Growth of Ring-shaped Edge Cracks under Reversed Torsional Fatigue

Mode III fatigue crack growth was studied using cylindrical specimens with ring-shaped edge cracks under reversed torsion. Cracks grew locally in Mode I making small branches but their macroscopic growth direction was perpendicular to the specimen axis. The crack depth was successively estimated by the compliance calibration method and the growth rate of torsional cracks was related to the applied stress intensity factor range ΔK_. In torsion, friction must be considered together with mutual sliding of pre-fatigue crack surfaces. Consequently, the applied torsional torque should be modified in evaluating the effective stress intensity factor. Effect of the surface friction on the stress state around the crack tip was examined by an elastic-plastic finite element analysis

A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

This study describes RK-701, an inhibitor of histone methyltransferases G9a/GLP, as a promising therapeutic candidate for sickle cell disease and a universal role of BGLT3 lncRNA in fetal hemoglobin reactivation by chemical inducers including RK-701