The effect of a prostaglandin E-1 derivative on the symptoms and quality of life of patients with lumbar spinal stenosis

Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18 medical institutions in our prefecture and were diagnosed with LSS-associated intermittent claudication. A second survey was performed after a parts per thousand yen6 weeks for 79 of the subjects to evaluate therapy with limaprost (an oral prostaglandin E1 derivative) or etodolac (an NSAID). Symptoms, maximum walking time, QOL, ADL items, and relationships among these variables were investigated for all 91 patients. Leg pain, leg numbness, and low back pain while walking were surveyed by use of VAS scores (0-100). Leg pain, leg numbness, and low back pain while walking (VAS a parts per thousand yen25) were present in 83.5, 62.6, and 54.9 % of the patients in the first survey, and approximately half of the patients had a maximum walking time 30 min, showing that maximum walking time affected health-related QOL. Of the 79 patients who completed the second survey, 56 had taken limaprost and 23 (control group) had received etodolac. Limaprost improved possible walking time, reduced ADL interference, and significantly increased the EQ-5D utility score, whereas no significant changes occurred in the control group. Maximum walking time was prolonged by a parts per thousand yen10 min and the EQ-5D utility value was improved by a parts per thousand yen0.1 points in significantly more patients in the limaprost group than in the control group. According to the findings of this survey, at an average of 8 weeks after administration limaprost improved symptoms, QOL, and ADL in LSS patients whereas treatment with an NSAID reduced pain but did not have any other effects.ArticleJOURNAL OF ORTHOPAEDIC SCIENCE. 18(2):208-215 (2013)journal articl

The Propagation Characteristic of DGPS Correction Data Signal at Inland Sea - Propagation Characteristic on LF/MF Band Radio Wave

User at the Inland Sea requires high position accuracy which is 5 m (2drms) or less. Therefore the position accuracy of standalone GPS is insufficiency. Consequently it needs to use DGPS for navigator sailing the Inland Sea. We executed numerical simulation of the propagation characteristic on the extended line of bridge pier at opposite side from DGPS station, and already confirmed that bit error in DGPS correction data signal occurs, and that correction data could not form by bit error. Furthermore, we carried out numerical simulation of the propagation characteristic of DGPS correction data signal received at sailing through center of the bridge, and solved receiving condition of DGPS correction data signal before and after passing through the bridge. In this paper, we executed to inspect mutually results of electric field intensity simulation for oversea and overland propagation on some sea area of the Inland Sea and measuring results of electric field intensity for DGPS correction data signal, and evaluated the possibility of abnormal propagation comprehensively