Large orders in strong-field QED

We address the issue of large-order expansions in strong-field QED. Our approach is based on the one-loop effective action encoded in the associated photon polarisation tensor. We concentrate on the simple case of crossed fields aiming at possible applications of high-power lasers to measure vacuum birefringence. A simple next-to-leading order derivative expansion reveals that the indices of refraction increase with frequency. This signals normal dispersion in the small-frequency regime where the derivative expansion makes sense. To gain information beyond that regime we determine the factorial growth of the derivative expansion coefficients evaluating the first 80 orders by means of computer algebra. From this we can infer a nonperturbative imaginary part for the indices of refraction indicating absorption (pair production) as soon as energy and intensity become (super)critical. These results compare favourably with an analytic evaluation of the polarisation tensor asymptotics. Kramers-Kronig relations finally allow for a nonperturbative definition of the real parts as well and show that absorption goes hand in hand with anomalous dispersion for sufficiently large frequencies and fields.Comment: 26 pages, 6 figure

Association between inflammation and neural plasticity biomarkers in olfactory neuroepithelium – derived cells and cognitive performance in patients with major depressive disorder

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Optimal Economic Growth under Stochastic Environmental Impact: Sensitivity Analysis

In this work we present an approach toward the sensitivity analysis of optimal economic growth to a negative environmental impact driven by random natural hazards that damage the production output . We use a simplified model of the GDP whose growth leads to the increase of GHG in the atmosphere provided investment in cleaning is insufficient. The hypothesis of the Poisson probability distribution of the natural hazards is used at the first stage of the research. We apply the standard utility function - the discounted integral consumption and construct an optimal investment policy in production and cleaning together with optimal GDP trajectories. We calibrate the model in the global scale and analyze the sensitivity of obtained optimal growth scenarios with respect to uncertain parameters of the Poisson distribution

External Fields as a Probe for Fundamental Physics

Quantum vacuum experiments are becoming a flexible tool for investigating fundamental physics. They are particularly powerful for searching for new light but weakly interacting degrees of freedom and are thus complementary to accelerator-driven experiments. I review recent developments in this field, focusing on optical experiments in strong electromagnetic fields. In order to characterize potential optical signatures, I discuss various low-energy effective actions which parameterize the interaction of particle-physics candidates with optical photons and external electromagnetic fields. Experiments with an electromagnetized quantum vacuum and optical probes do not only have the potential to collect evidence for new physics, but special-purpose setups can also distinguish between different particle-physics scenarios and extract information about underlying microscopic properties.Comment: 12 pages, plenary talk at QFEXT07, Leipzig, September 200

Can Light Signals Travel Faster than c in Nontrivial Vacuua in Flat space-time? Relativistic Causality II

In this paper we show that the Scharnhorst effect (Vacuum with boundaries or a Casimir type vacuum) cannot be used to generate signals showing measurable faster-than-c speeds. Furthermore, we aim to show that the Scharnhorst effect would violate special relativity, by allowing for a variable speed of light in vacuum, unless one can specify a small invariant length scale. This invariant length scale would be agreed upon by all inertial observers. We hypothesize the approximate scale of the invariant length.Comment: 12 pages no figure

Axions, their Relatives and Prospects for the Future

The observation of a non-vanishing rotation of linear polarized laser light after passage through a strong magnetic field by the PVLAS collaboration has renewed the interest in light particles coupled to photons. Axions are a species of such particles that is theoretically well motivated. However, the relation between coupling and mass predicted by standard axion models conflicts with the PVLAS observation. Moreover, light particles with a coupling to photons of the strength required to explain PVLAS face trouble from astrophysical bounds. We discuss models that can avoid these bounds. Finally, we present some ideas to test these possible explanations of PVLAS experimentally.Comment: 11 pages, 4 figures. Contributed to the ``Third Symposium on Large TPCs for Low Energy Rare Event Detection'' in Paris, December 200

BU08073 a buprenorphine analog with partial agonist activity at μ-receptors <em> in vitro </em>but long-lasting opioid antagonist activity <i>in vivo</i> in mice

BACKGROUND AND PURPOSE: Buprenorphine is a potent analgesic with high affinity at μ, δ and κ and moderate affinity at nociceptin opioid (NOP) receptors. Nevertheless, NOP receptor activation modulates the in vivo activity of buprenorphine. Structure activity studies were conducted to design buprenorphine analogues with high affinity at each of these receptors and to characterize them in in vitro and in vivo assays. EXPERIMENTAL APPROACH: Compounds were tested for binding affinity and functional activity using [(35)S]GTPγS binding at each receptor and a whole-cell fluorescent assay at μ receptors. BU08073 was evaluated for antinociceptive agonist and antagonist activity and for its effects on anxiety in mice. KEY RESULTS: BU08073 bound with high affinity to all opioid receptors. It had virtually no efficacy at δ, κ and NOP receptors, whereas at μ receptors, BU08073 has similar efficacy as buprenorphine in both functional assays. Alone, BU08073 has anxiogenic activity and produces very little antinociception. However, BU08073 blocks morphine and U50,488-mediated antinociception. This blockade was not evident at 1 h post-treatment, but is present at 6 h and remains for up to 3–6 days. CONCLUSIONS AND IMPLICATIONS: These studies provide structural requirements for synthesis of ‘universal’ opioid ligands. BU08073 had high affinity for all the opioid receptors, with moderate efficacy at μ receptors and reduced efficacy at NOP receptors, a profile suggesting potential analgesic activity. However, in vivo, BU08073 had long-lasting antagonist activity, indicating that its pharmacokinetics determined both the time course of its effects and what receptor-mediated effects were observed. LINKED ARTICLES: This article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-

Search for Doubly-Charged Higgs Boson Production at HERA

A search for the single production of doubly-charged Higgs bosons H^{\pm \pm} in ep collisions is presented. The signal is searched for via the Higgs decays into a high mass pair of same charge leptons, one of them being an electron. The analysis uses up to 118 pb^{-1} of ep data collected by the H1 experiment at HERA. No evidence for doubly-charged Higgs production is observed and mass dependent upper limits are derived on the Yukawa couplings h_{el} of the Higgs boson to an electron-lepton pair. Assuming that the doubly-charged Higgs only decays into an electron and a muon via a coupling of electromagnetic strength h_{e \mu} = \sqrt{4 \pi \alpha_{em}} = 0.3, a lower limit of 141 GeV on the H^{\pm\pm} mass is obtained at the 95% confidence level. For a doubly-charged Higgs decaying only into an electron and a tau and a coupling h_{e\tau} = 0.3, masses below 112 GeV are ruled out.Comment: 15 pages, 3 figures, 1 tabl