Lactate Removal from the Blood of Trained Distance Runners Following Strenuous Intermittent Exercise

The purpose of the study was to investigate the rate of lactate removal from the blood of trained distance runners, during recovery from maximal intermittent exercise. Five well trained male subjects (mean VO2 max of 69.79 ml/kg/min) were selected for the study. Four of the subjects were members of the 1975 Intercollegiate Cross Country team and one was a member of the 1975 Intercollegiate Soccer team at Eastern Illinois University. Each subject received an orientation to the treadmill and a maximum oxygen consumption test prior to the actual test procedure. The test procedure consisted of three separate warm-down periods following maximal intermittent exercise. The three warm-down periods were 30 minutes in duration and consisted of sitting, walking at four miles per hour, and jogging at eight miles per hour. Blood samples were drawn from an arm vein of the subject five, 15, and 30 minutes following exercise and were analyzed for lactate. A Friedman two-way analysis of variance by ranks was used to test whether there were any significant differences between the blood lactate concentrations of the different warm-down procedures. It was concluded that the 30 minute, eight mile per hour jog was a better warm-down procedure than the 30 minute, four mile per hour walk for removal of lactate from the blood of trained distance runners. Sitting for 30 minutes was the least effective method

Exercise training results in lower amyloid plaque load and greater cognitive function in an intensity dependent manner in the Tg2576 mouse model of Alzheimer\u27s disease

Three months of exercise training (ET) decreases soluble A

The IDENTIFY study: the investigation and detection of urological neoplasia in patients referred with suspected urinary tract cancer - a multicentre observational study

Objective To evaluate the contemporary prevalence of urinary tract cancer (bladder cancer, upper tract urothelial cancer [UTUC] and renal cancer) in patients referred to secondary care with haematuria, adjusted for established patient risk markers and geographical variation. Patients and Methods This was an international multicentre prospective observational study. We included patients aged ≥16 years, referred to secondary care with suspected urinary tract cancer. Patients with a known or previous urological malignancy were excluded. We estimated the prevalence of bladder cancer, UTUC, renal cancer and prostate cancer; stratified by age, type of haematuria, sex, and smoking. We used a multivariable mixed-effects logistic regression to adjust cancer prevalence for age, type of haematuria, sex, smoking, hospitals, and countries. Results Of the 11 059 patients assessed for eligibility, 10 896 were included from 110 hospitals across 26 countries. The overall adjusted cancer prevalence (n = 2257) was 28.2% (95% confidence interval [CI] 22.3–34.1), bladder cancer (n = 1951) 24.7% (95% CI 19.1–30.2), UTUC (n = 128) 1.14% (95% CI 0.77–1.52), renal cancer (n = 107) 1.05% (95% CI 0.80–1.29), and prostate cancer (n = 124) 1.75% (95% CI 1.32–2.18). The odds ratios for patient risk markers in the model for all cancers were: age 1.04 (95% CI 1.03–1.05; P < 0.001), visible haematuria 3.47 (95% CI 2.90–4.15; P < 0.001), male sex 1.30 (95% CI 1.14–1.50; P < 0.001), and smoking 2.70 (95% CI 2.30–3.18; P < 0.001). Conclusions A better understanding of cancer prevalence across an international population is required to inform clinical guidelines. We are the first to report urinary tract cancer prevalence across an international population in patients referred to secondary care, adjusted for patient risk markers and geographical variation. Bladder cancer was the most prevalent disease. Visible haematuria was the strongest predictor for urinary tract cancer

Lactate Removal from the Blood of Trained Distance Runners Following Strenuous Intermittent Exercise

The purpose of the study was to investigate the rate of lactate removal from the blood of trained distance runners, during recovery from maximal intermittent exercise. Five well trained male subjects (mean VO2 max of 69.79 ml/kg/min) were selected for the study. Four of the subjects were members of the 1975 Intercollegiate Cross Country team and one was a member of the 1975 Intercollegiate Soccer team at Eastern Illinois University. Each subject received an orientation to the treadmill and a maximum oxygen consumption test prior to the actual test procedure. The test procedure consisted of three separate warm-down periods following maximal intermittent exercise. The three warm-down periods were 30 minutes in duration and consisted of sitting, walking at four miles per hour, and jogging at eight miles per hour. Blood samples were drawn from an arm vein of the subject five, 15, and 30 minutes following exercise and were analyzed for lactate. A Friedman two-way analysis of variance by ranks was used to test whether there were any significant differences between the blood lactate concentrations of the different warm-down procedures. It was concluded that the 30 minute, eight mile per hour jog was a better warm-down procedure than the 30 minute, four mile per hour walk for removal of lactate from the blood of trained distance runners. Sitting for 30 minutes was the least effective method

Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer’s Disease

Three months of exercise training (ET) decreases soluble A&beta;40 and A&beta;42 levels in an intensity dependent manner early in life in Tg2576 mice (Moore et al., 2016). Here, we examined the effects of 12 months of low- and high- intensity exercise training on cognitive function and amyloid plaque load in the cortex and hippocampus of 15-month-old Tg2576 mice. Low- (LOW) and high- (HI) intensity ET animals ran at speeds of 15 m/min on a level treadmill and 32 m/min at a 10% grade, respectively, for 60 min/day, five days/week, from 3 to 15 months of age. Sedentary mice (SED) were placed on a level, non-moving, treadmill for the same duration. ET mice demonstrated a significantly lower amyloid plaque load in the cortex and hippocampus that was intensity dependent. Improvement in cognitive function, assessed by Morris Water Maze and Novel Object Recognition tests, was greater in the HI group compared to the LOW and SED groups. LOW mice performed better in the initial latency to the platform location during the probe trial of the Morris Water Maze (MWM) test than SED, but not in any other aspect of MWM or the Novel Object Recognition test. The results of this study indicate that exercise training decreases amyloid plaque load in an intensity dependent manner and that high-intensity exercise training improves cognitive function relative to SED mice, but the intensity of the LOW group was below the threshold to demonstrate robust improvement in cognitive function in Tg2576 mice

Interactions between stress and physical activity on Alzheimer's disease pathology

Physical activity and stress are both environmental modifiers of Alzheimer's disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies among findings remain. Studies using forced exercise may increase stress and mitigate some of the benefit of physical activity in AD models, while voluntary exercise regimens may not achieve optimal intensity to provide robust benefit. We evaluated the findings of studies of voluntary and forced exercise regimens in AD mouse models to determine the influence of stress, or the intensity of exercise needed to outweigh the negative effects of stress on AD measures. In addition, we show that chronic physical activity in a mouse model of AD can prevent the effects of acute restraint stress on Aβ levels in the hippocampus. Stress and physical activity have many overlapping and divergent effects on the body and some of the possible mechanisms through which physical activity may protect against stress-induced risk factors for AD are discussed. While the physiological effects of acute stress and acute exercise overlap, chronic effects of physical activity appear to directly oppose the effects of chronic stress on risk factors for AD. Further study is needed to identify optimal parameters for intensity, duration and frequency of physical activity to counterbalance effects of stress on the development and progression of AD. Keywords: Alzheimer's disease, Amyloid, Stress, Exercise, Physical activit

Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer\u27s disease

We examined the effects of voluntary (16 weeks of wheel running) and forced (16 weeks of treadmill running) exercise on memory-related behavior, hippocampal volume, thioflavine-stained plaque number, and soluble Aβ levels in brain tissue in the Tg2576 mouse model of Alzheimer\u27s disease (AD). Voluntary running animals spent more time investigating a novel object in a recognition memory paradigm than all other groups. Also, voluntary running animals showed fewer thioflavine S stained plaques than all other groups, whereas forced running animals showed an intermediate number of plaques between voluntary running and sedentary animals. Both voluntary and forced running animals had larger hippocampal volumes than sedentary animals. However, levels of soluble Aβ-40 or Aβ-42 did not significantly differ among groups. The results indicate that voluntary exercise may be superior to forced exercise for reducing certain aspects of AD-like deficits — i.e., plaque deposition and memory impairment, in a mouse model of AD

Interactions Between Stress and Physical Activity on Alzheimer\u27s Disease Pathology

Physical activity and stress are both environmental modifiers of Alzheimer\u27s disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies among findings remain. Studies using forced exercise may increase stress and mitigate some of the benefit of physical activity in AD models, while voluntary exercise regimens may not achieve optimal intensity to provide robust benefit. We evaluated the findings of studies of voluntary and forced exercise regimens in AD mouse models to determine the influence of stress, or the intensity of exercise needed to outweigh the negative effects of stress on AD measures. In addition, we show that chronic physical activity in a mouse model of AD can prevent the effects of acute restraint stress on Aβ levels in the hippocampus. Stress and physical activity have many overlapping and divergent effects on the body and some of the possible mechanisms through which physical activity may protect against stress-induced risk factors for AD are discussed. While the physiological effects of acute stress and acute exercise overlap, chronic effects of physical activity appear to directly oppose the effects of chronic stress on risk factors for AD. Further study is needed to identify optimal parameters for intensity, duration and frequency of physical activity to counterbalance effects of stress on the development and progression of AD