1 research outputs found
Peanut thresholds in peanutâallergic children are related to dietary composition
Abstract Background There is no clear explanation for the large variation in threshold levels among peanutâallergic children. We hypothesized that diet composition can partly explain this variation in thresholds, as nutrients and foods influence the intestinal barrier function and microbiota. Aim to explore the relationship between the threshold levels for peanut and nutritional intake and gut microbial composition in peanutâallergic children. Methods In this explorative crossâsectional study the cumulative threshold levels for peanut were determined by oral food challenge tests. Data on nutrients and foods consumed were obtained from 3âday food diaries. Microbial composition of faeces and saliva were determined by molecular microbiota detection technique. Multivariable linear regression analysis and multiple logistic regression were used to explore the associations, adjusted for energy and senitization. Results Sixtyâfive children were included, of whom 32 (49%) (median age 50 months, IQR 28.0â96.5) had a positive oral food challenge. Significant positive associations were found between the intake of total carbohydrates, vitamin A and cumulative threshold levels for peanut, while significant negative associations were found for longâchain polyunsaturated fatty acids, linoleic acid and omegaâ6 fatty acids. No associations were found between threshold levels and microbial composition of faeces and saliva. However, a significant higher abundance of Proteobacteria and Bacteroidetes in saliva (pâ=â0.011 and 0.04, respectively) and of Proteobacteria in faeces (pâ=â0.003) were found in children with a positive peanut challenge compared to children with a negative peanut challenge. Conclusion As a novel concept, this study showed that dietary composition is related to threshold levels for peanut