8 research outputs found
Gene expression changes with differentiation of cord blood stem cells to respiratory epithelial cells: a preliminary observation
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
- Author
- Aaltonen M
- Abdur Rahman M
- Abell T
- Abide W. Jr
- Acheatel R
- Achiri P
- Acon J
- Adams T
- Affinito S
- Agarwal S
- Aggarwal K
- Aggarwal R
- Ahlström P
- Ahmad A
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- Airaksinen A
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- Yandamuri S
- Yang HEE JUNG
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- Yao H
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- Zadra R
- Zagnoni S
- Zambelli M
- Zbik S
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- Zelenka J
- Zelik J
- Zeuthen E
- Zhai M
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- Zhang Ting
- Zhang Wen
- Zhang X
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- Zhao JIAYI STELLA
- Zhao L
- Zhao P
- Zhao R
- Zhao Y
- Zheng Y
- Zheng Z
- Zhi Y
- Zhong H
- Zhong R
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- Zhou Juan
- Zhou Xingyu
- Zhou Yingyuan
- Zhu Wangqin
- Zhu X
- Zhu Y
- Ziefle S
- Zilz N
- Zineldine A
- Zlatewa R
- Zoghbi J
- Zong C
- Zong D
- Zong X
- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Rheumatology grand rounds loosening of a revision total hip replacement in a 60-year-old woman with longstanding rheumatoid arthritis clinicopathologic conference
- Author
- Ainscow
- Antti-Poike
- Arizono
- Baldini
- Barbara N. Weissman
- Barrack
- Besser
- Black
- Blackburn
- Booth
- Bridges
- Canner
- Chazerain
- Cuckler
- Don L. Goldenberg
- Ellen M. Gravallese
- Enzinger
- Eskola
- Ewald
- Fechner
- Fitzgerald
- Gilbert Brodsky
- Glithero
- Goldenberg
- Goldring
- Goldring
- Gould
- Harris
- Heathcock
- Hecht
- Herman
- Herold
- Horadam
- James Maguire
- Jiranek
- Johnson
- Jupiter
- Katz
- Kim
- Kim
- Leach
- Levin
- Levitsky
- Lin
- McCullough
- McLaughlin
- Perhala
- Poss
- Quale
- Sany
- Tigges
- Wray
- Publication venue
- 'Wiley'
- Publication date
- Field of study
About the Existence of Common Internal Causes of Recent Latin American Currency Crises
- Author
- &
- Abdington Mosley
- Alejandro Grisanti
- Andrew M Warner
- Andr� Minella
- Antonio Faiola
- Barbara Fritz
- Barbara Fritz
- Barbara Fritz
- Barcelona
- Barry
- Barry Eichengreen
- Barry Eichengreen
- Barry Eichengreen
- Bartosz Makowiak
- Benedict Clements
- Bob Woodward
- Cameron Gavin
- Carlos Carvalho
- Carlos Carvalho
- Carlos Doellinger
- Celso L Martone
- Christian Freres
- Christian Henn
- Claus Tigges
- Coordinadores Guiti�n
- Craig Burnside
