Expression of the RAE-1 Family of Stimulatory NK-Cell Ligands Requires Activation of the PI3K Pathway during Viral Infection and Transformation

Natural killer (NK) cells are lymphocytes that play a major role in the elimination of virally-infected cells and tumor cells. NK cells recognize and target abnormal cells through activation of stimulatory receptors such as NKG2D. NKG2D ligands are self-proteins, which are absent or expressed at low levels on healthy cells but are induced upon cellular stress, transformation, or viral infection. The exact molecular mechanisms driving expression of these ligands remain poorly understood. Here we show that murine cytomegalovirus (MCMV) infection activates the phosphatidylinositol-3-kinase (PI3K) pathway and that this activation is required for the induction of the RAE-1 family of mouse NKG2D ligands. Among the multiple PI3K catalytic subunits, inhibition of the p110α catalytic subunit blocks this induction. Similarly, inhibition of p110α PI3K reduces cell surface expression of RAE-1 on transformed cells. Many viruses manipulate the PI3K pathway, and tumors frequently mutate the p110α oncogene. Thus, our findings suggest that dysregulation of the PI3K pathway is an important signal to induce expression of RAE-1, and this may represent a commonality among various types of cellular stresses that result in the induction of NKG2D ligands

Qubit Decoherence and Non-Markovian Dynamics at Low Temperatures via an Effective Spin-Boson Model

Quantum Brownian oscillator model (QBM), in the Fock-space representation, can be viewed as a multi-level spin-boson model. At sufficiently low temperature, the oscillator degrees of freedom are dynamically reduced to the lowest two levels and the system behaves effectively as a two-level (E2L) spin-boson model (SBM) in this limit. We discuss the physical mechanism of level reduction and analyze the behavior of E2L-SBM from the QBM solutions. The availability of close solutions for the QBM enables us to study the non-Markovian features of decoherence and leakage in a SBM in the non-perturbative regime (e.g. without invoking the Born approximation) in better details than before. Our result captures very well the characteristic non-Markovian short time low temperature behavior common in many models.Comment: 19 pages, 8 figure

Time-convolutionless reduced-density-operator theory of a noisy quantum channel: a two-bit quantum gate for quantum information processing

An exact reduced-density-operator for the output quantum states in time-convolutionless form was derived by solving the quantum Liouville equation which governs the dynamics of a noisy quantum channel by using a projection operator method and both advanced and retarded propagators in time. The formalism developed in this work is general enough to model a noisy quantum channel provided specific forms of the Hamiltonians for the system, reservoir, and the mutual interaction between the system and the reservoir are given. Then, we apply the formulation to model a two-bit quantum gate composed of coupled spin systems in which the Heisenberg coupling is controlled by the tunneling barrier between neighboring quantum dots. Gate Characteristics including the entropy, fidelity, and purity are calculated numerically for both mixed and entangled initial states

Diffusive Evolution of Stable and Metastable Phases II: Theory of Non-Equilibrium Behaviour in Colloid-Polymer Mixtures

By analytically solving some simple models of phase-ordering kinetics, we suggest a mechanism for the onset of non-equilibrium behaviour in colloid-polymer mixtures. These mixtures can function as models of atomic systems; their physics therefore impinges on many areas of thermodynamics and phase-ordering. An exact solution is found for the motion of a single, planar interface separating a growing phase of uniform high density from a supersaturated low density phase, whose diffusive depletion drives the interfacial motion. In addition, an approximate solution is found for the one-dimensional evolution of two interfaces, separated by a slab of a metastable phase at intermediate density. The theory predicts a critical supersaturation of the low-density phase, above which the two interfaces become unbound and the metastable phase grows ad infinitum. The growth of the stable phase is suppressed in this regime.Comment: 27 pages, Latex, eps

Aspects of the dynamics of colloidal suspensions: Further results of the mode-coupling theory of structural relaxation

