Mechoulam R.
- Mendizábal V.E.
- Miller A.M.
- Milton N.G.
- Mitchell W.L.
- Montecucco F.
- Morales P.
- Moreno E.
- Mukhopadhyay P.
- Mukhopadhyay P.
- Mulder J.
- Munro S.
- Murikinati S.
- Nanda K.K.
- Nasehi M.
- Navarro-Dorado J.
- Nimczick M.
- Nuria E. Campillo
- Odan M.
- Ofek O.
- Ohta H.
- Ohta H.
- Ohta H.
- O’Shaughnessy W.B.
- O’Sullivan S.E.
- Pacher P.
- Pacher P.
- Pagé D.
- Pasquini S.
- Pertwee R.
- Pertwee R.G.
- Pertwee R.G.
- Pertwee R.G.
- Pertwee R.G.
- Pistis M.
- Porter A.C.
- Poso A.
- Páez J. A.
- PĂ©rez D.I.
- Qian H.Y.
- RamĂrez B.G.
- Ranieri R.
- Riether D.
- Rinaldi-Carmona M.
- Ross R.A.
- Russo E.B.
- Ryckmans T.
- Sharma M.K.
- Sharma M.K.
- Sheng W.S.
- Shire D.
- Showalter V.M.
- Silvestri C.
- Smoum R.
- Solas M.
- Solinas M.
- Spinelli F.
- Spoto B.
- Steffens S.
- Steffens S.
- Stern E.
- Sugiura T.
- Sugiura T.
- SvĂzenská I.
- Swirski F.K.
- Szabo B.
- Tam J.
- Thomas A.
- Thomas A.
- Thomas S.J.
- TolĂłn R.M.
- Tourteau A.
- Touw M.
- Trotter B.W.
- Turcotte C.
- Valenzano K.J.
- van der Stelt M.
- Van Sickle M.D.
- Vandevoorde S.
- Verbist B.M.
- Villarroya M.
- Vincenzi F.
- Viñals X.
- Wagner J.A.
- Wang L.
- Wang P.F.
- Wang Y.
- Watson C.
- Weissman A.
- Wiley J.L.
- Willecke F.
- Worm K.
- Wu J.
- Yang S.W.
- Yao B.B.
- Yrjölä S.
- Yrjölä S.
- Zamberletti E.
- Zarruk J.G.
- Zhang M.
- Zhang M.
- Zhao Y.
- Zimmer A.
- Zindell R.
- Zindell R.
- Zoppi S.
- Zubrzycki M.
- Publication venue
- 'Bentham Science Publishers Ltd.'
- Publication date
- Field of study
The CB2 receptor and its role as a regulator of inflammation
- Author
- A Klegeris
- A Shiratsuchi
- A Sophocleous
- A Tourteau
- AC Schmole
- AF Bento
- AH Taylor
- AH Taylor
- AJ Sanchez Lopez
- AL Small-Howard
- AN Akopian
- AR Schatz
- AV Derbenev
- AV Stempel
- B Csoka
- B Gardner
- BF Thomas
- BK Atwood
- C Costola-de-Souza
- C Filippo Di
- C Manera
- C Netherland-Van Dyke
- C Turcotte
- C Zoratti
- CA Newton
- CA Rouzer
- Caroline Turcotte
- CC Felder
- CD Netherland
- D Richardson
- D Shire
- D Ziring
- DG Demuth
- DJ Delsing
- DK Galanakis
- E Eljaschewitsch
- E Gkoumassi
- E Krustev
- E Ryberg
- EA Romero-Sandoval
- ED Giudice
- ED Harris Jr
- ES Graham
- ES Raborn
- F Borrelli
- F Chouinard
- F Chouinard
- F Comelli
- F Correa
- F Correa
- F Correa
- F Fezza
- F He
- F Massa
- F Montecucco
- F Montecucco
- F Willecke
- G Griffin
- G Murineddu
- GD Duerr
- GJ Maestroni
- GM Giblin
- GM Giblin
- H Gui
- H Gui
- H Iwamura
- H Wang
- I Matias
- J Bakali El
- J Bakali El
- J Gertsch
- J Joseph
- J Malysz
- J Sardinha
- J Suarez
- J Suarez
- J Tang
- J Wen
- JC Ashton
- JD Leggett
- JF Cheer
- JG Zarruk
- JH Baek
- JJ McDougall
- JP Buchweitz
- JP Gong
- JS Walczak
- JT Castaneda
- JW Huffman
- K Coopman
- K Maresz
- K Maresz
- K Wright
- KJ Valenzano
- KL McCoy
- L Booker
- L Giannini
- L Hanus
- L Hanus
- L Walter
- LL Zhou
- M Agudelo
- M Alhouayek
- M Bari
- M Bayewitch
- M Bouaboula
- M Gokoh
- M Gokoh
- M Karsak
- M Patil
- M Rajesh
- M Rinaldi-Carmona
- M Yuan
- MA Engel
- MA Jorda
- MA Storr
- MA Storr
- Marie-Renée Blanchet
- MG Signorello
- MH Rhee
- Michel Laviolette
- MM Ibrahim
- MR El-Talatini
- MT Cencioni
- MV Catani
- MX Hao
- N Battista
- N Malek
- N Rayman
- N Rayman
- NE Buckley
- Nicolas Flamand
- O Ofek
- O Ofek
- P Carayon
- P Grimaldi
- PF Sumariwalla
- PS Amenta
- PS Amenta
- PS Naidu
- Q Lu
- QR Liu
- R Kurihara
- R Meccariello
- R Mechoulam
- RA Ross
- RA Ross
- RB Rock
- RG Pertwee
- RG Pertwee
- RG Pertwee
- RH Robinson
- RJ McKallip
- RR Petrov
- RS Chapman
- S Adhikary
- S Adhikary
- S Batkai
- S Fukuda
- S Galiegue
- S Ghosh
- S Kishimoto
- S Kishimoto
- S Kishimoto
- S Kishimoto
- S Merighi
- S Munro
- S Murikinati
- S Oka
- S Oka
- S Oka
- S Ortega-Gutierrez
- S Pasquini
- S Steffens
- S Tambaro
- S Yamaori
- S Zoppi
- SB Hanauer
- SD McAllister
- SF Lee
- SH Ramirez
- SJ Carlisle
- SK Goparaju
- SM Brown
- T Bisogno
- T Michler
- T Tanikawa
- TA Sherwood
- TK Eisenstein
- TP Dinh
- V Chiurchiu
- V Chiurchiu
- V Gasperi
- V Reichenbach
- VL Hegde
- VM Showalter
- W Gonsiorek
- W Insull Jr
- WA Devane
- WL Mitchell
- WS Sheng
- Y Do
- Y Kobayashi
- Y Marchalant
- Y Persidsky
- Y Yiangou
- Y Zhao
- Y Zhao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study