- Daniel Kinney
- Daniel Oks
- David M Gould
- Detlef Nolte
- Dirk Effenberger
- Donald R Fraser
- Eli Diniz
- Eliana
- Enrique G Mendoza
- Ernesto
- Erwin
- Fahrettin Yagci
- Felix
- Frances Stewart
- Francesco
- Frankfurter Allgemeine Sonntagszeitung
- Geneva Shah
- Giancarlo Corsetti
- Giancarlo Gandolfo
- Gilberto Calcagnotto
- Grecia M Marrufo
- Hamburg Calvo
- Horst Siebert
- Hugo Nochteff
- Ibero-Amerika
- Ibero-Amerika
- Ilan Goldfajn
- Ilan Goldfajn
- Jeffrey A Frankel
- Ji Wu
- Jorge Martinez-Vazquez
- Jorge Schvarzer
- Jos� Gonzalez-Anaya
- J�rn
- Karl E Case
- Kiser
- L Sherry
- Linda
- Luis M Linde
- M Murillo
- Manfred G�rtner
- Marcelo
- Marcelo Diamond
- Marcos J Mendes
- Marcus
- Martin
- Martin Feldstein
- Martin Feldstein
- Martin Feldstein
- Martin Wolf
- Martinez Peria
- Mexico *for
- Meyer-Stamer
- Michael
- Michael Mussa
- Moritz Kraemer
- Nadir
- Paul R Krugman
- Paul R Krugman
- Peter B Kenen
- Peter M Garber
- Philip R Lane
- Pir�mide Madrid Edwards
- Rafael Gamboa
- Raquel
- Renato Boschi
- Ricardo
- Ricardo Caballero
- Ricardo J Caballero
- Ricardo J Caballero
- Robert J Shiller
- Robert R Moore
- Roland I Mckinnon
- Rolf Schinke
- Rudiger Dornbusch
- Rudiger Dornbusch
- Rudiger Dornbusch
- Rudiger Dornbusch
- Rudiger Dornbusch
- R�o Grupo De
- Sabine Kurtenbach
- Sabine Kurtenbach
- Sabine Kurtenbach
- Sandra Weiss
- Sayuri Shiria
- Sebastian Edwards
- Sebastian Edwards
- Sebastian Edwards
- September Gall
- Shang-Jin Wei
- Shang-Jin Wei
- Source: Workgroup
- Stephany Griffith-Jones
- Stephen D Morris
- Stuttgart
- Thomas
- Thomas Glaessner
- Vervuert
- Victoria
- William C Gruben
- William C Gruben
- William C Gruben
- Wolfgang
- World Bank
- World Bank
- World Bank
- �berarbeitete Zweite
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2003
- Field of study
Multivalent proteoglycan modulation of FGF mitogenic responses in perivascular cells
- Author
- A Armulik
- AK Powell
- Alfonso Colombatti
- B Sennino
- B-M Loo
- Barbara Ranscht
- BL Allen
- BM Kenyon
- C Francavilla
- C-W Chen
- CJ Robinson
- CL Chu
- CL Chu
- D Virgintino
- D Virgintino
- Daniela Zanocco
- E Sanchez-Heras
- FJ Huang
- G Pluschke
- H Rahmoune
- H Zhu
- IT Makagiansar
- IT Makagiansar
- J Kreuger
- J Schlessinger
- K Forsten-Williams
- K Hirschi
- K Suyama
- KA Grako
- KA Grako
- L Goretzki
- L Pellegrini
- M Delehedde
- M Gopalakrishnan
- M Maccarana
- Martin Denzel
- MM Fuster
- N Gotoh
- N Turner
- NJ Harmer
- O Ostrovsky
- OA Ibrahimi
- P Lindahl
- Pietro Bulian
- Roberto Perris
- RT Böttcher
- S Guimond
- S Song
- Sabrina Cattaruzza
- SE Guimond
- SE Stringer
- U Cavallaro
- U Ozerdem
- U Ozerdem
