30 research outputs found
Dose- and time-dependent cytotoxicity of HCFC-123 and HCFC-141b on isolated rat hepatocytes under aerobic and hypoxic conditions
No full textCytochrome P450 inactivation during reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) by phenobarbital- and pyridine-induced rat liver microsomes
No full textReductive inactivation of microsomal cytochrome P450 by 1,1-Dichloro-2,2,2-Trifluoroethane (HCFC-123)
No full textChytochrome P450 inactivation during reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) by phenobarbital and pyridine-induced rat liver microsomes.
No full textThe paper reports, for the first time, the suicidal inactivation of cytochrome P450 during the reductive metabolism of 1,1-dichloro-2,2,2-trifluoroethane by rat liver microsomes under anaerobic conditions
Reductive activation of halothane by human haemoglobin results in the modification of the prosthetic haem.
No full textThe paper reports the mechanism of the original observation that human haemoglobin may reductively activate the anaesthetic halothane, resulting in the irreversible inactivation of the prosthetic haem moiety
Cytochrome P450-dependent activation of HCFC-123 and HCFC-141b to cytotoxic free radicals
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Bioactivation to free radicals and cytotoxicity of 1,1-dichloro-1-fluoroethane (HCFC-141b).
No full text
