65 research outputs found
Squashed Kerr-Godel Black Holes - Kaluza-Klein Black Holes with Rotations of Black Hole and Universe -
Applying squashing transformation to Kerr-Godel black hole solutions, we
present a new type of a rotating Kaluza-Klein black hole solution to the
five-dimensional Einstein-Maxwell theory with a Chern-Simon term. The new
solutions generated via the squashing transformation have no closed timelike
curve everywhere outside the black hole horizons. At the infinity, the metric
asymptotically approaches a twisted S^1 bundle over a four-dimensional
Minkowski space-time. One of the remarkable features is that the solution has
two independent rotation parameters along an extra dimension associated with
the black hole's rotation and the Godel's rotation. The space-time also admits
the existence of two disconnected ergoregions, an inner ergoregion and an outer
ergoregion. These two ergoregions can rotate in the opposite direction as well
as in the same direction.Comment: 24 pages, 16 figure
Rotating Kaluza-Klein Multi-Black Holes with Godel Parameter
We obtain new five-dimensional supersymmetric rotating multi-Kaluza-Klein
black hole solutions with the Godel parameter in the Einstein-Maxwell system
with a Chern-Simons term. These solutions have no closed timelike curve outside
the black hole horizons. At the infinity, the space-time is effectively
four-dimensional. Each horizon admits various lens space topologies
L(n;1)=S^3/Z_n in addition to a round S^3. The space-time can have outer
ergoregions disjointed from the black hole horizons, as well as inner
ergoregions attached to each horizon. We discuss the rich structures of
ergoregions.Comment: 19 pages, 4 figure
Charged Rotating Kaluza-Klein Black Holes in Five Dimensions
We construct a new charged rotating Kaluza-Klein black hole solution in the
five-dimensional Einstein-Maxwell theory with a Chern-Simon term. The features
of the solutions are also investigated. The spacetime is asymptotically locally
flat, i.e., it asymptotes to a twisted bundle over the
four-dimensional Minkowski spacetime. The solution describe a non-BPS black
hole rotating in the direction of the extra dimension. The solutions have the
limits to the supersymmetric black hole solutions, a new extreme non-BPS black
hole solutions and a new rotating non-BPS black hole solution with a constant
twisted fiber.Comment: 18 pages, 4 figure
Postural stability during one-leg stance on an unstable moving platform and its relationship with each leg
This study examined the laterality of the supporting leg in postural stability during a one-leg stance test on an unstable moving platform and its practice effect. 30 male university students were evaluated using the omnidirection stability index (OSI) during a one-leg stance test on an unstable moving platform (three trials). The leg used when kicking a ball was defined as the manipulation leg (ML) and the supporting leg was defined as the non-manipulation leg (NML). According to the two-way repeated measures analysis of variance (ANOVA; trials × legs), a statistically significant difference was observed only on the leg factor, and OSI values of the second and third trials were less for the ML than the NML. The correlation between both legs was statistically significant but not high. The ML was superior to NML with regard to stability, and no practice effect with trials was evident in either leg. © Perceptual & Motor Skills 2013
Association Between SLFN11 and Antitumor Activity of Trabectedin
Background/Aim: Trabectedin is a DNA-damaging agent and has been approved for the treatment of patients with advanced soft tissue sarcoma. Schlafen 11 (SLFN11) was identified as a dominant determinant of the response to DNA-damaging agents. The aim of the study was to clarify the association between SLFN11 expression and the antitumor activity of trabectedin. Materials and Methods: The antitumor activity of trabectedin was evaluated under different expression levels of SLFN11 regulated by RNA interference and CRISPR-Cas9 systems, and the combined antitumor activity of ataxia telangiectasia and Rad3-related protein kinase (ATR) inhibitor and trabectedin in sarcoma cell lines using in vitro a cell viability assay and in vivo xenograft models. Results: SLFN11-knockdown cell lines had a lower sensitivity to trabectedin, compared to parental cells. ATR inhibitor enhanced the antitumor activity of trabectedin in SLFN11-knockdown cells and in a SLFN11-knockout xenograft model. Conclusion: SLFN11 expression might be a key factor in the antitumor activity of trabectedin
Interference effects in high-order harmonics from colloidal perovskite nanocrystals excited by an elliptically polarized laser
Halide perovskite nanocrystals are suitable materials for photonic devices because their highly efficient luminescence can be tuned over a wide wavelength range by changing the nanocrystal composition and size. Here, we report on the high-order harmonic generation in a solution-processed perovskite CsPbBr₃ nanocrystal film that is excited by a strong midinfrared laser. We observe harmonics up to the 13th order, which is ultraviolet light well above the band-gap energy. By using elliptically polarized laser light, we analyze the influence of the sample structure on the intensity of the 5th harmonic. It is also found that the randomness in the orientation of the nanocrystals in the film induces a reduction in the harmonic intensities due to the interference among the harmonics emitted from nanocrystals with different phases. Our observation of high-order harmonics from nanocrystal films opens a way towards the development of an intensity modulator that can be tuned simply by changing the excitation ellipticity
Syntheses of (±)-clavicipitic acid and its derivatives
金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学
The Impact of KRAS Mutation in Patients With Sporadic Nonampullary Duodenal Epithelial Tumors
INTRODUCTION: The genomic characterization of primary nonampullary duodenal adenocarcinoma indicates a genetic resemblance to gastric and colorectal cancers. However, a correlation between the clinical and molecular characteristics of these cancers has not been established. This study aimed to elucidate the clinicopathological features of sporadic nonampullary duodenal epithelial tumors, including their molecular characteristics and prognostic factors.