- U Ozerdem
- U Ozerdem
- U Ozerdem
- U Tigges
- Ugo Cavallaro
- Ugur Ozerdem
- VN Patel
- WB Stallcup
- William B. Stallcup
- X Zhang
- Y Luo
- Z Zhang
- ZL Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
An exploration of the link between adult attachment and problematic Facebook use
- Author
- A Acar
- A Blachnio
- A Blachnio
- A Dunne
- A Nadkarni
- A Schimmenti
- AD Smock
- AF Hayes
- AL Forest
- AL Gonzales
- AN Schore
- AP Dempster
- BA Feinstein
- Barbara M. Byrne
- BB Tigges
- BG Tabachnik
- C Hazan
- CG Sibley
- CG Sibley
- CH Wu
- D Siegel
- DA Thornton
- DD Rucker
- DP Schmitt
- DY Lee
- E Frison
- E Kross
- EA Carlson
- EC Tandoc
- F Gibbons
- G Rao
- G Seidman
- GC Nitzburg
- H Appel
- H Gangadharbatla
- H Lin
- Hae-Young Kim
- I Bretherton
- J Bowlby
- J Bowlby
- J Bowlby
- J Bowlby
- J Cassidy
- J Cassidy
- J Davila
- J Fox
- J Hart
- J Kim
- JA Oldmeadow
- JD Henry
- JR Crawford
- K Alpizar
- K Bartholomew
- K Bartholomew
- K Ellis
- KA Brennan
- KF Weir
- KJ Preacher
- KJ Preacher
- L Festinger
- L Qui
- LA Emery
- LA Reed
- LA Sroufe
- LD Rosen
- M Koc
- M Main
- M Mikulincer
- M Mikulincer
- M Mikulincer
- M Mikulincer
- M Mikulincer
- M Rosenberg
- MA Moreno
- MA Moreno
- MN Steers
- NB Ellison
- NL Collins
- O Gil-Or
- P Shachaf
- PR Pietromonaco
- PR Shaver
- R Basilisco
- RA Griffiths
- RC Fraley
- RC Fraley
- RIM Dunbar
- RW Robins
- S Livingstone
- S Malik
- S Mehdizadeh
- S Srivastava
- S Utz
- SH Lovibond
- T Pierce
- T Ryan
- TC Ognibene
- TM Field
- Y Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Elucidating the burden of recurrent and chronic digital ulcers in systemic sclerosis: long-term results from the DUO Registry
- Author
- ABAD HERNANDEZ MA
- ABDIU G
- ABDUL F
- ABIGNANO G
- ADAMSKI H
- ADOUE D
- AGARD C
- AGNES S
- AHMADI K
- AIRO P
- AIZPURU EMF
- AKANAY-DIESEL S
- AKIL M
- ALBERTSSON K
- ALEGRE SANCHO JJ
- ALLANORE Y
- ALMEIDA I
- ALONSO JJ
- ALONSO PN
- ALPERI LOPEZ M
- ALSHEIMER B
- ALVES J
- AMOROSO A
- ANDERSON M
- ANDRESEN J
- ANGELES AQUIRRE M
- ANTIVALLE M
- ARAGON A
- ARIES P
- ARTHANARI S
- ASLAKSEN HK
- ASLANIDIS S
- ASSMANN G
- ASSOUS N
- ATHANASSIOU P
- ATHIVEER P
- AUSSERWINKLER M
- BACHET P
- BAINES C
- BAJOCCHI G
- BAKKEHEIM V
- BAKLAND G
- BALDUCCHI J-P
- BARATAY A
- BARBADO J
- BARCA BA
- BARCAT D
- BARTH S
- BATTAGLIA E
- BATTELINO M
- BAUDOIN P
- BAUMANN C
- BECERRA ND
- BECKER M
- BECVAR R
- BEKOU V
- BELCH J
- BELIN E
- BELIZNA C
- BELLIDO D
- BELLISAI F
- BELLISSIMO S
- BELLOLI L
- BELLONI B
- BENDVOLD A
- BENENATI A
- BENETON N
- BERETTA L
- BEREZNE A
- BERG W
- BERNIT E
- BERTHIER S
- BESSIS D
- BEYER C
- BEZANAHARY H
- BIJKERK C
