コンメン ヒフクジュツ ニツイテ

Localized gingival recession and root exposure may cause an esthetic problem, root dentin hypersensitivity, root caries, and difficulties in plaque control. To solve the problems, root coverage procedures have been developed since 1950s. These surgical procedures are classified as pedicle soft tissue graft procedures, free soft tissue graft procedures, and regenerative procedures. Pedicle soft tissue graft procedures include the laterally repositioned flap procedure, the double papilla flap, the oblique rotational flap, the coronally advanced flap procedure, and a semi-lunar coronally repositioned flap procedure. Free soft tissue graft procedures contain the free gingival graft and the connective tissue graft. Regenerative procedures are the modifications of coronally advanced flap utilizing barrier membranes or enamel matrix derivatives. Histological observations of the human root surface treated with soft tissue graft showed that new connective tissue attachment was formed in some areas, and epithelial attachment was found in other areas. Based on the literatures, the connective tissue graft results in superior root coverage comparing with other procedures. Similarly, complete root coverage was expected in highest predictability in the connective tissue graft, especially in class I or II recession defects. The color match of the grafted area to the adjacent gingiva is esthetically more favorable with the connective tissue graft than that of a free gingival graft. However, only partial coverage may be expected in class III or IV recession defects

Psychometric properties of the J apanese version of the S ocial P hobia I nventory

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/97457/1/pcn12037.pd

ハワイ州における高大連携プログラム <ノート>

米国では、現在、初等教育から高等教育までのシームレスな接続をめざす「P-16（またはK-16, P-20）」と呼ばれる教育政策が多くの州において展開されている。広島県の公立高校と姉妹校締結を行っているハワイ州の高校における高大接続に関する調査の際に、P-20（ハワイ州）プログラムについて調査を行う機会を得た。米国全体における最近の状況とハワイ州における状況についてその特徴を分析し、我が国における高大連携及び高大接続への示唆を検討したい。本研究はJSPS科研費 23653268 の助成を受けたものである

AO入試の何が変わり，何が変わらなかったか : 広島大学AO入試の10年 <ノート>

広島大学でAO入試を開始して10年、この間、導入当初の制度設計から変更した点もあれば、現在に至るまで変わらない点もある。大学入試センター試験を課す入試方式（AO入試Ⅱ型）への移行や入試期間の短縮等当初から変更した点は、より適切な入試制度として変更が求められたものであり、入試時期等当初からずっと変わらなかった点は、本学のAO入試制度として適切であったものと言える。このような観点からの入試制度の検証と入学者の学業成績の追跡調査等から、現時点での本学のAO入試の成果と課題をまとめる

Relationship of IE and oral conditions

Objectives Infective endocarditis (IE) is a life-threatening infectious disease, but the pathogenesis of the disease remains uncertain. The objective of this study was to examine whether oral infectious conditions are associated with the occurrence of IE in valvular heart disease (VHD) patients. Materials and Methods A total of 119 periodontitis (P) patients with or without VHD were enrolled, and cross-sectional analyses were performed. Patients were classified as follows: 1) mild-to-moderate P without VHD, 2) mild-to-moderate P with VHD, 3) severe P without VHD, or 4) severe P with VHD. A total of 78 VHD patients were classified as 1) VHD without IE or 2) VHD with IE. Conditional logistic regression analysis was performed to compute the odds ratio (OR) and 95% confidence interval (CI). Results No significant differences were observed between patients with or without VHD in oral conditions. A significant increase in the percentage of alveolar bone loss in VHD patients with IE was observed compared with that of patients without IE. The ratio of both Porphyromonas gingivalis (Pg) IgG titer>1.68 and Pg fimA type II genotype in patients with IE was significantly higher than in patients without IE. There was a significant correlation between the occurrence of IE and clinical oral findings (number of remaining teeth: OR, 0.17; rate of alveolar bone loss>40%: OR, 11.8). Conclusions VHD patients with IE might have severe periodontitis compared with patients without IE, although further investigation will be needed because this is based on only 7 VHD patients with IE. Clinical relevance The patients with IE had fewer remaining teeth, more advanced bone resorption compared with those of patients without IE. These findings suggest a possible association between the occurrence of IE and periodontal infection

