Control of rat glomerular microcirculation by juxtaglomerular adenosine A1 receptors

Control of rat glomerular microcirculation by juxtaglomerular adenosine A1 receptors. The role of adenosine A1 receptors in the glomerular microcirculation and tubuloglomerular feedback (TGF) was studied in anesthetized Sprague-Dawley rats. TGF activity was assessed as the reduction in proximal tubular stop-flow pressure (SFP) on establishing orthograde perfusion of the loop of Henle with artificial tubular fluid at 40 nl/min. Administration of a selective A1 receptor antagonist, KW-3902 (0.5 μg/kg/min i.v.), increased fractional excretion of Na (FENa) 4.3-fold without changing blood pressure, glomerular filtration rate, renal plasma flow, or filtration fraction. SFP in the absence of distal flow (SFP0) increased, and TGF-mediated SFP reduction was suppressed dose dependently [by 23 ± 2% from an SFP0 of 34 ± 1mm Hg, by 15 ± 4% from 36 ± 2mm Hg, and by 2 ± 1% from 39 ± 1mm Hg during vehicle, low- and high-dose infusions (0.5 and 5.0 μg/kg/min), respectively]. Intratubular or peritubular capillary administration of 10-4m KW-3902 completely suppressed TGF without affecting SFP0. TGF suppression and elevation of SFP0 during systemic A1 blockade indicated vasodilation, both in the afferent arteriole and more proximal preglomerular vessels. Inhibition of tubular Na reabsorption combined with TGF suppression allowed the marked natriuresis. TGF suppression through systemic, luminal, and peritubular application of the drug suggest that juxtaglomerular apparatus A1 receptors are important in the control of glomerular microcirculation

(R)-1-phenylethylammonium N-tetradecanoyl-L-phenylalaninate monohydrate

金沢大学理工研究域物質化学系The title compound, C8H12N+·C 23H36,NO3-·H2O, has one molecule of N-tetradecanoyl-L-phenylalanine and one molecule of (R)-l-phenylethylamine as a diastereoisomeric salt, and a water molecule in the asymmetric unit. In the crystal structure, the packing of the molecules is stabilized by N - H⋯O and O-H⋯O hydrogen bonds involving the amide, ammonium and carboxylate groups, and the solvent water molecule. © 2006 International Union of Crystallography Printed in Great Britain - all rights reserved

The Second Survey of the Molecular Clouds in the Large Magellanic Cloud by NANTEN I: Catalog of Molecular Clouds

The second survey of the molecular clouds in 12CO (J = 1-0) was carried out in the Large Magellanic Cloud by NANTEN. The sensitivity of this survey is twice as high as that of the previous NANTEN survey, leading to a detection of molecular clouds with M_CO > 2 x 10^4 M_sun. We identified 272 molecular clouds, 230 of which are detected at three or more observed positions. We derived the physical properties, such as size, line width, virial mass, of the 164 GMCs which have an extent more than the beam size of NANTEN in both the major and minor axes. The CO luminosity and virial mass of the clouds show a good correlation of M_VIR propto L_CO^{1.1 +- 0.1} with a Spearman rank correlation of 0.8 suggesting that the clouds are in nearly virial equilibrium. Assuming the clouds are in virial equilibrium, we derived an X_CO-factor to be ~ 7 x 10^20 cm^-2 (K km s^-1)^-1. The mass spectrum of the clouds is fitted well by a power law of N_cloud(>M_CO) proportional to M_CO^{-0.75 +- 0.06} above the completeness limit of 5 x 10^4 M_sun. The slope of the mass spectrum becomes steeper if we fit only the massive clouds; e.g., N_cloud (>M_CO) is proportional to M_CO^{-1.2 +- 0.2} for M_CO > 3 x 10^5 M_sun.Comment: 54 pages in total, 18 figures (21 files) and 4 tables, to appear in Astrophysical Journal Supplement Series. A full color version with higher resolution figures is available at http://www.a.phys.nagoya-u.ac.jp/~kawamura/research/NANTEN_LMC_1_preprint_highres.pd