- BIJL M
- BITTER H
- BLAISE S
- BLAISON G
- BLANCO JJR
- BLANCO JS
- BLANK N
- BLAQUIERE S
- BLASCHKE S
- BLOCHING HH
- BLUM L
- BLUME J
- BOECKER A
- BOESENBERG I
- BOHMOVA J
- BOILEAU J
- BOMBARDIERI S
- BONTE-MINEUR F
- BOOTSMA H
- BORO D
- BORSETTO M
- BORTLIK L
- BORTOLUZZI A
- BOSELLO C
- BOULON C
- BOUSSELY N
- BÖHM J
- BRACIN T
- BRAND A
- BRAND H
- BRAUN F
- BRAVETTI V
- BROLL H
- BROUWER L
- BROWN S
- BRUCKNER L
- BRUIJN G
- BRUYN GAW
- BRUZZONE M
- BUCCI R
- BUCH M
- BUEHRE H
- CAAMANO ML
- CABANE J
- CALABUIG JR
- CALLEJAS JL
- CALVO JAMIE
- CALVO JAVIER
- CAMARA I
- CAMPS MT
- CANNIEUX V
- CANTATORE F
- CAPUANO B
- CARIGNOLA R
- CARPENTIER P
- CARRARO V
- CARRASCO JA
- CARRO A
- CARTRY O
- CASTELLVI I
- CAZALETS-LACOSTE C
- CHAHAL S PARVINDER
- CHAIGNEAU A-F
- CHARLANNE H
- CHATELUS E
- CHATTOPADHYAY C
- CHAUVEHEID M-P
- CHEVRANT-BRETON J
- CHIAROLANZA I
- CHICINAS-BICA D
- CHIFFLOT H
- CHOKCHAMPA T
- CHOONG LM
- CHROMIK S
- CIMINO R
- CIPRIANI P
- CODULLO V
- COELHO P
- COHEN JD
- COLACI M
- COLEMAN JV
- COLLET E
- COLONNA L
- CONEJERO AM
- CONSTANS J
- COPPERE B
- COPPOCK J
- CORDEIRO A
- Cornelisse Peter
- CORRADO A
- CORTEGUERA M
- CORTINA EL
- COSTA J
- COURAUD A
- COURET B
- COZZI F
- CRESPO M
- CRUZ A
- CRUZ J
- CUOMO G
- D'CRUZ D
- DADBAN A
- DALL’ARA F
- DANDURAND M
- DE ANGELI R
- DE BEUS WM
- DE BOIS M
- DE DONNO A
- DE JONG AJL
- DE KANTER MAE
- DE LA CRUZ TAPLADOR C
- DE LA PUENTE C
- DE LA TORRE RG
- DE MATTIA M
- DE RAMON E
- DE SANTIS M
- DE SONNAVILLE PBJ
- DE VICUNA RG
- DE VITA S
- DEBOVES O
- DECAUX O
- DEININGER F
- DEL CARMEN FREIRE M
- DEL CARMEN ORTEGA DE LA O M
- DEL CARMEN TORRES MARTIN M
- DEL CASTILLO MR
- DEL LA PENA LEFEBVRE PG
- DEL MAR RIPOLL MACIAS M
- DEL PAPA N
- DEL PINO J
- DEL RIO AH
- DELFS A
- DELGADO EG
- DELGADO PC
- DELLA ROSSA A
- DEN HENGST CW
- DENTON C
- Denton Christopher P
- DEPPERMANN N
- DESMURS-CLAVEL H
- DEUSCHLE K
- DI DONATO I
- DIANCOURT M-H
- DIAZ LOPEZ JB
- DIAZ JJ
- DIETL S
- DILL-MÜLLER D
- DIMITROULAS T
- DIMOPOULOU D
- DINULESCU M
- DIOT E
- DISTLER J
- DISTLER O
- DIVOY C
- DOBSON J
- DOEFFEL-HANTZ V
- DOLHAIN RJEM
- DOLNICAR AS
- DOUTRE M-S
- DOVERI M
- DRAGUN D
- DREXLER E
- DROITCOURT C
- DROSOS AA
- DUBEY S
- DUCHENE F
- DUMONTEIL S
- DUPAS S
- DURAND JM
- DURANT C
- DUVAL-MODESTE A-B
- DYBALLA J
- EBEL J
- EGGELMEIJER F
- EGURBIDE M VICTORIA
- EILBACHER P
- ELEZOGLOU A
- ENDERLEIN M
- ERFURT-BERGE C
- ESPINOSA G
- EWALS J
- FABIENNE Z
- FAGGIOLI P
- FAIZAL A
- FARCAS C
- FARGE D
- FAUCHAIS A-L
- FAUSER H
- FEDEROW I
- FEIK R
- FELDMANN R
- FELIUS ID
- FELL I
- FERNANDEZ C
- FERNANDEZ J
- FERNANDEZ NC
- FERNANDEZ S
