Towards Drift Correction in Chemical Sensors Using an Evolutionary Strategy

Gas chemical sensors are strongly affected by the so-called drift, i.e., changes in sensors' response caused by poisoning and aging that may significantly spoil the measures gathered. The paper presents a mechanism able to correct drift, that is: delivering a correct unbiased fingerprint to the end user. The proposed system exploits a state-of-the-art evolutionary strategy to iteratively tweak the coefficients of a linear transformation. The system operates continuously. The optimal correction strategy is learnt without a-priori models or other hypothesis on the behavior of physical-chemical sensors. Experimental results demonstrate the efficacy of the approach on a real problem

Biocompatible electrospun polycaprolactone-polyaniline scaffold treated with atmospheric plasma to improve hydrophilicity

Conductive polymers (CPs) have recently been applied in the development of scaffolds for tissue engineering applications in attempt to induce additional cues able to enhance tissue growth. Polyaniline (PANI) is one of the most widely studied CPs, but it requires to be blended with other polymers in order to be processed through conventional technologies. Here, we propose the fabrication of nanofibers based on a polycaprolactone (PCL)-PANI blend obtained using electro-spinning technology. An extracellular matrix-like fibrous substrate was obtained showing a good stability in the physiological environment (37 °C in PBS solution up 7 days). However, since the high hydrophobicity of the PCL-PANI mats (133.5 ± 2.2°) could negatively affect the biological re-sponse, a treatment with atmospheric plasma was applied on the nanofibrous mats, obtaining a hydrophilic surface (67.1 ± 2°). In vitro tests were performed to confirm the viability and the physi-ological-like morphology of human foreskin fibroblast (HFF-1) cells cultured on the plasma treated PCL-PANI nanofibrous scaffolds

Discussion Paper for Regional Consultations on the Implementation of the United Nations Environment Assembly Resolution on Mineral Resource Governance (UNEP/EA.4/Res. 19)

This discussion paper is prepared to support regional consultations held on the implementation of the United Nations Environment Assembly\ua0resolution on Mineral Resource Governance.\ua0The discussion paper summarises global trends in minerals\ua0and sustainable development and presents key findings from recent studies of mineral governance\ua0developed by UNEP and others. Options for the governance of minerals and lessons from best practices are also discussed. Questions are posed for consideration during consultations and future action on the topic. Findings from the regional consultations will feed into the report on the implementation of the resolution, which will be presented to the UNEA at its fifth session in February 2021

Towards 3d multi-layer scaffolds for periodontal tissue engineering applications: Addressing manufacturing and architectural challenges

Reduced periodontal support, deriving from chronic inflammatory conditions, such as periodontitis, is one of the main causes of tooth loss. The use of dental implants for the replacement of missing teeth has attracted growing interest as a standard procedure in clinical practice. However, adequate bone volume and soft tissue augmentation at the site of the implant are important prerequisites for successful implant positioning as well as proper functional and aesthetic reconstruction of patients. Three-dimensional (3D) scaffolds have greatly contributed to solve most of the challenges that traditional solutions (i.e., autografts, allografts and xenografts) posed. Nevertheless, mimicking the complex architecture and functionality of the periodontal tissue represents still a great challenge. In this study, a porous poly(ε-caprolactone) (PCL) and Sr-doped nano hydroxyapatite (Sr-nHA) with a multi-layer structure was produced via a single-step additive manufacturing (AM) process, as a potential strategy for hard periodontal tissue regeneration. Physicochemical characterization was conducted in order to evaluate the overall scaffold architecture, topography, as well as porosity with respect to the original CAD model. Furthermore, compressive tests were performed to assess the mechanical properties of the resulting multi-layer structure. Finally, in vitro biological performance, in terms of biocompatibility and osteogenic potential, was evaluated by using human osteosarcoma cells. The manufacturing route used in this work revealed a highly versatile method to fabricate 3D multi-layer scaffolds with porosity levels as well as mechanical properties within the range of dentoalveolar bone tissue. Moreover, the single step process allowed the achievement of an excellent integrity among the different layers of the scaffold. In vitro tests suggested the promising role of the ceramic phase within the polymeric matrix towards bone mineralization processes. Overall, the results of this study demonstrate that the approach undertaken may serve as a platform for future advances in 3D multi-layer and patient-specific strategies that may better address complex periodontal tissue defects

Parental education and text messaging reminders as effective community based tools to increase HPV vaccination rates among Mexican American children

