歯の形態形成に関与する新規遺伝子の解明

Tooth development is controlled by body plan during the fetal period, the generation of teeth from tooth germ is induced by the epithelial-mesenchymal interaction. Spatiotemporal regulation of tooth morphogenesis is supported by gene expression. Although many of the genes involved in tooth development are known, the molecular mechanism underlying tooth morphogenesis is not completely understood. For a comprehensive understanding of tooth development, the elucidation of unknown genes is necessary. In this study, to identify unknown genes involved in tooth development, we performed genome-wide analysis at each stage of tooth development and identified 17 genes with high levels of expression and large changes in expression. In addition, we performed qPCR and in situ hybridization analyses to elucidate the spatiotemporal regulation, such as the regulation that occurs around or in the entire tooth germ, enamel knots, epithelium, and mesenchyme. These results show that these characteristic genes may play important roles in each time period or region of tooth development, and the elucidation of the functions of these genes will lead to an integrated understanding of the process of tooth development.博士（医学）・甲第790号・令和3年3月15日発行元である日本再生歯科医学会の許諾を得て登録（2021年6月29日付）ジャーナル公式サイト（日本再生歯科医学会HP内）：http://www.jarde.jp/zasshi/e/18-2-1.htm