34 research outputs found
Communication
This chapter discusses research on the
capacity and effectiveness of government’s
communications strategy as South Africa
went through the various stages of lockdown
during the Covid-19 pandemic in 2020. It
probes the working relationship between
communications from all spheres of
government and community, private, digital,
and social media, as well as organised civil
society before and during the lockdown and
assesses its impact and efficacy.
Recognising the multilingual nature of
South African society, the urban–rural
digital divide, and the prohibitive costs of
data, the chapter identifies lessons and
reaffirms the relevance of the development
communications approach to government–
citizen communications. It motivates for the prioritisation of accessible, multilingual digital
communications with a citizen feedback loop
that is transparent and responsive to ensure
people are informed and empowered, as
envisioned in the Constitution.
Such responsiveness needs an enabling
environment from government and from
the public, private, and community media
landscape. Collaboration and cooperation
across these sectors with government
communications and with the nongovernmental
health and communications
sectors is critical in such an all-encompassing
crisis. The chapter highlights the need to
continue to understand South Africa’s highly
diverse communication space, in which
digital new media platforms exist alongside
loudhailers, and make accommodations in
legislation, policy, and government coordination
with social partners to reach all people across
the digital, class, and language divides.This chapter 4 is published in the first edition of South Africa Covid-19 country report in June 2021.https://www.gov.za/sites/default/files/gcis_document/202206/sa-covid-19-reporta.pd
Epidemic of illicit drug use, mechanisms of action/addiction and stroke as a health hazard
Drug abuse robs individuals of their jobs, their families, and their free will as they succumb to addiction; but may cost even more: a life of disability or even life lost due to stroke. Many illicit drugs have been linked to major cardiovascular events and other comorbidities, including cocaine, amphetamines, ecstasy, heroin, phencyclidine, lysergic acid diethylamide, and marijuana. This review focuses on available epidemiological data, mechanisms of action, particularly those leading to cerebrovascular events, and it is based on papers published in English in PubMed during 1950 through February 2011. Each drug's unique interactions with the brain and vasculature predispose even young, healthy people to ischemic or hemorrhagic stroke. Cocaine and amphetamines have the strongest association with stroke. However, the level of evidence firmly linking other drugs to stroke pathogenesis is weak. Large epidemiological studies and systematic evaluation of each drug's action on the brain and cardiovascular system are needed to reveal the full impact of drug use on the population
Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to be involved in the etiology of pathological features of Alzheimer's disease (AD). Cannabidiol (CBD), a Cannabis derivative devoid of psychomimetic effects, has attracted much attention because of its promising neuroprotective properties in rat AD models, even though the mechanism responsible for such actions remains unknown. This study was aimed at exploring whether CBD effects could be subordinate to its activity at PPARγ, which has been recently indicated as its putative binding site. CBD actions on β-amyloid-induced neurotoxicity in rat AD models, either in presence or absence of PPAR antagonists were investigated. Results showed that the blockade of PPARγ was able to significantly blunt CBD effects on reactive gliosis and subsequently on neuronal damage. Moreover, due to its interaction at PPARγ, CBD was observed to stimulate hippocampal neurogenesis. All these findings report the inescapable role of this receptor in mediating CBD actions, here reported