- FERRACCIOLI G
- FERRANDIZ D
- FERREIRA PA
- FERREIRA R
- FERRI C
- FIENE M
- FIERLBECK G
- FILLOY JAM
- FISCHER-BETZ R
- FITO MANTECA MC
- FLAIG W
- FOELDVARI I
- FOJTIK Z
- FOTI R
- FRAMBACH Y
- FRANCES C
- FREIRE GONZALEZ M
- FRETTER P
- FREY P
- FUNKERT A
- FUSARO E
- FUZIBET JG
- GABRIELLI A
- GACHES F
- GALANOPOULOS N
- GALANOPOULOU V
- GALEAZZI M
- GALLUCCIO F
- GARCIA A
- GARCIA P-V
- GARYFALLOS A
- GATTI S
- GAUBITZ M
- GAUSE A
- GAWLIK A
- GENTH E
- GEORGI J
- GERARDS AH
- GERBER A
- GERBER A
- GERDES VEA
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- GEURTS MAW
- GIACOMELLI R
- GIARDINA A
- GIL H
- GIL JG
- GINES MARTINEZ F
- GIRARD-MADOUX M-H
- GIUGGIOLI D
- GJESDAL CG
- GKOUGKOURELAS I
- GLAESER R
- GOEKOOP R
- GOMMESEN P
- GONZALEZ GONZALEZ ML
- GONZALEZ HOMBRADO L
- GORDON P
- GOUDRAN G
- GÖTTL K-H
- GRAFFIN B
- GRANDAUNET B
- GRANEL B
- GRANEL-BROCARD F
- GRANGE C
- GRASSI W
- GRECO M
- GRIER A
- GRiLO A
- GROENENDAEL J
- GROENENDAEL JHLM
- GUENTHER C
- GUENZEL J
- GUERTLER I
- GUILLEVIN L
- Guillevin Loic
- HACHULLA E
- HAENTSCH J
- HAFNER F
- HAHN K
- HAK AE
- HALL F
- HALLECKER A
- HALLENGREN C STAHL
- HALLER G
- HALLERMANN C
- HAN KH
- HAPKA S
- HARALAMBOS B
- HARLE J-R
- HARMUTH W
- HARRIS H
- HARTMANN F
- HASSEL R
- HATRON P-Y
- HAUST M
- HAVERMAN J
- HAZENBILLER A
- HEIN R
- HELD M
- HELDMANN F
- HELLMICH B
- HELLSTROM H
- HELMUT E S
- HEMBERG M
- HENKEMEIER U
- HERING J
- HERMANNS G
- HERMANSSON E
- HERNAN MGB
- HERR U
- HERRGOTT I
- HERRICK A
- HESSE S
- HEURKENS AHM
- HILDEBRANDT B
- HILLEBRECHT C
- HIMSEL A
- HINTNER H
- HIRSCHL M
- HISSINK MULLER W
- HOFF N-P
- HOFFMANN A
- HOFFMANN-VOLD A-M
- HOLL R
- HOLMSTRAND A
- HOT A
- HOUBEN H
- HOUTMAN PM
- HUEGEL R
- HUERTAS MP
- HUETTIG B
- HUIZINGA TWJ
- HULSMANS H
- HUNDSTORFER M
- HURKENS T
- ILLMER X
- IMBERT B
- INSUA S ANTONIO
- IVERSEN LV
- IVORRA JR
- JACOBS PJC
- JAHANGIER DE VEEN ZN
- JAHNKE K
- JANSCHE S
- JANSEN T
- JANSSEN M
- JARRETT S
- JEAN R
- JEGO P
- JEURISSEN MEC
- JOERG K
- JORDAN S
- JOURDAIN N
- JUST H
- KAARTO A
- KAASJAGER HAH
- KACZMARCZYK A
- KAEDING U
- KAHL S
- KALSTAD S
- KALTSONOUDIS E
- KAMALI S
- KAMPE-JUZAK E
- KANOTE A
- KAPLANSKI G
- KARAENKE P
- KARLHOFER F
- KARLSMARK T
- KARSTILA K
- KATZEMICH A
- KAUFMANN P
- KAYSER M
- KELLNER C
- KERN S
- KESHTMAND H
- KETTENBACH A
- KHAU VAN KIEN A
- KILLINGER Z
- KIRCHBERG S
- KIRSCHKE J
- KLASSON J
- KLEIN E
- KLEINER H-J
- KMECOVA Z
- KNAAPEN HKA
- KNEITZ C
- KNIJFF-DUTMER E
- KNOBLER R
- KNOEBEL K
- KNUDSEN JB
- KOCH M
- KOLDINGSNES W
- KOLLE H
- KORBER H
- KORNELUK-THOR G
- KOSTRZEWA E
- KOUTROUMBAS A
- KRAUSE A
- KRAUSE J-O
- KREMER K
- KREUTER A