AbstractObjectiveLatino populations, particularly Mexican-Americans who comprise 65% of the Latinos in the U.S., are disproportionately affected by HPV-related diseases. The HPV vaccination completion rates remain low, well below the Healthy People 2020 goal. In this study we assessed the effect of parental education and a text messaging reminder service on HPV vaccine completion rates among eligible children of Mexican American parents.Study designNonequivalent group study of Mexican parents of HPV vaccine eligible children attended the Health Window program at the Mexican Consulate in New York City, a non-clinical, trusted community setting, during 2012–2013. 69 parents received HPV education onsite, 45 of whom also received a series of text message vaccination reminders. We measured HPV vaccination completion of the youngest eligible children of Mexican parents as the main outcome.Results98% of those in the education plus text messaging group reported getting the first dose of the vaccine for their child and 87% among those in the educational group only (p=0.11). 88% of those receiving the 1st dose in the text messaging group reported completing the three doses versus 40% in the educational group only (p=0.004).ConclusionsParental text messaging plus education, implemented in a community based setting, was strongly associated with vaccine completion rates among vaccine-eligible Mexican American children. Although pilot in nature, the study achieved an 88% series completion rate in the children of those who received the text messages, significantly higher than current vaccination levels

Chitosan-based hydrogel to support the paracrine activity of mesenchymal stem cells in spinal cord injury treatment

Abstract Advanced therapies which combine cells with biomaterial-based carriers are recognized as an emerging and powerful method to treat challenging diseases, such as spinal cord injury (SCI). By enhancing transplanted cell survival and grafting, biomimetic hydrogels can be properly engineered to encapsulate cells and locate them at the injured site in a minimally invasive way. In this work, chitosan (CS) based hydrogels were developed to host mesenchymal stem cells (MSCs), since their paracrine action can therapeutically enhance the SC regeneration, limiting the formation of a glial scar and reducing cell death at the injured site. An injectable and highly permeable CS-based hydrogel was fabricated having a rapid gelation upon temperature increase from 0 to 37 °C. CS was selected as former material both for its high biocompatibility that guarantees the proper environment for MSCs survival and for its ability to provide anti-inflammatory and anti-oxidant cues. MSCs were mixed with the hydrogel solution prior to gelation. MSC viability was not affected by the CS hydrogel and encapsulated MSCs were able to release MSC-vesicles as well as to maintain their anti-oxidant features. Finally, preliminary in vivo tests on SCI mice revealed good handling of the CS solution loading MSCs during implantation and high encapsulated MSCs survival after 7 days

L’utilizzo delle protesi endoscopiche nella patologia dell’apparato digerente

L’utilizzo di protesi ad introduzione per via endoscopica per patologie dell’apparato digerente sia benigne che maligne ha avuto negli ultimi anni un considerevole sviluppo. Il posizionamento delle endoprotesi è ben tollerato dai pazienti, non necessita di anestesia e comporta rischi relativamente minimi. Le nuove protesi metalliche autoespansibili permettono di risolvere stenosi anche molto serrate senza quasi mai necessità di dilatazione, con riduzione dei rischi che da questa derivano. Viene riportata una revisione dell’esperienza di protesizzazione per patologie dell’apparato digerente e vengono discussi le indicazioni, i limiti e le complicanze, sulla scorta dei dati dalla letteratura internazionale

Automated Playtesting in Collectible Card Games using Evolutionary Algorithms: a Case Study in HearthStone

Collectible card games have been among the most popular and profitable products of the entertainment industry since the early days of Magic: The GatheringTM in the nineties. Digital versions have also appeared, with HearthStone: Heroes of WarCraftTM being one of the most popular. In Hearthstone, every player can play as a hero, from a set of nine, and build his/her deck before the game from a big pool of available cards, including both neutral and hero-specific cards. This kind of games offers several challenges for researchers in artificial intelligence since they involve hidden information, unpredictable behaviour, and a large and rugged search space. Besides, an important part of player engagement in such games is a periodical input of new cards in the system, which mainly opens the door to new strategies for the players. Playtesting is the method used to check the new card sets for possible design flaws, and it is usually performed manually or via exhaustive search; in the case of Hearthstone, such test plays must take into account the chosen hero, with its specific kind of cards. In this paper, we present a novel idea to improve and accelerate the playtesting process, systematically exploring the space of possible decks using an Evolutionary Algorithm (EA). This EA creates HearthStone decks which are then played by an AI versus established human-designed decks. Since the space of possible combinations that are play-tested is huge, search through the space of possible decks has been shortened via a new heuristic mutation operator, which is based on the behaviour of human players modifying their decks. Results show the viability of our method for exploring the space of possible decks and automating the play-testing phase of game design. The resulting decks, that have been examined for balancedness by an expert player, outperform human-made ones when played by the AI; the introduction of the new heuristic operator helps to improve the obtained solutions, and basing the study on the whole set of heroes shows its validity through the whole range of decks