Human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50 are admixtures of the human colon carcinoma cell line HCT 116

In two recently described human oesophageal adenocarcinoma cell lines JROECL 47 and JROECL 50, derived from one tumour, we detected identical E-cadherin and β-catenin gene mutations as in colon carcinoma cell line HCT 116. We demonstrate by HLA-typing, mutation analysis and microsatellite analysis that cell lines JROECL 47 and JROECL 50 are admixtures of the human colon adenocarcinoma cell line HCT 116. © 2000 Cancer Research Campaig

A New Probe of the Molecular Gas in Galaxies: Application to M101

Recent studies of nearby spiral galaxies suggest that photodissociation regions (PDRs) are capable of producing much of the observed HI in galaxy disks. In that case, measurements of the HI column density and the far-ultraviolet (FUV) photon flux provide a new probe of the volume density of the local underlying H_2. We develop the method and apply it to the giant Scd spiral M101 (NGC 5457). We find that, after correction for the best-estimate gradient of metallicity in the ISM of M101 and for the extinction of the ultraviolet emission, molecular gas with a narrow range of density from 30-1000 cm^-3 is found near star- forming regions at all radii in the disk of M101 out to a distance of 12' (approximately 26 kpc), close to the photometric limit of R_25 = 13.5'. In this picture, the ISM is virtually all molecular in the inner parts of M101. The strong decrease of the HI column density in the inner disk of the galaxy at R_G < 10 kpc is a consequence of a strong increase in the dust-to-gas ratio there, resulting in an increase of the H_2 formation rate on grains and a corresponding disappearance of hydrogen in its atomic form.Comment: accepted for publication in The Astrophysical Journal (1 August 2000); 29 pages including 20 figures (7 gif); AAS LaTex; contact authors for full resolution versions of gif figure

Spectral evidence for a powerful compact jet from XTE J1118+480

We present observations of the X-ray transient XTE J1118+480 during its Low/Hard X-ray state outburst in 2000, at radio and sub-millimetre wavelengths with the VLA, Ryle Telescope, MERLIN and JCMT. The high-resolution MERLIN observations reveal all the radio emission (at 5 GHz) to come from a compact core with physical dimensions smaller than 65*d(kpc) AU. The combined radio data reveal a persistent and inverted radio spectrum, with spectral index \~+0.5. The source is also detected at 350 GHz, on an extrapolation of the radio spectrum. Flat or inverted radio spectra are now known to be typical of the Low/Hard X-ray state, and are believed to arise in synchrotron emission from a partially self-absorbed jet. Comparison of the radio and sub-millimetre data with reported near-infrared observations suggest that the synchrotron emission from the jet extends to the near-infrared, or possibly even optical regimes. In this case the ratio of jet power to total X-ray luminosity is likely to be P_J/L_X >> 0.01, depending on the radiative efficiency and relativistic Doppler factor of the jet. Based on these arguments we conclude that during the period of our observations XTE J1118+480 was producing a powerful outflow which extracted a large fraction of the total accretion power.Comment: Accepted for publication as a Letter in MNRA

Dust in 3C324

The results of a deep submillimetre observation using SCUBA of the powerful radio galaxy 3C324, at redshift z=1.206, are presented. At 850 microns, emission from the location of the host radio galaxy is marginally detected at the 4.2 sigma level, 3.01 +/- 0.72 mJy, but there is no detection of emission at 450 microns to a 3 sigma limit of 21 mJy. A new 32 GHz radio observation using the Effelsberg 100m telescope confirms that the sub-millimetre signal is not associated with synchrotron emission. These observations indicate that both the mass of warm dust within 3C324, and the star formation rate, lie up to an order of magnitude below the values recently determined for radio galaxies at z = 3 to 4. The results are compared with dust masses and star formation rates derived in other ways for 3C324.Comment: 5 pages LaTeX, including 1 figure. Accepted for publication in MNRA