- KRIEG T
- Krieg Thomas
- KRITIKOS I
- KROG B
- KRUPP E
- KRUSE S
- KUEN-SPIEGL M
- KUIPER-GEERTSMA DG
- KUNZE S
- KURTHEN R
- KYNDT X
- LA CORTE R
- LAMBERT M
- LANDEWE RBM
- LANDRON C
- LANGER H
- LANTING PJH
- LAPADULA G
- LARRANAGA JR
- LAUNAY D
- LAURIN CU
- LAUTERWEIN B
- LAZARETH I
- LE CLECH C
- LE QUELLEC A
- LEBRUN CEI
- LEE H-H
- LEGUY-SEGUIN V
- LEMSON S
- LETREMY A
- LEVENEUR Y
- LILJEQUIST E
- LIND K
- LINKE M
- LOEFFLER C
- LOK C
- LOMBARDI S
- LOPEZ LONGO FJ
- LOPEZ B
- LOPEZ JCF
- LOPEZ MR
- LOSADA L
- LOUSIJÄRVI R
- LOUSTAUD-RATTI V
- LOZANO A
- LUCKGENS C
- LUETHKE K
- LUKAC J
- LUNARDI C
- LUNGWITZ A
- LUPASCHKO S
- MACEIRAS F
- MACEJOVA Z
- MADAULE S
- MADHOK R
- MADLAND TM
- MAGLIONE W
- MAGY-BERTRAND N
- MAILLARD H
- MAKINEN H
- MALAVOLTA N
- MANEA P
- MANEIRO JR
- MANGER K
- MANZANEDO VS
- MARASINI B
- MARHUENDA AR
- MARINA P
- MARQUARDT T
- MARTIN I
- MARTIN T
- MARX J
- MASCARO JM
- MASOLINI P
- MATEO BERNARDO I
- MATEO FJN
- MATHIEU A
- MATTAT K
- MATUCCI CERINIC M
- Matucci-Cerinic Marco
- MAURER B
- MAURIER F
- MAY D
- MAYER L
- MAZODIER K
- MAZZONE A
- MAZZUCA S
- MCHUGH N
- MCSWIGGAN S
- MEDINA F
- MEGAHED M
- MEIER L
- MEIER U
- MEJIA JC
- MENDOZA AZ
- MENGDEN T
- MENSING C
- MENSING H
- MERA A
- MERK B
- MERKERT R
- MESARIC P
- MESSER G
- METTLER S
- METZ S
- METZLER C
- MICHAILIDOU M
- MICHON-PASTUREL U
- MIDTVEDT O
- MIFTARAJ M
- MIGUELEZ R
- MISERY L
- MITCHELL A
- MITTAG M
- MOGENSEN M
- MOHAMMAD A
- MOINZADEH P
- MOITON M-P
- MOLDERS N
- MOLINE T
- MOLLER B
- MONSHAUSEN M
- MONSHI B
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- MONTES J
- MONTORO ÁLVAREZ M
- MOOLENBURGH JD
- MOOSIG F
- MOOTS R
- MORELL S
- MORITZ D
- MORRIS A
- MORRISON C
- MOSCA M
- MOSQUERA JA
- MOTA R
- MOULIS G
- MOUTHON L
- MPASDAGIANNI D
- MUEGLICH C
- MULDER DJ
- MULE R
- MULLER G
- MUNOZ J
- MURPHY K
- MUSSI A
- MÜLLER-LADNER U
- NAAFS B
- NADERI Y
- NADESALINGAM K
- NADÈGE C
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- NEMEC P
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- NICOL IM
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- NIEDEMEIER A
- NIEFANGER K
- NIELEN C
- NIGRO A
- NINET J
- NISAR M
- NOORDZIJ M
- NORDIN A
- NORDVAG B-Y
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- NÜTZEL B
- O'ROURKE M
- OCHIEL R
- OCHS W
- OELSNER M
- OLESEN A
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- PFEIFFER C
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- PLAUMANN K
- PLEIMES M
- PODDA M
- PODOBINSKA M
- POMPONIO G
- PONTE C
- POPP-HABELER J
- POUBEAU P
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- PRIOLLET P
- PROCHAZKOVA L
- PROS A
