Detection of genuinely entangled and non-separable nn-partite quantum states

We investigate the detection of entanglement in $n$-partite quantum states. We obtain practical separability criteria to identify genuinely entangled and non-separable mixed quantum states. No numerical optimization or eigenvalue evaluation is needed, and our criteria can be evaluated by simple computations involving components of the density matrix. We provide examples in which our criteria perform better than all known separability criteria. Specifically, we are able to detect genuine $n$-partite entanglement which has previously not been identified. In addition, our criteria can be used in today's experiment.Comment: 8 pages, one figur

A stochastic and dynamical view of pluripotency in mouse embryonic stem cells

Pluripotent embryonic stem cells are of paramount importance for biomedical research thanks to their innate ability for self-renewal and differentiation into all major cell lines. The fateful decision to exit or remain in the pluripotent state is regulated by complex genetic regulatory network. Latest advances in transcriptomics have made it possible to infer basic topologies of pluripotency governing networks. The inferred network topologies, however, only encode boolean information while remaining silent about the roles of dynamics and molecular noise in gene expression. These features are widely considered essential for functional decision making. Herein we developed a framework for extending the boolean level networks into models accounting for individual genetic switches and promoter architecture which allows mechanistic interrogation of the roles of molecular noise, external signaling, and network topology. We demonstrate the pluripotent state of the network to be a broad attractor which is robust to variations of gene expression. Dynamics of exiting the pluripotent state, on the other hand, is significantly influenced by the molecular noise originating from genetic switching events which makes cells more responsive to extracellular signals. Lastly we show that steady state probability landscape can be significantly remodeled by global gene switching rates alone which can be taken as a proxy for how global epigenetic modifications exert control over stability of pluripotent states.Comment: 11 pages, 7 figure

Fabrication of a focusing soft X-ray collector payload

A large area X-ray focusing collector with arc minute resolution and a position sensitive detector capable of operating in the soft X-ray region was developed for use on sounding rockets in studying stellar X-ray sources. The focusing payload consists of the following components, which are described: (1) a crossed paraboloid mirror assembly; (2) an aspect camera and star tracker; (3) a focal plane assembly containing an imaging proportional counter and its preamplifiers, high voltage power supplies and gas system; (4) a fiducial system; and (5) housekeeping, data handling, instrumentation and telemetry electronics. The design, tests, and operation are described

Growth and characteristics of type-II InAs/GaSb superlattice-based detectors

We report on growth and device performance of infrared photodetectors based on type II InAs/Ga(In)Sb strain layer superlattices (SLs) using the complementary barrier infrared detector (CBIRD) design. The unipolar barriers on either side of the absorber in the CBIRD design in combination with the type-II InAs/GaSb superlattice material system are expected to outperform traditional III-V LWIR imaging technologies and offer significant advantages over the conventional II-VI material based FPAs. The innovative design of CBIRDS, low defect density material growth, and robust fabrication processes have resulted in the development of high performance long wave infrared (LWIR) focal plane arrays at JPL

The scalars from the topcolor scenario and the spin correlations of the top pair production at the LHC

The topcolor scenario predicts the existences of some new scalars. In this paper, we consider the contributions of these new particles to the observables, which are related to the top quark pair ($t\bar{t}$) production at the LHC. It is found that these new particles can generate significant corrections to the $t\bar{t}$ production cross section and the $t\bar{t}$ spin correlations.Comment: 23 pages, 4 figures; discussions and references added; agrees with published versio

Goal-Focused Emotion-Regulation Therapy (GET) for young adult survivors of testicular cancer: a pilot randomized controlled trial of a biobehavioral intervention protocol.

BackgroundTesticular cancer diagnosis and treatment, especially given its threat to sexuality and reproductive health, can be distressing in the formative period of young adulthood and the majority of young survivors experience impairing, distressing, and modifiable adverse outcomes that can persist long after medical treatment. These include psychological distress, impairment in pursuit of life goals, persistent physical side effects, elevated risk of secondary malignancies and chronic illness, and biobehavioral burden (e.g., enhanced inflammation, dysregulated diurnal stress hormones). However, few targeted interventions exist to assist young survivors in renegotiating life goals and regulating cancer-related emotions, and none focus on reducing the burden of morbidity via biobehavioral mechanisms. This paper describes the methodology of a randomized controlled biobehavioral trial designed to investigate the feasibility and preliminary impact of a novel intervention, Goal-focused Emotion-Regulation Therapy (GET), aimed at improving distress symptoms, emotion regulation, goal navigation skills, and stress-sensitive biomarkers in young adult testicular cancer patients.MethodsParticipants will be randomized to receive six sessions of GET or Individual Supportive Therapy (ISP) delivered over 8 weeks. In addition to indicators of intervention feasibility, we will measure primary (depressive and anxiety symptoms) and secondary (emotion regulation and goal navigation skills, career confusion) psychological outcomes prior to (T0), immediately after (T1), and 12 weeks after (T2) intervention. Additionally, identified biomarkers will be measured at baseline and at T2.DiscussionGET may have the potential to improve self-regulation across biobehavioral domains, improve overall cancer adjustment, and address the need for targeted supportive care interventions for young adult cancer survivors.Trial registrationClinicaltrials.gov, NCT04150848. Registered on 28 October 2019

WMAP constraints on the Intra-Cluster Medium

We devise a Monte-Carlo based, optimized filter match method to extract the thermal Sunyaev-Zel'dovich (SZ) signature of a catalog of 116 low-redshift X-ray clusters from the first year data release of the Wilkinson Microwave Anisotropy Probe (WMAP). We detect an over-all amplitude for the SZ signal at the ~ 8-sigma level, yielding a combined constraint of f_{gas}h = 0.08 +/- 0.01 (ran) +/- 0.01 (sys) on the gas mass fraction of the Intra-Cluster Medium. We also compile X-ray estimated gas fractions from the literature for our sample, and find that they are consistent with the SZ estimates at the 2-sigma level, while both show an increasing trend with X-ray temperature. Nevertheless, our SZ estimated gas fraction is 30-40% smaller than the concordance LCDM cosmic average. We also express our observations in terms of the SZ flux-temperature relation, and compare it with other observations, as well as numerical studies. Based on its spectral and spatial signature, we can also extract the microwave point source signal of the clusters at the 3-sigma level, which puts the average microwave luminosity (at ~ 41 GHz) of bright cluster members (M_K < -21) at (2.4 +/- 0.8) x 10^{27} h^{-2} erg/s/Hz. Furthermore, we can constrain the average dark matter halo concentration parameter to c_{vir}=3.4+0.6-0.9, for clusters with T_x > 5 kev. Our work serves as an example for how correlation of SZ surveys with cluster surveys in other frequencies can significantly increase our physical understanding of the intra-cluster medium.Comment: 34 pages, 6 ps figures, Extended discussion of theoretical uncertainties, radio sources, and future prospects, Accepted for Publication in Ap