Numerical Study of Velocity Statistics in Steady Counterflow Quantum Turbulence

We investigate the velocity statistics by calculating the Biot--Savart velocity induced by vortex filaments in steady counterflow turbulence investigated in a previous study [Phys. Rev. B {\bf 81}, 104511 (2010)]. The probability density function (PDF) obeys a Gaussian distribution in the low-velocity region and a power-law distribution $v^{-3}$ in the high-velocity region. This transition between the two distributions occur at the velocity characterized by the mean inter-vortex distance. Counterflow turbulence causes anisotropy of the vortex tangle, which leads to a difference in the PDF for the velocities perpendicular to and parallel to the counterflow.Comment: 4 pages, 7 figure

Managing university records in the world of governance

Purpose: The purpose of the research reported here was to investigate the relationship between corporate governance and records management in the context of higher education in Sub-Saharan Africa Design/methodology/approach: This is qualitative research taking the form of a collective case study of six institutions Findings: That good records management can and does contribute to effective corporate governance and accountability. However, this relationship is not necessarily present in all circumstances Research limitations/implications: That further corporatisation in higher education is likely to be supported by, and result in, better records management Originality/value: The paper proposes governance record keeping as an approach to managing records and documents in the world of governance, audit and ris

Vortex density spectrum of quantum turbulence

The fluctuations of the vortex density in a turbulent quantum fluid are deduced from local second-sound attenuation measurements. These measurements are performed with a micromachined open-cavity resonator inserted across a flow of turbulent He-II near 1.6 K. The power spectrum of the measured vortex line density is compatible with a (-5/3) power law. The physical interpretation, still open, is discussed.Comment: Submitted to Europhys. Let

Interaction of the Host and Viral Genome and Their Influence on HIV Disease

The course of Human Immunodeficiency Virus type 1 (HIV) infection is a dynamic interplay in which both host and viral genetic variation, among other factors, influence disease susceptibility and rate of progression. HIV set-point viral load (spVL), a key indicator of HIV disease progression, has an estimated 30% of variance attributable to common heritable effects and roughly 70% attributable to environmental factors and/or additional non-genetic factors. Genome-wide genotyping and sequencing studies have allowed for large-scale association testing studying host and viral genetic variants associated with infection and disease progression. Host genomics of HIV infection has been studied predominantly in Caucasian populations consistently identifying human leukocyte antigen (HLA) genes and C-C motif chemokine receptor 5 as key factors of HIV susceptibility and progression. However, these studies don’t fully assess all classes of genetic variation (e.g., very rare polymorphisms, copy number variants etc.) and do not inform on non-European ancestry groups. Additionally, viral sequence variability has been demonstrated to influence disease progression independently of host genetic variation. Viral sequence variation can be attributed to the rapid evolution of the virus within the host due to the selective pressure of the host immune response. As the host immune system responds to the virus, e.g., through recognition of HIV antigens, the virus is able to mitigate this response by evolving HLA-specific escape mutations. Diversity of viral genotypes has also been correlated with moderate to strong effects on CD4+ T cell decline and some studies showing weak to no correlation with spVL. There is evidence to support these viral genetic factors being heritable between individuals and the evolution of these factors having important consequences in the genetic epidemiology of HIV infection on a population level. This review will discuss the host-pathogen interaction of HIV infection, explore the importance of host and viral genetics for a better understanding of pathogenesis and identify opportunities for additional genetic studies

Rapid turnover of T cells in acute infectious mononucleosis.

During acute infectious mononucleosis (AIM), large clones of Epstein-Barr virus-specific T lymphocytes are produced. To investigate the dynamics of clonal expansion, we measured cell proliferation during AIM using deuterated glucose to label DNA of dividing cells in vivo, analyzing cells according to CD4, CD8 and CD45 phenotype. The proportion of labeled CD8(+)CD45R0(+) T lymphocytes was dramatically increased in AIM subjects compared to controls (mean 17.5 versus 2.8%/day; p<0.005), indicating very rapid proliferation. Labeling was also increased in CD4(+)CD45R0(+) cells (7.1 versus 2.1%/day; p<0.01), but less so in CD45RA(+) cells. Mathematical modeling, accounting for death of labeled cells and changing pool sizes, gave estimated proliferation rates in CD8(+)CD45R0(+) cells of 11-130% of cells proliferating per day (mean 47%/day), equivalent to a doubling time of 1.5 days and an appearance rate in blood of about 5 x 10(9) cells/day (versus 7 x 10(7) cells/day in controls). Very rapid death rates were also observed amongst labeled cells (range 28-124, mean 57%/day),indicating very short survival times in the circulation. Thus, we have shown direct evidence for massive proliferation of CD8(+)CD45R0(+) T lymphocytes in AIM and demonstrated that rapid cell division continues concurrently with greatly accelerated rates of cell disappearance

