Des éléments de charronnerie gallo-romaine à Châteaumeillant (Cher)

International audienceThe excavation of the well no 269 in the Iron Age settlement of Châteaumeillant (Cher) exposed a considerable set of objects, dated from the end of the 2nd c. AD to the start of the 3rd c. AD, among which the iron objects are noteworthy. We identified some tools, building and household objects among others, but it is the high frequency of transport-related objects that gives a special feature to this set. We could thus identify some parts of a chariot’s internal structure: drive system, wheel parts, framework lining parts, etc. Their technical study and their comparison with other parts found elsewhere in the Empire territory, mainly in Neupotz (Germany), Italy or Roman provinces of Thrace and Pannonia, enabled us to submit a first approach of this type of vehicle. Their identification is highly interesting for the study of transport techniques during the Roman period, especially in Gaul where such a concentration remains unprecedented.La fouille du puits 269, sur l’habitat laténien de Châteaumeillant (Cher), a mis au jour un important ensemble de mobilier datable de la fin du IIe s. apr. J.-C. au début du IIIe s. apr. J.-C., parmi lequel le mobilier en fer est particulièrement remarquable. Outils, éléments de construction ou éléments de foyer sont quelques-uns des objets identifiés, mais c’est la concentration élevée de pièces en relation avec le transport qui donne un caractère particulier à cette série. Des éléments de la structure interne d’un char ont ainsi pu être identifiés : système de traction, éléments de roue, pièces de renfort de l’armature, etc. L’étude technique et les comparaisons avec d’autres pièces retrouvées ailleurs dans l’Empire, notamment à Neupotz (Allemagne), en Italie ou dans les provinces romaines de Thrace et de Pannonie, ont permis de proposer une première approche de ce type de véhicule. Leur identification présente un grand intérêt pour l’étude des techniques de transport à la période romaine, notamment en Gaule où une telle concentration reste inédite

Peptide platforms for metal ion sensing

Naturally occurring motifs have been redesigned to product fluorescent peptidyl-chemosensors that sensitively and selectively recognize Cu(II) or Fe(III). The modular nature of peptide architecture allows preparation and evaluation of potential sensors on solid supports

Creación de un nuevo recurso educativo virtual para estudiantes de grado en Farmacia

Depto. de Farmacia Galénica y Tecnología AlimentariaFac. de FarmaciaFALSEsubmitte

Nueva estrategia didáctica para fomentar la participación del alumnado en el proceso de aprendizaje en el ámbito de la tecnología farmacéutica (continuación)

Depto. de Farmacia Galénica y Tecnología AlimentariaFac. de FarmaciaFALSEsubmitte

Pulse Wave Velocity as Marker of Preclinical Arterial Disease: Reference Levels in a Uruguayan Population Considering Wave Detection Algorithms, Path Lengths, Aging, and Blood Pressure

Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (South American) population in order to characterize normal, reference, and threshold levels of PWV considering normal age-related changes in PWV and the prevailing blood pressure level during the study. A conservative approach was used, and we excluded symptomatic subjects; subjects with history of cardiovascular (CV) disease, diabetes mellitus or renal failure; subjects with traditional CV risk factors (other than age and gender); asymptomatic subjects with atherosclerotic plaques in carotid arteries; patients taking anti-hypertensives or lipid-lowering medications. The included subjects (n = 429) were categorized according to the age decade and the blood pressure levels (at study time). All subjects represented the “reference population”; the group of subjects with optimal/normal blood pressures levels at study time represented the “normal population.” Results. Normal and reference PWV levels were obtained. Differences in PWV levels and aging-associated changes were obtained. The obtained data could be used to define vascular aging and abnormal or disease-related arterial changes

Peptide platforms for metal ion sensing

Naturally occurring motifs have been redesigned to product fluorescent peptidyl-chemosensors that sensitively and selectively recognize Cu(II) or Fe(III). The modular nature of peptide architecture allows preparation and evaluation of potential sensors on solid supports

Integrated Evaluation of Age-Related Changes in Structural and Functional Vascular Parameters Used to Assess Arterial Aging, Subclinical Atherosclerosis, and Cardiovascular Risk in Uruguayan Adults: CUiiDARTE Project

