13 research outputs found
向精神薬服用患者の突然死症例におけるカリウムイオンチャネルに関する分子生物学的解析:QT延長症候群関連遺伝子の多型が危険因子となり得るか?
Psychotropic drugs can pose the risk of acquired long QT syndrome (LQTS). Unexpected autopsy-negative sudden death in patients taking psychotropic drugs may be associated with prolonged QT intervals and life-threatening arrhythmias. We analyzed genes that encode for cardiac ion channels and potentially associated with LQTS, examining specifically the potassium channel genes KCNQ1 and KCNH2 in 10 cases of sudden death involving patients administered psychotropic medication in which autopsy findings identified no clear cause of death. We amplified and sequenced all exons of KCNQ1 and KCNH2, identifying G643S, missense polymorphism in KCNQ1, in 6 of the 10 cases. A study analysis indicated that only 11% of 381 healthy Japanese individuals carry this polymorphism. Reports of previous functional analyses indicate that the G643S polymorphism in the KCNQ1 potassium channel protein causes mild IKs channel dysfunction. Our present study suggests that administering psychotropic drug therapy to individuals carrying the G643S polymorphism may heighten the risk of prolonged QT intervals and life-threatening arrhythmias. Thus, screening for the G643S polymorphism before prescribing psychotropic drugs may help reduce the risk of unexpected sudden death2013博士(歯学)松本歯科大
Determinants of torsades de pointes in older patients with drug-associated long QT syndrome: a case-control study
Experimental Intracameral Injection of Vancomycin Microparticles in Rabbits
Journal of Ecohydrology & Hydrobiology, 2017; 17 : 33–45The values of watershed services from watersheds has for many years been neglected,
underestimated and not factored in land use decisions for sustainable management.
Sustainable management of watersheds and environmental friendly economic activities
are vital for sustained water flow, steady supply of ecosystem services for societal needs
and enhancement of aquatic vegetation and animal species. The problem of the failure to
capture actual values of ecosystem services from watersheds and incorporate them in the
national income accounting is profound in developing countries which are characterized
with constrained budget for financing conservation programs. To resolve this problem
attention has moved to market based instruments such as payment for watershed services
(PWS). However, the approach to elicit the necessary information for PWS to kick off is still
lacking. Furthermore, Ecohydrology, defined as an integrative sustainability science using
the interactions between hydrology, biota and natural processes as management tools to
reinforce ecosystem services on a broad range of landscapes (Zalewski, 2015) is a basis for
the development and application of market-based approaches in watershed conservation.
This study investigated small holder farmers’ willingness to pay (WTP) for watershed
services in Pangani River Basin. A contingent valuation method was employed to elicit the
willingness to pay for watershed conservation. A probit model was used to determine
respondents’ response to WTP and factors conditioning the maximum amount they are
WTP. Findings indicates that majority of respondents are willing to pay for watershed
services. Similarly, result reveals that marital status, household size and distance from the
water source positively influence smallholder farmers’ WTP and the maximum amount to
be paid. Equally important occupation, household size, income from irrigation, and amount
paid for irrigation were found to negatively influencing smallholder farmers’ WTP. The
result also revealed that education level, total land size and yield from irrigated farm plot
positively influence smallholder farmers’ WTP. These results therefore, indicate that
establishment of PWS is feasible