15 research outputs found

    PPARγ遺伝子多型は健常男性におけるインスリン抵抗性の運動による変化に関係している

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    取得学位 : 博士(医学), 学位授与番号 : 医博乙第1592号, 学位授与年月日 : 平成16年7月7日, 学位授与大学 : 金沢大

    The transient appearance of anti-GAD antibody in a type 2 diabetic patient with empyema

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    金沢大学医薬保健研究域医学

    Transient anti-GAD antibody positivity and acute pancreatitis with pancreas tail swelling in a patient with susceptible haplotype for type 1 diabetes mellitus

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    金沢大学医薬保健研究域医学系A 57-year-old man was admitted to our hospital complaining of poor appetite. He had been diagnosed with diabetes mellitus and was anti-GAD antibody (GAD-Ab) negative 1 year previously, at the age of 56 years old. Abdominal CT revealed pancreas tail swelling; elastase-I level was elevated and he was diagnosed with pancreatitis. The level of GAD-Ab was increased and HLA haplotype was DRB1*0901-DQB1*0303, which is seen frequently in type 1 diabetic Japanese patients. However, his endogenous insulin secretion ability was not deteriorated. After elastase-I level and pancreas swelling improved, GAD-Ab returned to a normal range. One year after the onset of pancreas swelling, he was still not in an insulin-dependent state. In this case, transient GAD-Ab positivity with susceptible haplotype for type 1 diabetes mellitus might have been induced by a GAD antigen discharged from the destroyed islet due to pancreatitis. © 2009 The Japanese Society of Internal Medicine
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