Results of the idealized mode-coupling theory for the structural relaxation in suspensions of hard-sphere colloidal particles are presented and discussed with regard to recent light scattering experiments. The structural relaxation becomes non-diffusive for long times, contrary to the expectation based on the de Gennes narrowing concept. A semi-quantitative connection of the wave vector dependences of the relaxation times and amplitudes of the final $\alpha$-relaxation explains the approximate scaling observed by Segr{\`e} and Pusey [Phys. Rev. Lett. {\bf 77}, 771 (1996)]. Asymptotic expansions lead to a qualitative understanding of density dependences in generalized Stokes-Einstein relations. This relation is also generalized to non-zero frequencies thereby yielding support for a reasoning by Mason and Weitz [Phys. Rev. Lett {\bf 74}, 1250 (1995)]. The dynamics transient to the structural relaxation is discussed with models incorporating short-time diffusion and hydrodynamic interactions for short times.Comment: 11 pages, 9 figures; to be published in Phys. Rev.

Langevin Equation for the Rayleigh model with finite-ranged interactions

Both linear and nonlinear Langevin equations are derived directly from the Liouville equation for an exactly solvable model consisting of a Brownian particle of mass $M$ interacting with ideal gas molecules of mass $m$ via a quadratic repulsive potential. Explicit microscopic expressions for all kinetic coefficients appearing in these equations are presented. It is shown that the range of applicability of the Langevin equation, as well as statistical properties of random force, may depend not only on the mass ratio $m/M$ but also by the parameter $Nm/M$, involving the average number $N$ of molecules in the interaction zone around the particle. For the case of a short-ranged potential, when $N\ll 1$, analysis of the Langevin equations yields previously obtained results for a hard-wall potential in which only binary collisions are considered. For the finite-ranged potential, when multiple collisions are important ($N\gg 1$), the model describes nontrivial dynamics on time scales that are on the order of the collision time, a regime that is usually beyond the scope of more phenomenological models.Comment: 21 pages, 1 figure. To appear in Phys. Rev.

Crystal constructions in Number Theory

Weyl group multiple Dirichlet series and metaplectic Whittaker functions can be described in terms of crystal graphs. We present crystals as parameterized by Littelmann patterns and we give a survey of purely combinatorial constructions of prime power coefficients of Weyl group multiple Dirichlet series and metaplectic Whittaker functions using the language of crystal graphs. We explore how the branching structure of crystals manifests in these constructions, and how it allows access to some intricate objects in number theory and related open questions using tools of algebraic combinatorics

Effect of temperature on rheology behaviour of banana peel pectin extracted using hot compressed water

Banana peel pectin is extracted from banana peel waste using a hot compressed water extraction (140-160°C, 5 minutes, 1.18 mm particle size). Physicochemical contents of banana peel pectin were found to be in a similar range with commercial pectin, and is comprised of moisture (7.44-8.47%), ash (3.45-4.98%), protein (1.08-1.92%), fat (0.04-3.42), carbohydrate (83-86%), total sugar (1.77-3.41%), energy (353-369 kcal/100g) and specific heat (1.42-1.62 kJ/kg°C). These contents possibly related to their flow deformation of rheological behaviour. Regression analysis displayed good agreements in all models applied, apart from the Casson Model. Flow behaviour indices, n<1 and decreasing of apparent viscosity within increasing of shear rate indicates that banana peel pectin has excellent shear thinning behaviour with a presence of yield stress

Renormalization Theory of Stochastic Growth

An analytical renormalization group treatment is presented of a model which, for one value of parameters, is equivalent to diffusion limited aggregation. The fractal dimension of DLA is computed to be 2-1/2+1/5=1.7. Higher multifractal exponents are also calculated and found in agreement with numerical results. It may be possible to use this technique to describe the dielectric breakdown model as well, which is given by different parameter values.Comment: 39 pages, LaTeX, 11 figure