The Eastern Arm of M83 Revisited: High-Resolution Mapping of 12CO 1-0 Emission

We have used the Owens Valley Millimeter Array to map 12CO (J=1-0) along a 3.5 kpc segment of M83's eastern spiral arm at resolutions of 6.5"x3.5", 10", and 16". The CO emission in most of this segment lies along the sharp dust lane demarking the inner edge of the spiral arm, but beyond a certain point along the arm the emission shifts downstream from the dust lane to become better aligned with the young stars seen in blue and H-beta images. This morphology resembles that of the western arm of M100. Three possibilities, none of which is wholly satisfactory, are considered to explain the deviation of the CO arm from the dust lane: heating of the CO by UV radiation from young stars, heating by low-energy cosmic rays, and a molecular medium consisting of two (diffuse and dense) components which react differently to the density wave. Regardless, the question of what CO emission traces along this spiral arm is a complicated one. Strong tangential streaming is observed where the arm crosses the kinematic major axis of the galaxy, implying that the shear becomes locally prograde in the arms. Inferred from the streaming is a very high gas surface density of about 230 solar masses/pc**2 and an arm-interarm contrast greater than 2.3 in the part of the arm near the major axis. Using two different criteria, we find that the gas at this location is well above the threshold for gravitational instability -- much more clearly so than in either M51 or M100.Comment: Accepted for publication in ApJ. 25 pages, 5 figures. Manuscript in LaTeX, figures in pdf. Fig 3 in colo

CO(1-0), CO(2-1) and Neutral Gas in NGC 6946: Molecular Gas in a Late-Type, Gas Rich, Spiral Galaxy

We present "On The Fly" maps of the CO(1-0) and CO(2-1) emission covering a 10' X 10' region of the NGC 6946. Using our CO maps and archival VLA HI observations we create a total gas surface density map, Sigma_gas, for NGC 6946. The predominantly molecular inner gas disk transitions smoothly into an atomic outer gas disk, with equivalent atomic and molecular gas surface densities at R = 3.5' (6 kpc). We estimate that the total H2 mass is 3 X 10^9 Mo, roughly 1/3 of the interstellar hydrogen gas mass, and about 2% of the dynamical mass of the galaxy at our assumed distance of 6 Mpc. The value of the CO(2-1)/CO(1-0) line ratio ranges from 0.35 to 2; 50% of the map is covered by very high ratio, >1, gas. The very high ratios are predominantly from interarm regions and appear to indicate the presence of wide-spread optically thin gas. Star formation tracers are better correlated with the total neutral gas disk than with the molecular gas by itself implying SFR is proportional to Sigma_gas. Using the 100 FIR and 21 cm continuum from NGC 6946 as star formation tracers, we arrive at a gas consumption timescale of 2.8 Gyr, which is relatively uniform across the disk. The high star formation rate at the nucleus appears to be due to a large accumulation of molecular gas rather than a large increase in the star formation efficiency. The mid-plane gas pressure in the outer (R > 10 kpc) HI arms of NGC 6946 is close to the value at the radial limit (10 kpc) of our observed CO disk. If the mid-plane gas pressure is a factor for the formation of molecular clouds, these outer HI gas arms should contain molecular gas which we do not see because they are beyond our detection limit

Star Formation Thresholds in Galactic Disks

We report the first results of a detailed study of the star formation law in a sample of 32 nearby spiral galaxies with well-measured rotation curves, HI and H$_2$ (as traced by CO) surface density profiles, and new \Ha CCD photometry. Our results strongly support the view that the formation of gravitationally bound interstellar clouds regulates the onset of widespread star formation -- at least in the outer regions of galactic disks.Comment: Will appear in July 1 ApJ. Abbreviated abstract. Postscript version available at http://www.astro.caltech.edu/~clm

