About the Genesis of Pumice Deposits in the Region of Tarbagania and Pemzovaya Mountains in Kamchatka

В работе обсуждаются результаты изучения пемзовых отложений, расположенных в промежутке между вулканами Горелый и Мутновский на Камчатке. Приведены схема распространения пемзовых покровов и результаты петрохимических и геохимических исследований пемз и кислых лав. Выявлен ряд петрогеохимических особенностей пемз, указывающих на их вероятную генетическую обособленность.This paper discusses the results of study of pumice deposits between volcanoes Gorely and Mutnovskiy on Kamchatka. A scheme of the pumice sheets is presented. The results of petrochemical and geochemical studies of pumice and acidic lavas of Mutnovsky and Gorely are discussed. A number of petrogeochemical pumice features indicating their possible genetic isolation is revealed

Условия образования минеральных включений в гидротермальных метасоматитах г. Двугорбой, Южная Камчатка

Mineralogical and geochemical features of hydrothermal metasomatites of the Southern Kamchatka were studied. The probable physico-chemical conditions of formation of the studied mineral inclusions in hydrothermally altered rocks are considered.Исследования гидротермальных метасоматитов выявили их минералогические и геохимические особенности. Рассмотрены вероятные физико-химические условия образования исследованных минеральных включений в гидротермально измененных породах

The Conditions of Opal Formation within the NorthMutnovskaya Volcanic Zone of Kamchatka

Выявлены параметры образования вмещающих пород опаловой минерализации. Установлены тип метасоматоза измененных пород и его направленность. Выявлены минеральные включения в опалах, указывающие на металлоносность Мутновской гидротермальной системы. Рассмотрен вероятный механизм образования опалов Северо-Мутновской зоны, проведено сопоставление по ряду характеристик с опалами месторождения Радужное, Приморье.The characteristics of formation of the opal mineralization in the host rock within Mutnovskaya volcanic zone were studied. The type of metasomatic rock alteration and its consecutive order were established. The results of study allowed identifying the mineral inclusions in opals, which was linked to the metalliferousness of the Mutnovsky hydrothermal system. Probable mechanism of opals formation within the North Mutnovskaya zone is considered, and its characteristics are compared to those from the opal field Raduzhnoye, Primorye

The Conditions of Opal Formation within the North-Mutnovskaya Volcanic Zone of Kamchatka

The characteristics of formation of the opal mineralization in the host rock within Mutnovskaya volcanic zone were studied. The type of metasomatic rock alteration and its consecutive order were established. The results of study allowed identifying the mineral inclusions in opals, which was linked to the metalliferousness of the Mutnovsky hydrothermal system. Probable mechanism of opals formation within the North Mutnovskaya zone is considered, and its characteristics are compared to those from the opal field Raduzhnoye, Primorye

DICER and DROSHA gene expression in peripheral mononuclear blood cells from rheumatoid arthritis patients under methotrexate therapy

The aim of this research was studying the level of DROSHA and DICER genes expression in peripheral mononuclear blood cells (PBMC) in rheumatoid arthritis (RA) patients under methotrexate therapy. Materials and methods. 82 people (from 45 to 70 years) enrolled in this study were divided into 3 groups (the first one - healthy donors (n=33 median age 49.93±1.87); the second group - rheumatoid arthritis patients without any therapy (n=15; median age 57.28±15.18) and the third group (n=34; median age 60.88±9.02) - rheumatoid arthritis patients who treated at least 4 weeks with methotrexate therapy (10-20 mg/week). The DICER and DROSHA genes expression level was determined by real-time PCR. Results. The number of DICER gene transcripts in PBMC in rheumatoid arthritis patients without therapy as in RA patients treated with methotrexate was reduced in comparison with the healthy donors (p0.05 respectively). The level of DROSHA gene expression in PBMC was not significantly different in all groups enrolled in this study (p>0.05). Conclusion. Our findings suggest that that the DICER gene expression level in perifheral mononuclear blood cells decreased with the development of rheumatoid arthritis. Methotrexate doesn’t influence on the mRNA level of this gene

ASSOCIATION OF rs4537545 (C>T) ALLELE POLYMORPHISM IN THE IL6R GENE WITH THE DEVELOPMENT OF RHEUMATOID ARTHRITIS

Objective: to analyze the association of the polymorphic marker rs4537545 (C>T) in the IL6R gene with the development of rheumatoid arthritis (RA) in the population of the Republic of Karelia. Subjects and methods. The investigation included 190 samples of DNA extracted from the whole blood of healthy individuals and 158 samples from patients with RA. Genotyping was performed using a polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis. The expression level of IL6 and IL6R genes in peripheral blood leukocytes (PBLs) from healthy individuals was assessed by real-time PCR. The plasma content of interleukin-6 (IL-6) in healthy donors was measured by enzyme-linked immunosorbent assay (ELISA). Results and discussion. An association of the polymorphic marker rs4537545 (C>T) in the IL6R gene with the development of rheumatoid arthritis was found in the population of the Republic of Karelia. The risk of RA in the persons carrying the T-allele of rs4537545 in the genotypes was 2.1 times higher than that in the C-allele carriers (odds ratio (OR), 2.103; 95% confidence interval, 1.032-4.287). The genotypes were ascertained to have an effect on the level of IL6R gene in PBL and on the plasma content of IL-6 in the healthy donors. Conclusion. The polymorphic marker rs4537545 (C>T) in the IL6R gene is involved in the genetic predisposition of humans to RA development through modulation of the level of transcriptional activity of the IL6R gene and the content of IL-6