Variable Stars in the Magellanic Clouds: Results from OGLE and SIRIUS

We have performed a cross-identification between OGLE-II data and single-epoch SIRIUS JHK survey data in the LMC and SMC. After eliminating obvious spurious variables, we determined the pulsation periods for 9,681 and 2,927 variables in the LMC and SMC, respectively. Based on these homogeneous data, we studied the pulsation properties and metallicity effects on period-K magnitude (PK) relations by comparing the variable stars in the LMC and SMC. The sample analyzed here is much larger, and we found the following new features: (1) variable red giants in the SMC form parallel sequences on the PK plane, just like those found by Wood (2000) in the LMC; (2) both of the sequences A and B of Wood (2000) have discontinuities, and they occur at the K-band luminosity of the TRGB; (3) the sequence B of Wood (2000) separates into three independent sequences B+- and C'; (4) comparison between the theoretical pulsation models (Wood et al. 1996) and observational data suggests that the variable red giants on sequences C and newly discovered C' are pulsating in the fundamental and first overtone mode, respectively; (5) the theory can not explain the pulsation mode of sequences A+- and B+-, and they are unlikely to be the sequences for the first and second overtone pulsators, as was previously suggested; (6) the zero points of PK relations of Cepheids in the metal deficient SMC are fainter than those of LMC ones by ~0.1 mag but those of SMC Miras are brighter than those of LMC ones by ~0.13 mag, which are probably due to metallicity effects.Comment: 9 pages, 10 figures, accepted for publication in MNRAS. High resolution version is available at: http://www.ioa.s.u-tokyo.ac.jp/~yita/scr/astro/papers/RefereedPaper/yitaMD250 .pd

Using the mood disorder questionnaire and bipolar spectrum diagnostic scale to detect bipolar disorder and borderline personality disorder among eating disorder patients

Abstract Background Screening scales for bipolar disorder including the Mood Disorder Questionnaire (MDQ) and Bipolar Spectrum Diagnostic Scale (BSDS) have been plagued by high false positive rates confounded by presence of borderline personality disorder. This study examined the accuracy of these scales for detecting bipolar disorder among patients referred for eating disorders and explored the possibility of simultaneous assessment of co-morbid borderline personality disorder. Methods Participants were 78 consecutive female patients who were referred for evaluation of an eating disorder. All participants completed the mood and eating disorder sections of the SCID-I/P and the borderline personality disorder section of the SCID-II, in addition to the MDQ and BSDS. Predictive validity of the MDQ and BSDS was evaluated by Receiver Operating Characteristic analysis of the Area Under the Curve (AUC). Results Fifteen (19%) and twelve (15%) patients fulfilled criteria for bipolar II disorder and borderline personality disorder, respectively. The AUCs for bipolar II disorder were 0.78 (MDQ) and 0.78 (BDSD), and the AUCs for borderline personality disorder were 0.75 (MDQ) and 0.79 (BSDS). Conclusions Among patients being evaluated for eating disorders, the MDQ and BSDS show promise as screening questionnaires for both bipolar disorder and borderline personality disorder.http://deepblue.lib.umich.edu/bitstream/2027.42/112636/1/12888_2012_Article_1235.pd

Using the mood disorder questionnaire and bipolar spectrum diagnostic scale to detect bipolar disorder and borderline personality disorder among eating disorder patients

BACKGROUND: Screening scales for bipolar disorder including the Mood Disorder Questionnaire (MDQ) and Bipolar Spectrum Diagnostic Scale (BSDS) have been plagued by high false positive rates confounded by presence of borderline personality disorder. This study examined the accuracy of these scales for detecting bipolar disorder among patients referred for eating disorders and explored the possibility of simultaneous assessment of co-morbid borderline personality disorder. METHODS: Participants were 78 consecutive female patients who were referred for evaluation of an eating disorder. All participants completed the mood and eating disorder sections of the SCID-I/P and the borderline personality disorder section of the SCID-II, in addition to the MDQ and BSDS. Predictive validity of the MDQ and BSDS was evaluated by Receiver Operating Characteristic analysis of the Area Under the Curve (AUC). RESULTS: Fifteen (19%) and twelve (15%) patients fulfilled criteria for bipolar II disorder and borderline personality disorder, respectively. The AUCs for bipolar II disorder were 0.78 (MDQ) and 0.78 (BDSD), and the AUCs for borderline personality disorder were 0.75 (MDQ) and 0.79 (BSDS). CONCLUSIONS: Among patients being evaluated for eating disorders, the MDQ and BSDS show promise as screening questionnaires for both bipolar disorder and borderline personality disorder

