92,793 research outputs found
Thinning and thickening in active microrheology
When pulling a probe particle in a many-particle system with fixed velocity,
the probe's effective friction, defined as average pulling force over its
velocity, , first keeps constant (linear
response), then decreases (thinning) and finally increases (thickening). We
propose a three-time-scales picture (TTSP) to unify thinning and thickening
behaviour. The points of the TTSP are that there are three distinct time scales
of bath particles: diffusion, damping, and single probe-bath (P-B) collision;
the dominating time scales, which are controlled by the pulling velocity,
determine the behaviour of the probe's friction. We confirm the TTSP by
Langevin dynamics simulation. Microscopically, we find that for computing the
effective friction, Maxwellian distribution of bath particles' velocities works
in low Reynolds number (Re) but fails in high Re. It can be understood based on
the microscopic mechanism of thickening obtained in the limit. Based on
the TTSP, we explain different thinning and thickening observations in some
earlier literature
A Unified Quantitative Model of Vision and Audition
We have put forwards a unified quantitative framework of vision and audition,
based on existing data and theories. According to this model, the retina is a
feedforward network self-adaptive to inputs in a specific period. After fully
grown, cells become specialized detectors based on statistics of stimulus
history. This model has provided explanations for perception mechanisms of
colour, shape, depth and motion. Moreover, based on this ground we have put
forwards a bold conjecture that single ear can detect sound direction. This is
complementary to existing theories and has provided better explanations for
sound localization.Comment: 7 pages, 3 figure
Motor Learning Mechanism on the Neuron Scale
Based on existing data, we wish to put forward a biological model of motor
system on the neuron scale. Then we indicate its implications in statistics and
learning. Specifically, neuron firing frequency and synaptic strength are
probability estimates in essence. And the lateral inhibition also has
statistical implications. From the standpoint of learning, dendritic
competition through retrograde messengers is the foundation of conditional
reflex and grandmother cell coding. And they are the kernel mechanisms of motor
learning and sensory motor integration respectively. Finally, we compare motor
system with sensory system. In short, we would like to bridge the gap between
molecule evidences and computational models.Comment: 8 pages, 4 figure
Guide Positioning Sequencing identifies aberrant DNA methylation patterns that alter cell identity and tumor-immune surveillance networks
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