- PUGNET G
- PUPPO F
- QUEMENEUR T
- QUEYREL V
- QUÉRÉ I
- RABANEDA EV
- RABE B
- RAFFIER B
- RAMAKERS LINSSEN-
- RAMASSAMY A
- RAMOS B
- RAMOS M
- RAMOS PC
- RAPP P
- RASCHE C
- RAUEN T
- REEMTSEN R
- REGUIAI Z
- REISCHEL N
- REMANS PH
- RESENDE C
- RICCIERI V
- RICHEZ C
- RICHTER E
- RIEMEKASTEN G
- RIEMENSPERGER U
- RISO N
- RIVERA A
- RIVIERE S
- RIZK M
- RIZZO M
- ROBAKIDZE-TORBAHN M
- ROBLOT P
- RODRIGUES AC
- RODRIGUEZ DE LA SERNA A
- RODRIGUEZ MAP
- RODRIGUEZ TRV
- RONDAY H
- ROSATO E
- Rosenberg Daniel
- ROWAN M
- RUBIO M
- RUEDA A
- RULLIER P
- RUMBAUR C
- RUMPEL H
- RUSCHENBURG J
- RUSCITTI P
- RUSHENTSOVA U
- RYDVALD Y
- SAAL J-G
- SAAR P
- SABIO JM
- SADEGHLAR F
- SAEZ L
- SAILLER L
- SALERNO R
- SALSANO F
- SALVARANI C
- SANCHEZ ATRIO AI
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- SARACCO M
- SARDY M
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- SAUTNER J
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- SCHANZ S
- SCHATTON K
- SCHILDT K
- SCHLEENBECKER H
- SCHLEINITZ N
- SCHLIMMER P
- SCHMEISER T
- SCHMIDT K
- SCHMIDT M
- SCHMIDT-BOSSHARD R
- SCHNARR S
- SCHNEIDER K
- SCHOEFFEL D
- SCHOLZ J
- SCHOUFFOER AA
- SCHUART T
- SCHUCH F
- SCHUERWEGH AJM
- SCHUETZ N
- SCHULTZ L
- SCHULZ W
- SCHULZE K
- SCHUSTER J
- SCHWARTING A
- SCHWEDA K
- Schwierin Barbara
- SCHWUERZER-VOIT M
- SCORZA R
- SEHR T
- SEIDEL M
- SEIP M
- SELMI C
- SEMMELWEIS K
- SEMMLER M
- SERAFINO L
- SEVERINO A
- SEVESTRE M
- SEYS P
- SÉNÉSCHAL J
- SHEIK N
- SHEIKH N
- SIBILIA J
- SIEWERTSZ VAN REESEMA D
- SIEWERTSZ VAN REESEMA DR
- SILVA F
- SILVA I
- SIMEON CP
- SINHA A
- SKINGLE S
- SKOMSVOLL J
- SKOPINSKI S
- SKOWRON F
- SMIT AJ
- SMRZOVA A
- SMYTH A
- SODERLIN M
- SONDERGAARD KH
- SOPENA B
- SORDET C
- SOUKUP T
- SPARSA A
- SPERLING S
- SPEYER I
- SPOORENBERG A
- STARZ H
- STEIN T
- STEINBRINK K
- STETTER M
- STICHERLING M
- STISI S
- STOLK JN
- STORCK-MUELLER K
- STRAND EK
- STROES ESG
- STROHAL R
- SUCHY D
- SUNDERKÖTTER C
- SWAAK AJG
- SWIFT D
- SYKES H
- TAGGESELLE J
- TAIEB A
- TAKACS M
- TALOUR K
- TASENDE JAP
- TAYLOR C
- TEGMARK S
- TERLIZZI N
- THOMSEN RS
- THONHOFER R
- THORSSON C
- TIEV K
- TIGGES C
- TILLEY D
- TODOLI JA
- TOELLER S
- TOLEDANO C
- TOMI N
- TON E
- TONY H-P
- TRAUTINGER F
- TRENADO MSS
- TRINCONE S
- TRIOLO G
- TROG L
- TROTTA F
- TRUCHETET E
- TSIFETAKI N
- UBELS F
- UGHI N
- ULLRICH GUENTHER C
- UNHOLZER A
- USON J
- VACCA A
- VALENTIJN R
- VALENTINI G
- VALESINI G
- VAN BRUSSEL MS
- VAN DAELE PLA
- VAN DE REE MA
- VAN DEN BIJL AE
- VAN DEN HOOGEN FHJ
- VAN DER LUBBE P
- VAN DER VEEN MJ
- VAN DURME C
- VAN GAMEREN I
- VAN GULDENER C
- VAN HAGEN PM
- VAN KRUGTEN M