Kolmogorov spectrum of superfluid turbulence: numerical analysis of the Gross-Pitaevskii equation with the small scale dissipation

The energy spectrum of superfluid turbulence is studied numerically by solving the Gross-Pitaevskii equation. We introduce the dissipation term which works only in the scale smaller than the healing length, to remove short wavelength excitations which may hinder the cascade process of quantized vortices in the inertial range. The obtained energy spectrum is consistent with the Kolmogorov law.Comment: 4 pages, 4 figures and 1 table. Submitted to American Journal of Physic

Spectrum of turbulent Kelvin-waves cascade in superfluid helium

To explain the observed decay of superfluid turbulence at very low temperature, it has been proposed that a cascade of Kelvin waves (analogous to the classical Kolmogorov cascade) transfers kinetic energy to length scales which are small enough that sound can be radiated away. We report results of numerical simulations of the interaction of quantized vortex filaments. We observe the development of the Kelvin-waves cascade, and compute the statistics of the curvature, the amplitude spectrum (which we compare with competing theories) and the fractal dimension.Comment: 32 pages, 22 figure

InP integrated optical frequency comb generator using an amplified recirculating loop

A novel realisation of photonically integrated optical frequency comb generation is demonstrated on indium phosphide (InP) using a generic foundry platform. The architecture, based on the amplified recirculating loop technique, consists of cascaded electro-optic phase modulators embedded within a short waveguide loop. While an injected continuous wave laser signal is recirculated by the loop, the modulators are driven with a modulation frequency corresponding to the round-trip loop length frequency. This results in many phase coherent, evenly spaced optical comb lines being generated. The choice of InP as an integration platform allows immediate optical amplification of the modulated signal by embedded semiconductor optical amplifiers, enabling loop losses to be compensated and expanding the comb across broad optical bandwidths. This approach reduces the requirement for external, high-power optical amplifiers, improving the compactness and power efficiency of the full system. The system was modelled to identify off-resonance behaviour, outlining limits in matching both the modulation frequency and seed laser frequency to the round-trip loop frequency for optimal comb line generation to be achieved. The experimental device occupied a fraction of the 6 x 2 mm2 InP chip and operated at round-trip loop frequencies of 6.71 GHz to produce 59 comb lines within a 20 dB power envelope. All comb lines exhibited strong phase coherence as characterised by low composite phase noise measurements of -105 dBc/Hz at 100 kHz. A second device is also presented with a shorter loop length operating at ~10 GHz which generated 57 comb lines. Both loop configurations included short waveguide phase shifters providing a degree of tunability of the free spectral range with a tuning range of 150 MHz for small injection currents of less than 2.5 mA.This research work has been supported by the UK Engineering and Physical Sciences Research Council (EPSRC) through the Integrated Photonics and Electronic Systems (IPES) Centre of Doctoral Training and PICSat project (EPSRC Reference: EP/S000976/1)

Thermal dissipation in quantum turbulence

The microscopic mechanism of thermal dissipation in quantum turbulence has been numerically studied by solving the coupled system involving the Gross-Pitaevskii equation and the Bogoliubov-de Gennes equation. At low temperatures, the obtained dissipation does not work at scales greater than the vortex core size. However, as the temperature increases, dissipation works at large scales and it affects the vortex dynamics. We successfully obtained the mutual friction coefficients of the vortex dynamics as functions of temperature, which can be applied to the vortex dynamics in dilute Bose-Einstein condensates.Comment: 4 pages, 6 figures, submitted to AP