Modeling and computation of an integral operator Riccati equation for an infinite-dimensional stochastic differential equation governing streamflow discharge

We propose a linear-quadratic (LQ) control problem of streamflow discharge by optimizing an infinite-dimensional jump-driven stochastic differential equation (SDE). Our SDE is a superposition of Ornstein-Uhlenbeck processes (supOU process), generating a sub-exponential autocorrelation function observed in actual data. The integral operator Riccati equation is heuristically derived to determine the optimal control of the infinite-dimensional system. In addition, its finite-dimensional version is derived with a discretized distribution of the reversion speed and computed by a finite difference scheme. The optimality of the Riccati equation is analyzed by a verification argument. The supOU process is parameterized based on the actual data of a perennial river. The convergence of the numerical scheme is analyzed through computational experiments. Finally, we demonstrate the application of the proposed model to realistic problems along with the Kolmogorov backward equation for the performance evaluation of controls

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

「コロナ制圧タスクフォース」COVID-19患者由来の血液細胞における遺伝子発現の網羅的解析 --重症度に応じた遺伝子発現の変化には、ヒトゲノム配列の個人差が影響する--. 京都大学プレスリリース. 2022-08-23.Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, studies of gene expression dynamics and regulation landscape in COVID-19 infected individuals are limited. Here, we report on a thorough analysis of whole blood RNA-seq data from 465 genotyped samples from the Japan COVID-19 Task Force, including 359 severe and 106 non-severe COVID-19 cases. We discover 1169 putative causal expression quantitative trait loci (eQTLs) including 34 possible colocalizations with biobank fine-mapping results of hematopoietic traits in a Japanese population, 1549 putative causal splice QTLs (sQTLs; e.g. two independent sQTLs at TOR1AIP1), as well as biologically interpretable trans-eQTL examples (e.g., REST and STING1), all fine-mapped at single variant resolution. We perform differential gene expression analysis to elucidate 198 genes with increased expression in severe COVID-19 cases and enriched for innate immune-related functions. Finally, we evaluate the limited but non-zero effect of COVID-19 phenotype on eQTL discovery, and highlight the presence of COVID-19 severity-interaction eQTLs (ieQTLs; e.g., CLEC4C and MYBL2). Our study provides a comprehensive catalog of whole blood regulatory variants in Japanese, as well as a reference for transcriptional landscapes in response to COVID-19 infection

DOCK2 is involved in the host genetics and biology of severe COVID-19

「コロナ制圧タスクフォース」COVID-19疾患感受性遺伝子DOCK2の重症化機序を解明 --アジア最大のバイオレポジトリーでCOVID-19の治療標的を発見--. 京都大学プレスリリース. 2022-08-10.Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge. Here we conducted a genome-wide association study (GWAS) involving 2, 393 cases of COVID-19 in a cohort of Japanese individuals collected during the initial waves of the pandemic, with 3, 289 unaffected controls. We identified a variant on chromosome 5 at 5q35 (rs60200309-A), close to the dedicator of cytokinesis 2 gene (DOCK2), which was associated with severe COVID-19 in patients less than 65 years of age. This risk allele was prevalent in East Asian individuals but rare in Europeans, highlighting the value of genome-wide association studies in non-European populations. RNA-sequencing analysis of 473 bulk peripheral blood samples identified decreased expression of DOCK2 associated with the risk allele in these younger patients. DOCK2 expression was suppressed in patients with severe cases of COVID-19. Single-cell RNA-sequencing analysis (n = 61 individuals) identified cell-type-specific downregulation of DOCK2 and a COVID-19-specific decreasing effect of the risk allele on DOCK2 expression in non-classical monocytes. Immunohistochemistry of lung specimens from patients with severe COVID-19 pneumonia showed suppressed DOCK2 expression. Moreover, inhibition of DOCK2 function with CPYPP increased the severity of pneumonia in a Syrian hamster model of SARS-CoV-2 infection, characterized by weight loss, lung oedema, enhanced viral loads, impaired macrophage recruitment and dysregulated type I interferon responses. We conclude that DOCK2 has an important role in the host immune response to SARS-CoV-2 infection and the development of severe COVID-19, and could be further explored as a potential biomarker and/or therapeutic target

光バーストスイッチネットワークにおける波長選択方式に関する研究

University of Tokyo (東京大学

Simulation of Mechanical Characteristics of Tennis Racket String Bed Considering String Pattern

The effect of string pattern on the mechanical characteristics of a tennis racket were simulated numerically. A numerical simulation program to evaluate deformation of the string bed of a tennis racket was developed using the finite element method. The formulation of a numerical simulation code is described in this paper. The applicability of the developed simulation program was investigated by comparing experimental results of loading tests on string bed specimens, for which the distance between strings was 12 mm. The out-of-plane stiffness and sliding characteristics of strings of an actual racket were simulated using the developed simulation code

Burst Assembly Mechanism with Delay Reduction for OBS Networks

In this paper, we present a novel burst assembly approach for delay reduction in optical burst switched networks. The main idea of our approach is to send a control signal before burst data is completely assembled. This approach can reduce the burst buffering delay at an edge node compared with existing methods. Estimation results show that burst buffering delay is reduced and needless bandwidth reservation is prevented

Protocol Protocols Protocol and Experiment Experiments Experiment

In the future network, optical technology will play a stronger role not only for transmission but also for switching. Optical burst switching (OBS) emerged as a promising switching paradigm. It brings together the complementary strengths of optics and electronics. This paper presents the design and implementation of an overlay mode burst-switched photonic network testbed, including its architecture, protocols, algorithms and experiments. We propose a flexible “transceiver + forwarding ” OBS node architecture to perform both electronic burst assembly/disassembly and optical burst forwarding. It has been designed to provide class of service (CoS), wavelength selection for local bursts, and transparency to cut-through bursts. The functional modules of OBS control plane and its key design issues are presented, including signaling, routing, and a novel scheduling mechanism with combined contention resolution in space and wavelength domains. Finally, we report the experimental results on functional verification, performance analysis and service demonstration. Key words: Photonic Internet, optical burst switching (OBS), wavelength selection, burst scheduling, contention resolution 1