METHODS: One hundred forty-eight patients with sporadic nonampullary duodenal epithelial tumors were examined in this study. Patient sex, age, TNM stage, tumor location, treatment methods, histology, KRAS mutation, BRAF mutation, Fusobacterium nucleatum, mucin phenotype, and programmed death-ligand 1 (PD-L1) status were evaluated. KRAS and BRAF mutations, Fusobacterium nucleatum, mucin phenotype, and PD-L1 status were analyzed by direct sequencing, quantitative polymerase chain reaction, and immunochemical staining.
RESULTS: The median follow-up duration was 119.4 months. There were no deaths from duodenal adenoma (the primary disease). Kaplan-Meier analysis for duodenal adenocarcinoma showed a significant effect of TNM stage (P
DISCUSSION: Only KRAS mutation was a significant prognostic factor in primary sporadic nonampullary duodenal adenocarcinoma in cases in which TNM stage was considered
非小細胞肺がんと非小細胞肺がんから発生した転移性脳腫瘍における光線力学的測定によりPEPT1の発現は5-ALAから代謝されるプロトポルフィリンⅨの蓄積において正の相関をする
BACKGROUND: Recently, 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX fluorescence was reported to be a useful tool during total surgical resection of high-grade gliomas. However, the labeling efficacy of protoporphyrin IX fluorescence is lower in metastatic brain tumors compared to that in high-grade gliomas, and the mechanism underlying protoporphyrin IX fluorescence in metastatic brain tumors remains unclear. Lung cancer, particularly non-small cell lung cancer (NSCLC), is the most common origin for metastatic brain tumor. Therefore, we investigated the mechanism of protoporphyrin IX fluorescence in NSCLC and associated metastatic brain tumors. METHODS: Western blotting and quantitative real-time polymerase chain reaction (qRT-PCR) was employed to evaluate the protein and mRNA levels of five transporters and enzymes involved in the porphyrin biosynthesis pathway: peptide transporter 1 (PEPT1), hydroxymethylbilane synthase (HMBS), ferrochelatase (FECH), ATP-binding cassette 2 (ABCG2), and heme oxygenase 1 (HO-1). The correlation between protein, mRNA, and protoporphyrin IX levels in NSCLC cells were evaluated in vitro. Immunohistochemistry was used to determine proteins that played a key role in intraoperative protoporphyrin IX fluorescence in clinical samples from patients with NSCLC and pathologically confirmed metastatic brain tumors. RESULTS: A significant correlation between PEPT1 expression and protoporphyrin IX accumulation in vitro was identified by western blotting (P = 0.003) and qRT-PCR (P = 0.04). Immunohistochemistry results indicated that there was a significant difference in PEPT1 between the intraoperative protoporphyrin IX fluorescence-positive and protoporphyrin IX fluorescence-negative groups (P = 0.009). CONCLUSION: Expression of PEPT1 was found to be positively correlated with 5-ALA-induced protoporphyrin IX accumulation detected by photodynamic reaction in metastatic brain tumors originating from NSCLC.博士(医学)・甲第714号・令和元年年6月26日Copyright © 2019 Elsevier B.V. All rights reserved
- …