ダッチアイリスの休眠を調節する要因に関する研究, 特にホルモン的観点より

京都大学0048新制・論文博士農学博士乙第2809号論農博第585号新制||農||201(附属図書館)学位論文||S50||N783(農学部図書室)4626UT51-50-J372(主査)教授 塚本 洋太郎, 教授 深海 浩, 教授 瀧本 敦学位規則第5条第2項該当Kyoto UniversityDA

Generalized weighted Hardy's inequalities with compact perturbations

In the present paper we shall study a variational problem relating the weighted Hardy inequalities with sharp missing terms. As weights we treat non-doubling functions of the distance to the boundary of bounded domain.Comment: arXiv admin note: text overlap with arXiv:2008.05167, arXiv:2012.0876

On the critical Caffarelli-Kohn-Nirenberg type inequalities involving super-logarithms

We establish the Caffarelli-Kohn-Nirenberg type inequalities involving{ super-logarithms (infinitely iterated logarithms).} As a result the critical Caffarelli-Kohn-Nirenberg type inequalities will be improved, and in certain cases the best constants will be discovered

High-speed atomic force microscopy for observing protein molecules in dynamic action

Directly observing protein molecules in dynamic action at high spatiotemporal resolution has long been a holy grail for biological science. To materialize this long quested dream, I have been developing high-speed atomic force microscopy (HS-AFM) since 1993. Tremendous strides were recently accomplished in its high-speed and low-invasive performances. Consequently, various dynamic molecular actions, including bipedal walking of myosin V and rotary propagation of structural changes in F1-ATPase, were successfully captured on video. The visualized dynamic images not only provided irrefutable evidence for speculated actions of the protein molecules but also brought new discoveries inaccessible with other approaches, thus giving great mechanistic insights into how the molecules function. HS-AFM is now transforming "static" structural biology into dynamic structural bioscience. © 2017 SPIE

Approximating the longest path length of a stochastic DAG by a normal distribution in linear time

AbstractThis paper presents a linear time algorithm for approximating, in the sense below, the longest path length of a given directed acyclic graph (DAG), where each edge length is given as a normally distributed random variable. Let F(x) be the distribution function of the longest path length of the DAG. Our algorithm computes the mean and the variance of a normal distribution whose distribution function F˜(x) satisfies F˜(x)⩽F(x) as long as F(x)⩾a, given a constant a (1/2⩽a<1). In other words, it computes an upper bound 1−F˜(x) on the tail probability 1−F(x), provided x⩾F−1(a). To evaluate the accuracy of the approximation of F(x) by F˜(x), we first conduct two experiments using a standard benchmark set ITC'99 of logical circuits, since a typical application of the algorithm is the delay analysis of logical circuits. We also perform a worst case analysis to derive an upper bound on the difference F˜−1(a)−F−1(a)

Video imaging of biomolecular processes by high-speed AFM

金沢大学理工研究域数物科学系The imaging rate of conventional atomic force microscopy (AFM) is too low to capture the dynamic behavior of biomolecules. To overcome this problem, we have been developing various devices and techniques, including small cantilevers and high-speed scanners. The feedback bandwidth in the tapping-mode now exceeds 100 kHz and hence the maximum possible imaging rate reaches 25 frames per sec (fps). Importantly the tip-force exerting onto the sample is dramatically reduced. Thus, it is now possible to take video images of dynamically moving protein molecules in action without disturbing their function, including walking myosin V molecules along actin tracks

High-speed atomic force microscopy coming of age

High-speed atomic force microscopy (HS-AFM) is now materialized. It allows direct visualization of dynamic structural changes and dynamic processes of functioning biological molecules in physiological solutions, at high spatiotemporal resolution. Dynamic molecular events unselectively appear in detail in an AFM movie, facilitating our understanding of how biological molecules operate to function. This review describes a historical overview of technical development towards HS-AFM, summarizes elementary devices and techniques used in the current HS-AFM, and then highlights recent imaging studies. Finally, future challenges of HS-AFM studies are briefly discussed. © 2012 IOP Publishing Ltd