Characterization of mild whole-body hyperthermia protocols using human breast, ovarian, and colon tumors grown in severe combined immunodeficient mice.

OBJECTIVE: We have shown that one treatment of fever-like whole body hyperthermia (WBH) on mice bearing human breast tumors results in a tumor growth delay. Our goal was to repeat this study in mice bearing human ovarian or colon tumors. We further evaluated this WBH protocol by performing multiple and interrupted WBH treatments. METHODS: Human tumors were grown in severe combined immunodeficient (SCID) mice. For WBH, core body temperatures were maintained at 39.8+/-0.2 degrees C for 6-8 hours. Multiple treatments were given 6-7 days apart. Interrupted WBH consisted of three 2-hour heatings, 15 minutes apart. Tumor growth time (TGT) was the number of days to grow 1.5 or 2 times in volume. RESULTS: For WBH-treated ovarian tumors, TGT was 12+/-1.2d, compared with 5.0+/-0.1d for untreated mice (P < 0.05). For colon tumors with one WBH treatment TGT was 4.4+/-1.1d. Two and three treatments had TGTs of 9+/-2.3d and 8+/-1.6d. For the untreated tumors, TGT was 2+/-0.7d (P < 0.01 for one, two, and three treatments). Histological examination indicated that one and two treatments were associated with cellular damage within the tumors. With a slower growing colon tumor, the TGT was 24+/-3.3d with three WBH treatments, compared with 14+/-1.8d for controls (P < 0.01). The TGT of breast tumors treated with interrupted WBH was not significantly different than the noninterrupted, with TGT of 7.3+/-0.8d and 6.2+/-1.0d, respectively. CONCLUSIONS: These data illustrate that WBH causes a tumor growth delay in mice bearing human ovarian and colon tumors. This response is enhanced with a second treatment of WBH. Interrupted and noninterrupted WBH give comparable anti-tumor results. We will continue to evaluate WBH in various animal models to optimize its potential for clinical administration and maximize the anti-tumor response

Creating A Creative State of Mind: Promoting Creativity Through Proactive Vitality Management and Mindfulness

Most research on employee creativity has been focused on relatively distal antecedents, such as personality or job characteristics, which has resulted in top-down organizational approaches to promote employee creativity. However, such approaches overlook the self-regulating potential of employees and may not explain intraindividual fluctuations in creativity. In the present research, we build on proactive motivation theory to examine how employees may promote their own creativity on a daily basis through the use of proactive vitality management (PVM). To better understand the PVM-creativity link, we zoom in on this process by examining the role of mindfulness as an underlying mechanism. In two daily diary studies, employees from the United States (N = 133 persons, n = 521 data points) and the creative industry in Germany (N = 62 persons, n = 232 data points) reported on their use of PVM and states of mindfulness for five consecutive workdays. Additionally, participants completed a daily creativity test (brainstorming task) in Study 1, whereas supervisors rated participants' daily creative work performance in Study 2. In both studies, multilevel analyses showed that daily PVM was positively related to creative performance through daily mindfulness, supporting our hypotheses. These replicated findings suggest that individuals may bring themselves in a cognitive, creative state of mind on a daily basis, emphasizing the importance of proactive behavior in the creative process

Novel matching lens and spherical ionizer for a cesium sputter ion source

The beam optics of a multi-sample sputter ion source, based on the NECMCSNICS, has been modified to accommodate cathode voltages higher than 5 kV and dispenses with the nominal extractor. The cathode voltage in Cs sputter sources plays the role of the classical extractor accomplishing the acceleration of beam particles from eV to keV energy, minimizing space charge effects and interactions between the beam and residual gas. The higher the cathode voltage, the smaller are these contributions to the emittance growth. The higher cathode voltage also raises the Child’s law limit on the Cs current resulting in substantially increased output. The incidental focusing role of the extractor is reallocated to a deceleration Einzel lens and the velocity change needed to match to the pre-acceleration tube goes to a new electrode at the tube entrance. All electrodes are large enough to ensure that the beam fills less than 30% of the aperture to minimize aberrations. The improvements are applicable to sputter sources generally

Determination of total I and 129I concentrations in freshwater of Argentina

Total iodine and129-iodine in rivers and lakes of Argentina were measured by means of inductively coupled plasma mass spectrometry and accelerator mass spectrometry respectively. The obtained isotopic ratios, higher than the natural level, are explained

Isospin-1/2 DπD\pi scattering and the lightest D0∗D_0^\ast resonance from lattice QCD

