Tissue factor expression in breast cancer tissues: its correlation with prognosis and plasma concentration

Tissue factor (TF), an initiator of the extrinsic coagulation cascade, is expressed in a wide range of cancer cells and plays important roles in cancer progression and metastasis. Recently, the intracellular function of TF has been revealed to be involved in cancer invasion, independent of the blood coagulation pathway. To evaluate the clinical significance of TF expression, we performed an enzyme-linked immunosorbent assay (ELISA) in the plasma of 67 breast cancer patients and immunohistochemistry in 213 breast cancer tissues. In the ELISA study, we showed an up-regulation of plasma TF concentration in breast cancer patients compared with normal controls. Immunohistochemistry demonstrated that TF was expressed in tumour cells and stromal cells and tumour TF expression closely correlated with stromal TF expression (P = 0.0005). The concentration of plasma TF was associated with tissue TF expression in both tumour and stroma. The multivariate analysis demonstrated that tumour TF expression was an independent prognostic indicator for overall survival (P = 0.0452). Our data show that plasma TF concentration reflects tissue TF expression and tumour TF expression can provide some predictive value for prognosis and distant metastasis, which indicates the importance of TF function in tumour progression. © 2000 Cancer Research Campaig

Extension of geodesic acoustic mode theory to helical systems

The present paper extends the theory of geodesic acoustic mode (GAM) oscillation, which so far has been applied to tokamaks, to helical systems. By using drift kinetic equations for three-dimensional equilibriums, a generalized dispersion relation is obtained including Landau damping. The oscillation frequency is obtained in terms of the squared sum of Fourier components of the magnetic field intensity expressed by means of magnetic flux coordinates. An analytic form of the collisionless damping rate of GAM is obtained by solving the dispersion relation perturbatively. It is found that the GAM frequency is higher in helical systems than in tokamaks and that damping rate is enhanced in multi-helicity magnetic configurations. However, damping rates are predicted to be small if the temperature of electrons is higher than that of ions