Identification and Estimation of Structural-Change Models with Misclassification

Consider a simple change-point model with a binary regressor. We examine the consistency of the change-point estimator when the regressor is subject to misclassification. It is found that the time of change can always be identified. Further, special cases where the structural parameters can also be identified are discussed. Simulation evidence is provided.

New Chinese Cinema at the HKIFF

The Hong Kong International Film Festival was one of the earliest places where new Chinese films were shown outside China. In this article, three curators involved in the selection explain how they were first received

Dynamic wind loading of H-shaped tall buildings

Fulltext in: http://www.iawe.org/Proceedings/7APCWE/M3A_5.pdfTechnical Session: M3-A High-Rise Building, no.5Dynamic wind loads on a number of H-shaped tall buildings are measured in the wind tunnel with a highfrequency force balance for all wind incidences. The aim is to investigate the size effect of the recessed cavities on the dynamic wind loading behavior of the building. Combinations of three widths and three depths of a cavity are tested. It is found that at most wind incidences, the presence of cavities on the building faces leads to little modifications to the magnitudes and behavior of mean and fluctuating overturning moment coefficients. However, reduced magnitudes of across-wind moment fluctuations are found at normal incidence and different behavior of across-wind excitation is revealed by the across-wind moment spectra. Wind torsion is noticeably modified by the presence of the recessed cavities.link_to_subscribed_fulltex

Infection after fracture osteosynthesis – Part II: Treatment

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Infection after fracture osteosynthesis – Part I: Pathogenesis, diagnosis and classification

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PTEN underexpression was associated with more aggressive tumor behaviour in hepatocellular carcinoma and PTEN suppressed cell invasion by downregulating NF-κB signaling pathway

Top Scored Posters: P-006postprintThe 3rd Annual Conference of the International Liver Cancer Association (ILCA 2009), Milan, Italy, 4-6 September 2009. In Abstract Book of ILCA 2009, 2009, p. 20, abstract no. P-00

Development of a standardized multiplex Filovirus and SARS-CoV2 antibody immunoassay

With the goal of producing multivalent recombinant subunit filovirus and SARS-CoV-2 vaccines, we develop formulations using surface glycoproteins of Ebola, Marburg and Sudan viruses or the Spike protein of the SARS-CoV-2 virus. In determining the potency of our formulations in generating an immune response in mice and non-human primates (NHP), serum antibody titers are used. Instead of using conventional antigen-binding ELISA assays for each antigen, we conduct testing by a custom multiplex immunoassay. This method uses regionally different magnetic beads coupled to purified recombinant antigens which are incubated with serum dilutions to simultaneously determine the antibody titers to the different immunizing antigens. After application of a secondary, fluorescently labeled antibody, values are normally shown as median fluorescent intensity or MFI. By converting the MFI to an actual concentration, samples from different studies can more easily be compared. For this, standard curves using purified antigen-specific immunoglobulin G (IgG) to the three filovirus GP’s or SARS-CoV2 spike protein are established with each assay. Standards were prepared passing high-titered mouse or NHP sera over a protein G column to isolate IgG, then purified further using affinity-chromatography columns with individual filovirus GP’s or SARS-CoV-2 spike protein to select for antigen-specificity. The standards are quantified and curves are generated which will be run with each set of serum samples. Please click Download on the upper right corner to see the full abstract