Isospin-1/2 $D\pi$ scattering amplitudes are computed using lattice QCD, working in a single volume of approximately $(3.6\; \mathrm{fm})^3$ and with a light quark mass corresponding to $m_\pi\approx239$ MeV. The spectrum of the elastic $D\pi$ energy region is computed yielding 20 energy levels. Using the L\"uscher finite-volume quantisation condition these energies are translated into constraints on the infinite volume scattering amplitudes. For the first time, we find a complex $D_0^\ast$ resonance pole from lattice QCD, strongly coupled to the $S$-wave $D\pi$ channel, with a mass $m\approx 2200$ MeV and a width $\Gamma\approx400$ MeV. Combined with earlier work investigating the $D_{s0}^\ast$, and $D_0^\ast$ with heavier light quarks, similar couplings between each of these scalar states and their relevant meson-meson scattering channels are determined. The mass of the $D_0^\ast$ is consistently found well below that of the $D_{s0}^\ast$, in contrast to the currently reported experimental result.Comment: 39 pages, 13 figure

Triggers of defensive medical behaviours: A cross-sectional study among physicians in the Netherlands

Objectives This study investigated whether the attitudes of physicians towards justified and unjustified litigation, and their perception of patient pressure in demanding care, influence their use of defensive medical behaviours. Design Cross-sectional survey using exploratory factor analysis was conducted to determine litigation attitude and perceived patient pressure factors. Regression analyses were used to regress these factors on to the ordering of extra tests or procedures (defensive assurance behaviour) or the avoidance of high-risk patients or procedures (defensive avoidance behaviour). Setting Data were collected from eight Dutch hospitals. Participants Respondents were 160 physicians and 54 residents (response rate 25%) of the hospital departments of (1) anaesthesiology, (2) colon, stomach and liver diseases, (3) gynaecology, (4) internal medicine, (5) neurology and (6) surgery. Primary outcome measures Respondents' application of defensive assurance and avoidance behaviours. Results € Disapproval of justified litigation' and € Concerns about unjustified litigation' were positively related to both assurance (β=0.21, p<0.01, and β=0.28, p<0.001, respectively) and avoidance (β=0.16, p<0.05, and β=0.18, p<0.05, respectively) behaviours. € Self-blame for justified litigation' was not significantly related to both defensive behaviours. Perceived patient pressures to refer (β=0.18, p<0.05) and to prescribe medicine (β=0.23, p<0.01) had direct positive relationships with assurance behaviour, whereas perceived patient pressure to prescribe medicine was also positively related to avoidance behaviour (β=0.14, p<0.05). No difference was found between physicians and residents in their defensive medical behaviour. Conclusions Physicians adopted more defensive medical behaviours if they had stronger thoughts and emotions towards (un)justified litigation. Further, physicians should be aware that perceived patient pressure for care can lead to them adopting defensive behaviours that negatively affects the quality and safety of patient care

Proactive vitality management in the work context

In the present research, we use proactivity literature and studies on energy at work to argue that individuals may proactively manage their vitality (i.e., physical and mental energy) to promote optimal functioning at work. We develop and validate a scale to measure proactive vitality management (PVM), and explore the nomological network. We conducted a five-day diary study (N = 133; 521 days), a survey study (N = 813) and a cross-sectional study measuring daily PVM (N = 246) among working individuals from various occupational sectors. The results show that PVM can be reliably measured with eight items that load on one overall factor, both on general and daily level. Furthermore, daily PVM was moderately but positively related to the use of work-related strategies and micro-breaks. Moreover, PVM related positively to relevant personal characteristics (i.e., proactive personality and self-insight) and showed moderate but positive relationships with job crafting and relaxation (convergent validity). PVM was unrelated to psychological detachment and decreasing hindering demands (discriminant validity). Finally, PVM was positively related to well-being, in-role work performance, creative work performance and performance on the Remote Associates Test (criterion validity). We conclude that employees may promote their own work performance through the use of PVM

Proactive vitality management and creative work performance: The role of self-insight and social support

Integrating proactivity and creativity literatures, we argue that people can perform more creatively at work w

Isospin-1/2 Dπ scattering and the lightest D 0 ∗ resonance from lattice QCD

Abstract: Isospin-1/2 Dπ scattering amplitudes are computed using lattice QCD, working in a single volume of approximately (3.6 fm)3 and with a light quark mass corresponding to mπ ≈ 239 MeV. The spectrum of the elastic Dπ energy region is computed yielding 20 energy levels. Using the Lüscher finite-volume quantisation condition, these energies are translated into constraints on the infinite-volume scattering amplitudes and hence enable us to map out the energy dependence of elastic Dπ scattering. By analytically continuing a range of scattering amplitudes, a D0∗ resonance pole is consistently found strongly coupled to the S-wave Dπ channel, with a mass m ≈ 2200 MeV and a width Γ ≈ 400 MeV. Combined with earlier work investigating the Ds0∗, and D0∗ with heavier light quarks, similar couplings between each of these scalar states and their relevant meson-meson scattering channels are determined. The mass of the D0∗ is consistently found well below that of the Ds0∗, in contrast to the currently reported experimental result