3 research outputs found
Postprandial triglyceride-rich lipoproteins induce hepatic insulin resistance in HepG2 cells independently of their receptor-mediated cellular uptake
â–º The pathophysiological link between NAFLD and hepatic insulin resistance is unknown. â–º We studied the effect of postprandial lipoproteins on hepatic insulin sensitivity. â–º Postprandial lipoproteins cause liver steatosis and hepatic insulin resistance. â–º We characterize the underlying molecular mechanisms. â–º Postprandial lipoproteins are a link between NAFLD and hepatic insulin resistance