Sex differences in the associations between L-arginine pathway metabolites, skeletal muscle mass and function, and their responses to resistance exercise, in old age

This work was supported by the Biotechnology and Biological Sciences Research Council (BB/J015911/1) and was registered at clinicaltrials.gov (ClinicalTrials. gov Identifier: NCT02843009). Supplementary email included with articlePeer reviewedPostprin

Lessons from France: The Cardiovascular Prevention Clinic in the La Pitié-Salpêtrière Hospital in Paris

Cardiovascular disease is the principal cause of morbidity and mortality in the Netherlands. In this background, various initiatives have been launched to reduce the frequency of cardiovascular disease. One of those is the creation of clinical units with a special focus on prevention of cardiovascular disease. Hitherto, the prevention programmes of these clinics have been heterogeneous and therefore difficult to compare with respect to results. Similar developments in creating clinical initiatives concerning prevention of cardiovascular disease are found across Europe. With this in mind, lessons could be learned from each other’s experiences. In our contribution, we would like to present the Cardiovascular Prevention Clinic in the Pitié- Salpêtrière Hospital in Paris, France, as an interesting example of a well-acknowledged cardiovascular prevention clinic that combines both daily clinical care and cardiovascular science. (Neth Heart J 2007;15:22-6.

Lessons from france: the cardiovascular prevention clinic in the la pitie-salpetriere hospital in paris.

Item does not contain fulltextCardiovascular disease is the principal cause of morbidity and mortality in the Netherlands. In this background, various initiatives have been launched to reduce the frequency of cardiovascular disease. One of those is the creation of clinical units with a special focus on prevention of cardiovascular disease. Hitherto, the prevention programmes of these clinics have been heterogeneous and therefore difficult to compare with respect to results. Similar developments in creating clinical initiatives concerning prevention of cardiovascular disease are found across Europe. With this in mind, lessons could be learned from each other's experiences. In our contribution, we would like to present the Cardiovascular Prevention Clinic in the Pitie- Salpetriere Hospital in Paris, France, as an interesting example of a well-acknowledged cardiovascular prevention clinic that combines both daily clinical care and cardiovascular science. (Neth Heart J 2007;15:22-6.)

Initial Experience Treating Lung Tumors with the CyberKnife

Stereotactic body radiosurgery (SBRS) of lung tumors with the CyberKnife® (Accuray Incorporated, Sunnyvale, CA) achieves excellent rates of local disease control with limited toxicity to surrounding tissues. We retrospectively reviewed treatments and outcomes for 90 patients with 109 lung lesions treated at the CyberKnife Center of Miami between March 2004 and September 2006. This monotherapy review included 49 patients with 53 primary lung cancers, 27 patients with 42 pulmonary metastases, 6 patients with external beam failure and 8 patients treated by SBRS as a boost following or before conventionally fractionated radiotherapy (3DCRT or IMRT). In the primary tumor category, 43 patients remain alive. Thirty-two have been followed 1 to 25 months (median = 11.5 months). Fortynine percent (21/43) of them have had a complete radiographic response and have been followed for a median of 18.5 months. Another 8 have evidence of at least a partial radiographic response. There have been 5 failures (5/43) within the PTV, for a local recurrence rate of 11%. Of the total 109 treated lesions, 97/109 (89%) showed radiographic evidence of at least a partial response to treatment. Six of the failures were in lesions 100 cc. All of the patients tolerated SBRS well with fatigue as the main toxicity. Two patients required hospitalization for Grade III radiation pneumonitis. We conclude that the delivery of precisely targeted, high dose, hypofractionated irradiation to lung tumors with the CyberKnife is well tolerated and has outcomes that are comparable with published results for other methods of SBRS