This work was carried out in a Uruguayan (South American) population to characterize aging-associated physiological arterial changes. Parameters markers of subclinical atherosclerosis and that associate age-related changes were evaluated in healthy people. A conservative approach was used and people with nonphysiological and pathological conditions were excluded. Then, we excluded subjects with (a) cardiovascular (CV) symptoms, (b) CV disease, (c) diabetes mellitus or renal failure, and (d) traditional CV risk factors (other than age and gender). Subjects (n = 388) were submitted to non-invasive vascular studies (gold-standard techniques), to evaluate (1) common (CCA), internal, and external carotid plaque prevalence, (2) CCA intima-media thickness and diameter, (3) CCA stiffness (percentual pulsatility, compliance, distensibility, and stiffness index), (4) aortic stiffness (carotid-femoral pulse wave velocity), and (5) peripheral and central pressure wave-derived parameters. Age groups: ≤20, 21–30, 31–40, 41–50, 51–60, 61–70, and 71–80 years old. Age-related structural and functional vascular parameters profiles were obtained and analyzed considering data from other populations. The work has the strength of being the first, in Latin America, that uses an integrative approach to characterize vascular aging-related changes. Data could be used to define vascular aging and abnormal or disease-related changes

Fish mortality associated to volcanic eruptions in the Canary Islands

The Canary Islands are an active volcanic archipelago. In the last decade, volcanic activity has occurred twice on the youngest and western most islands: El Hierro (submarine eruption) in 2011-12, and La Palma (subaerial eruption) in 2021. 70 fish specimens of different species from El Hierro volcano and 14 from La Palma were necropsied. A notable high and early mortality of fishes was registered during the submarine eruption of El Hierro. In most of them, generalized congestion in the gills, liver, spleen, kidney, heart and rete mirabile of the swim bladder was observed. Some specimens also presented exophthalmia, gastric eversion, ocular haemorrhages, over-inflation of swim bladder and gas bubbles mainly on the skin and cornea. The eruption of La Palma volcano was characterized by the emission of large amounts of lava flows and pyroclastic deposits (mainly ash in size) both, on land and sea. Lava flowed on land and eventually reached the sea, forming lava deltas in the coastline of La Palma. This event was also associated with an increase in fish mortality in locations near to the lava deltas. Fishes presented ash particles in opercula/oral cavities and gills. In addition, several fishes presented an intense intestinal impaction composed of volcanic material including ashes and hyaloclastites fragments. To our best knowledge this study describes, for the first time, pathological findings in dead fishes associated with two different styles of recent volcanic eruptions in the Canary Islands

Pulse wave velocity as marker of preclinical arterial disease: reference levels in a uruguayan population considering wave detection algorithms, path lengths, aging, and blood pressure

Carotid-femoral pulse wave velocity (PWV) has emerged as the gold standard for non-invasive evaluation of aortic stiffness; absence of standardized methodologies of study and lack of normal and reference values have limited a wider clinical implementation. This work was carried out in a Uruguayan (South American) population in order to characterize normal, reference, and threshold levels of PWV considering normal age-related changes in PWV and the prevailing blood pressure level during the study. A conservative approach was used, and we excluded symptomatic subjects; subjects with history of cardiovascular (CV) disease, diabetes mellitus or renal failure; subjects with traditional CV risk factors (other than age and gender); asymptomatic subjects with atherosclerotic plaques in carotid arteries; patients taking anti-hypertensives or lipid-lowering medications. The included subjects (n = 429) were categorized according to the age decade and the blood pressure levels (at study time). All subjects represented the "reference population"; the group of subjects with optimal/normal blood pressures levels at study time represented the "normal population." Results. Normal and reference PWV levels were obtained. Differences in PWV levels and aging-associated changes were obtained. The obtained data could be used to define vascular aging and abnormal or disease-related arterial changes

Estudio comparativo de disgregación de diferentes formulaciones de olanzapina

Orally dispersable dosage forms are pharmaceutical products that disintegrate and dissolve rapidly in saliva when placed in the mouth. There are several types of formulations and manufacturing technologies, which may be used to produce orodispersibles. This work investigates different generic 10 mg olanzapine orodispersible products commercially available in Spain and the innovative Zyprexa Velotab manufactured by Eli Lilly & Co. Several aspects such as the shape and size, qualitative formulation, in vitro disintegration time in artificial saliva and packaging are analyzed. Among all the products tested Zyprexa Velotab showed an ultra fast disintegration in 3 seconds and the lowest dispersión.Las formas de dosificación bucodispersables son productos farmacéuticos que se disgregan y disuelven rápidamente en la saliva cuando se colocan en la boca. Hay distintos tipos de formulaciones y procesos de fabricación que pueden emplearse para su elaboración. En este trabajo, se estudia las diferencias entre los genéricos bucodispersables con 10 mg de olanzapina comercialmente disponibles en España y Zyprexa Velotab reconocido como innovación galénica. Se han analizado distintos aspectos, tales como forma y tamaño, formulación cualitativa, tiempo de disgregación in vitro en saliva artificial y material de acondicionamiento. Entre todos los productos analizados, Zyprexa Velotab fue el que tuvo una ultrarrápida disgregación en 3 segundos y el menor residuo de dispersión