Ongoing massive star formation in the bulge of M51

We studied the HST-WFPC2 observations of the inner kpc of the interacting galaxy M51 in six bands from 2550 to 8140 Angstrom. The images show an oval shaped area ("bulge") of 11x16 arcsec or 450x650 pc around the nucleus, dominated by a smooth population of old stars with overimposed dust lanes. We found 30 bright point-like sources in the bulge of M51; many of these are bright in the UV. They are located in elongated "strings" which follow the general pattern of the dust lanes. The spectral energy distributions of the pointsources are compared with those of clusters or single stars. We present arguments that the pointsources are isolated massive stars or small groups of a few massive stars. The energy distributions are best fitted with those of single stars with 4000<Teff<50000 K, 4.2<log L/Lsun<7.2, and 12<Mstar<200 Msun. We have derived upper limits to the total mass of low mass stars that could be "hiding" within the point sources. For the bluest sources the upper limit is only a few hundred Msun. We conclude that massive stars are formed outside clusters (or in very low mass clusters) in the bulge of M51. The estimated star formation rate in the bulge is 1 to 2x10^(-3) Msun/yr. This star formation rate could be sustained for about 200 to 400 Myrs, suggesting that the ongoing massive star formation in the bulge of M51 is fed/triggered by the interaction with its companion about 400 Mrs ago. Theoretical cloud-models show that CO is destroyed in low extinction clouds near the bright nucleus of M51, so that H_2, [OI] and [CII] are the dominants coolants. This condition favors the formation of massive stars, in agreement with the observations. This mode of massive-star formation in the bulge of M51 may resemble the star formation in the early Universe, when the CO and dust contents were low due to the low metallicity.Comment: 28 pages, 7 PostScript figures, uses aaspp4.sty and epsfig.sty. Accepted for publication in ApJ, V566, February 20, 200

Star Formation in M51 Triggered by Galaxy Interaction

We have mapped the inner 360'' regions of M51 in the 158micron [CII] line at 55'' spatial resolution using the Far-infrared Imaging Fabry-Perot Interferometer (FIFI) on the Kuiper Airborne Observatory (KAO). The emission is peaked at the nucleus, but is detectable over the entire region mapped, which covers much of the optical disk of the galaxy. There are also two strong secondary peaks at ~43% to 70% of the nuclear value located roughly 120'' to the north-east, and south-west of the nucleus. These secondary peaks are at the same distance from the nucleus as the corotation radius of the density wave pattern. The density wave also terminates at this location, and the outlying spiral structure is attributed to material clumping due to the interaction between M51 and NGC5195. This orbit crowding results in cloud-cloud collisions, stimulating star formation, that we see as enhanced [CII] line emission. The [CII] emission at the peaks originates mainly from photodissociation regions (PDRs) formed on the surfaces of molecular clouds that are exposed to OB starlight, so that these [CII] peaks trace star formation peaks in M51. The total mass of [CII] emitting photodissociated gas is ~2.6x10^{8} M_{sun}, or about 2% of the molecular gas as estimated from its CO(1-0) line emission. At the peak [CII] positions, the PDR gas mass to total gas mass fraction is somewhat higher, 3-17%, and at the secondary peaks the mass fraction of the [CII] emitting photodissociated gas can be as high as 72% of the molecular mass.... (continued)Comment: 14 pages, 6 figures, Accepted in ApJ (for higher resolution figures contact the author

A Prediction of Brown Dwarfs in Ultracold Molecular Gas

A recent model for the stellar initial mass function (IMF), in which the stellar masses are randomly sampled down to the thermal Jeans mass from hierarchically structured pre-stellar clouds, predicts that regions of ultra-cold CO gas, such as those recently found in nearby galaxies by Allen and collaborators, should make an abundance of Brown Dwarfs with relatively few normal stars. This result comes from the low value of the thermal Jeans mass, considering that the hierarchical cloud model always gives the Salpeter IMF slope above this lower mass limit. The ultracold CO clouds in the inner disk of M31 have T~3K and pressures that are probably 10 times higher than in the solar neighborhood. This gives a mass at the peak of the IMF equal to 0.01 Msun, well below the Brown Dwarf limit of 0.08 Msun. Using a functional approximation to the IMF, the ultracold clouds would have 50% of the star-like mass and 90% of the objects below the Brown Dwarf limit. The brightest of the Brown Dwarfs in M31 should have an apparent, extinction-corrected K-band magnitude of ~21 mag in their pre-main sequence phase.Comment: 13 pages, 2 figures, to be published in Astrophysical Journal, Vol 522, September 10, 199