Infective Endocarditis in Children — New Approach in Antimicrobial Prophylaxis

Infective endocarditis (IE) is an infection of the endocardium and/or heart valves with the formation of a thrombus and secondary damage of the involved tissue, with significant mortality and severe complications. The prevention of bacterial endocarditis is of great controversy. Antimicrobial prophylaxis is usable in the prevention of endocarditis by killing bacteria before or after their extension to the damaged endocardium. No human studies offer strong evidence to support the efficacy of antibiotic prophylaxis so far, thus it could be potentially dangerous. Therefore, the European Society of Cardiology (ESC) may need to reconsider and update the previous guidelines with the proposal of reducing the prophylactic approach of IE. The 2015 Task Force recommends prophylaxis for highest risk patients undergoing highest risk procedures, focused on prevention rather than prophylaxis of IE, especially in nosocomial endocarditis

Impaired Left Ventricular Longitudinal Function in Idiopathic Pulmonary Arterial Hypertension Children

Background: Pulmonary arterial hypertension is associated with right ventricular dilation and failure. As a result, left ventricular geometry is affected by shifting of the interventricular septum towards the left ventricle

Favorable Postoperative Evolution after Late Surgical Repair of Truncus Arteriosus Type 1: A Case Report

Truncus arteriosus communis (TA) is a rare cyanotic congenital heart defect, in which the aorta and the pulmonary artery have not been separated during the normal development of the fetal heart, so a single truncal artery is arising from the base of the heart. Most patients with TA present within the first weeks of life with heart failure. This anomaly is an important cause of pulmonary arterial hypertension. Corrective surgery is indicated in the first 3 months of life, to avoid the development of severe pulmonary arterial hypertension. We report the case of a 12-month-old male infant diagnosed by echocardiography with truncus arteriosus type 1 in whom, based on hemodynamic data, surgical treatment could be performed at the age of 1 year

Significance of Serum Uric Acid in Children with Pulmonary Arterial Hypertension

Introduction: Pulmonary arterial hypertension (PAH) is a complex disease with poor prognosis. Serum uric acid has been proposed as a potentially non-invasive and objective parameter for prognosis and response to therapy

Is Hypovitaminosis D a Risk Factor for Heart Failure?

Background: Several studies in recent years have shown the association between vitamin D levels and heart failure. Vitamin D deficiency is related to increased cardiovascular morbidity and mortality, with a higher risk of developing heart failure. In this systematic review, we aimed to assess recent studies that analyzed vitamin D deficiency and heart failure in adult and pediatric populations. (2) Methods: We conducted a systematic search for studies published in the following databases: PubMed and Scopus from January 2012 to October 2022. (3) Results: Most observational studies that were included found a significant association between hypovitaminosis D and heart failure. However, the beneficial role of vitamin D supplementation is still controversial due to the lack of randomized controlled trials. (4) Conclusions: Vitamin D may play an important role as a cardiovascular marker in heart failure patients. More well-designed studies are needed to investigate the relationship between vitamin D and heart failure and to determine if vitamin D supplementation could improve long-term outcomes

Association between MDR1 gene polymorphism and clinical course of pediatric pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a progressive disease with a complex pathogenesis. The polymorphism of the gene of multidrug resistance-1 (MDR1) has been associated with many diseases including PAH