Ferrocenylnaphthalene Diimide-Based Electrochemical Detection of Aberrant Methylation in hTERT Gene

Since aberrant methylation at CpG sites is linked to the silencing of tumor suppressor genes, DNA methylation analysis is important for cancer diagnosis. We developed ferrocenylnaphthalene diimide (FND), which has two ferrocenyl moieties at the substituent termini, as an electrochemical indicator for hybridized DNA duplexes. In this study, we attempted to detect aberrant methylation of human telomerase reverse transcriptase gene (hTERT), an efficient cancer marker, using FND-based hybridization coupled with electrochemical detection via a multi-electrode chip

(GaAl)As可視半導体レーザの信頼性とモード制御

京都大学0048新制・論文博士工学博士乙第5381号論工博第1739号新制||工||614(附属図書館)UT51-59-K207(主査)教授 松波 弘之, 教授 川端 昭, 教授 佐々木 昭夫学位規則第5条第2項該当Kyoto UniversityDFA