28 research outputs found
Intramolecular 2-Propylidene-1,3-bis(silane) Imine Cyclizations. An Efficient New Procedure for the Stereocontrolled Synthesis of Pyrrolidines, Isotropanes, and Bridged Pyrrolizidines â€
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A Stereocontrolled Synthesis of (±)-Xenovenine via a Scandium(III)-Catalyzed Internal Aminodiene Bicyclization Terminated by a 2-(5-Ethyl-2-thienyl)ethenyl Group
No full textSynthetic Utility of Organometallic Reagents Derived from Group IV Metal Tetrachlorides and CH 3
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Intramolecular Cyclizations of Imines Bearing the 2-(Thiomethyl)-3-trimethylsilyl-1-propenyl Terminator. An Efficient New Procedure for the Stereocontrolled Synthesis of Functionalized Pyrrolidine Derivatives
No full textTitanium-Catalyzed Cycloisomerization of 1,6-Dienes. Regio- and Stereoselective Synthesis of e
No full textFormation of episulfonium ions from alkenes. Application to the synthesis of higher order carbocycles via episulfonium ion initiated polyene cyclizations
No full textCopper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents
No full textNitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration. The treatment of N,N-dimethylhydrazinoalkenes with Et2Zn, followed by a Cu(I)-catalyzed cross-coupling with 1-bromoalkynes, results in piperidines and pyrrolidines with a good yield. Five examples are reported and a proposed mechanism for the Cu(I)-catalyzed cross-coupling is presented