Numerical study of air-entraining and submerged vortices in a pump sump

Numerical detection of harmful vortices in pump sumps, such as an air-entraining vortex (AEV) and a submerged vortex (SMV), is crucially important to develop the drain pump machinery. We performed numerical simulations of the benchmark experiments of the pump sump conducted by Matsui et al. (2006 and 2016) using the OpenFOAM and compared the simulation results with the experimental data considering the effects of turbulence model, grid density and detection method of the vortices. We studied the threshold of the gas-liquid volume fraction of the VOF method and the second invariant of velocity gradient tensor to identify AEV and SMV. The methods proposed in the present paper were found to be very effective for the detection of the vortices, and the simulation results by RANS with the SST k-omega model successfully reproduced the experimental data. LES with the Smagorinsky model, however, was sensitive to the grid system and difficult to reproduce the experimental data even for the finest grid system having 3.7 million cells in the present study

High Glucose Induces Severe Periodontitis.

Background/Aims: Diabetic patients are susceptible to severe periodontitis, but the precise mechanism is not fully understood. Aim of this study was to explore the biological pathogenesis of severe periodontitis in diabetic patients focusing on the crosstalk of human gingival fibroblasts (HGFs) and macrophages. Methods: A total of 70 periodontitis patients with or without diabetes mellitus (DM) were enrolled, and the statistical relationships of diabetic conditions to the periodontal inflammatory parameters were examined by cross-sectional study. In in vitro study, HGFs cell line CRL-2014® (ATCC) and differentiated THP-1 macrophages were cultured with normal glucose (NG: 5.5 mM) or high glucose (HG: 25 mM) condition, and treated with indicated inflammatory factors such as calprotectin (CPT), interleukin (IL)-1β and IL-6. To examine the effects of HG on soluble IL-6 receptor (sIL-6R) production in THP-1 macrophages, the supernatants were collected and the sIL-6R levels were measured by ELISA. To examine the effects of HG on IL-1β or IL-6-induced matrix metalloproteinase (MMPs) production in HGFs, the supernatants were collected. Levels of MMP-1 and tissue inhibitor of MMP-1 (TIMP-1) were measured by ELISA. Finally, after conditioned medium (CM) from THP-1 macrophages cultured with NG or HG conditions was collected, HGFs were treated with the CM. The supernatants were collected 24 hours later and the levels of MMP-1 and TIMP-1 were measured. To examine the specific effects of IL-1β contained in CM on MMP-1 and TIMP-1 production in HGFs, IL-1 receptor antagonist (IL-1ra) was used. Results: There were statistical correlation between IL-1β and sIL-6R levels in gingival crevicular fluid (GCF) and HbA1c in periodontitis patients with DM (IL-1β: P=0.035, sIL-6R: P=0.040). HG and CPT significantly induced sIL-6R production in THP-1 macrophages. HG significantly enhanced IL-1β or IL-6/sIL-6R-induced MMP-1 production in HGFs. The increase of MMP-1 by both IL-1β and IL-6/sIL-6R was significantly inhibited by specific ERK or IκB inhibitors. Corresponding to the regulation of MMP-1 production, HG condition increased the phosphorylation of p44/42 MAPK and IκBα in HGFs treated with IL-1β or IL-6/sIL-6R. Finally, MMP-1 production in HGFs cultured with HG increased significantly by CM from THP-1 macrophages cultured with HG. The induction of MMP-1 by the CM from THP-1 macrophages cultured with HG was significantly inhibited by dose dependent of IL-1ra in HGFs cultured with HG. Conclusion: Diabetic conditions such as HG induce IL-1β and sIL-6R production from macrophages in inflammatory periodontal tissues and may exacerbate the periodontitis synergistically via MMP-1 production from HGFs