Arginine enriched EN after total gastrectomy

The effects of early enteral arginine-rich nutrition (EAN) were analyzed among patients undergoing curative-intent total gastrectomy for gastric cancer. There were 19 patients in this prospective study, all randomly assigned to either a parenteral nutrition (PN) group or an EAN group for the first seven days after surgery. The EAN group received 1.8-fold greater arginine (10.1 g / day) compared with the PN group, which was administered through an enteral tube inserted into the jejunal loop. Both groups were provided almost identical amounts of total amino acids (54 g / day), and the total energy was set at 65% of the total requirement (25 kcal / kg / day). No significant differences were observed between the two groups in postoperative complications, length of hospital stay, oral intake, nutritional status, or body weight. The serum arginine profile was similar in the two groups, as it decreased significantly on postoperative day (POD) 1, and gradually returned to preoperative levels by POD 7. The nitrogen balance remained negative until POD 7 in the PN group, but turned neutral at POD 7 in the EAN group. While we could not confirm body weight loss improvement, these results suggested that early arginine-rich enteral nutrition could improve the nitrogen balance after total gastrectomy

iPSC-derived type IV collagen α5-expressing kidney organoids model Alport syndrome

ヒトiPS細胞から作製した腎オルガノイドを用いたアルポート症候群病態モデルの開発. 京都大学プレスリリース. 2023-09-28.iPSC-derived kidney organoids to model a lifelong renal disease. 京都大学プレスリリース. 2023-10/17.Alport syndrome (AS) is a hereditary glomerulonephritis caused by COL4A3, COL4A4 or COL4A5 gene mutations and characterized by abnormalities of glomerular basement membranes (GBMs). Due to a lack of curative treatments, the condition proceeds to end-stage renal disease even in adolescents. Hampering drug discovery is the absence of effective in vitro methods for testing the restoration of normal GBMs. Here, we aimed to develop kidney organoid models from AS patient iPSCs for this purpose. We established iPSC-derived collagen α5(IV)-expressing kidney organoids and confirmed that kidney organoids from COL4A5 mutation-corrected iPSCs restore collagen α5(IV) protein expression. Importantly, our model recapitulates the differences in collagen composition between iPSC-derived kidney organoids from mild and severe AS cases. Furthermore, we demonstrate that a chemical chaperone, 4-phenyl butyric acid, has the potential to correct GBM abnormalities in kidney organoids showing mild AS phenotypes. This iPSC-derived kidney organoid model will contribute to drug discovery for AS

ナンキョク ショウワキチ ムデントウ ガイヘキ パネル ノ マゲ キョウド シケン

1957年に昭和基地に建設され、40年経過した木質プレハブ建物一式を日本に持ち帰り、各種の耐久性試験を行った。壁パネルについての剛性、強度を実験的に調査した結果、次のようなことがわかった。(1) 設計荷重範囲でのパネルの挙動は弾性的であり、構造部材としての設計要求性能がまだ保持されている。(2) パネルの面外曲げ剛性、曲げ強度ともにわずかではあるが劣化が認められる。パネル構成材のうち、檜の芯材、枠材は直接外気に接することが少ないために保存状態が良く、ほとんど材料性能の劣化は見られなかった。合板も水に冒されない限り性能に大きな変化はない。しかし外装ペイントの保護層だけでは合板接着層の劣化は完全に押さえられず、経年による性能低下は建物外部の合板から徐々に進行していると推測できる。1982年に行われた同形式の壁パネル試験結果と比較したパネル剛性のわずかな変化は、この表面合板の性能劣化が原因と考えられる。Durability tests of the old wireless hut were performed in 1997. The prefabricated wooden hut had been built at Syowa Station in 40 years ago. It was dismantled and brought back to Japan for many kinds of durability test. The results of the durability test on the mechanical behavior of wooden wall panels used in the old wireless hut are as follows: (1) Required performance in the mechanical property of the wall panel at the original design is retained sufficiently at present. (2) Among the structural properties of the wooden panel, bending stiffness and bending strength were weakened gradually by decay of plywood exposed to the outside. The inner component parts of the wall panel preserved by the surface plywood boards have retained their initial high performance until now. The wooden panel surface coating technique will be very important to prevent weakening of structural performance

Bending strength tests of a wooden wall panel used in the wireless hut built in 1957 at Syowa Station, Antarctica

Durability tests of the old wireless hut were performed in 1997. The prefabricated wooden hut had been built at Syowa Station in 40 years ago. It was dismantled and brought back to Japan for many kinds of durability test. The results of the durability test on the mechanical behavior of wooden wall panels used in the old wireless hut are as follows: (1) Required performance in the mechanical property of the wall panel at the original design is retained sufficiently at present. (2) Among the structural properties of the wooden panel, bending stiffness and bending strength were weakened gradually by decay of plywood exposed to the outside. The inner component parts of the wall panel preserved by the surface plywood boards have retained their initial high performance until now. The wooden panel surface coating technique will be very important to prevent weakening of structural performance