- VAN NEER FJMA
- VAN PAASSEN H
- VAN PAASSEN P
- VAN VEEN GJM
- VAN WOERKOM JM
- VAN ZEBEN D
- VARCASIA G
- VASILE M
- VASILOPOULOS D
- VAZQUEZ JLG
- VEALE D
- VEGOUDAKI G
- VENGEMYR K
- VERCOUTERE W
- VERNER D
- VIALLARD J-F
- VIDAL E
- VIDQVIST K-L
- VILLAVERDE V
- VINCENT R
- VINGREN T
- VISSER H
- VITOVA J
- VLACHOYANNOPOULOS P
- VLOEDBELD M
- VON BILDERLING PB
- VON BORMANN-ALTMEYER C
- VON ELLING A
- VON OELHAFEN J
- VONK MC
- VOS PAJM
- VOSKUYL AE
- VOSS B
- VOSWINKEL J
- WAGNER N
- WAHL D
- WAHN H
- WALDHEIM E
- WALRAVENS M
- WASMUTH J-C
- WEISS E
- WEITOFT T
- WELZEL J
- WERNITZSCH H
- WERTHMANN M-L
- WESSEL C
- WESTEDT ML
- WESTRA R
- WHITE-ALAO B
- WIERZBICKA-HAINAUT E
- WILHELM HU
- WILLEMS HPJ
- WILLFORT-EHRINGER A
- WILLIAMS C
- WILLIG B
- WIPFF J
- WITTNER M
- WLODARZ M
- WOJTASIK G
- WORM M
- WÖLLERSDORFER E
- WRAGG E
- WUERZBURG I
- WYKES J
- XU Y
- YEBRA M
- YOUSSEF H
- YOUSSEF HM
- ZABEL M
- ZAHARIOUDAKI A
- ZAHORA R
- ZEMANOVA I
- ZENI S
- ZENONE T
- ZEUNER R
- ZIAI M
- ZIJLSTRA TR
- ZIMBA S
- ZINGARELLI S
- ZOULIM A
- ZUBIETA J
- ZUILY S
- ZUPER R
- ZWENGER S
- Publication venue
- place:BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
- Publication date
- 01/01/2016
- Field of study
Objectives Digital ulcers (DUs) occur in up to half of patients with systemic sclerosis (SSc) and may lead to infection, gangrene and amputation with functional disability and reduced quality of life. This study has elucidated the burden of SSc-associated DUs through identification of four patient categories based on the pattern of DU recurrence over a 2-year observation period.Methods Patients with SSc-associated DUs enrolled in the Digital Ulcers Outcome Registry between 1 April 2008 and 19 November 2013, and with 2years of observation and 3 follow-up visits during the observation period were analysed. Incident DU-associated complications were recorded during follow-up. Work and daily activity impairment were measured using a functional assessment questionnaire completed by patients after the observation period. Potential factors that could predict incident complications were identified in patients with chronic DUs.Results From 1459 patients, four DU occurrence categories were identified: 33.2% no-DU; 9.4% episodic; 46.2% recurrent; 11.2% chronic. During the observation period, patients from the chronic category had the highest rate of incident complications, highest work impairment and greatest need for help compared with the other categories. Independent factors associated with incident complications included gastrointestinal manifestations (OR 3.73, p=0.03) and previous soft tissue infection (OR 5.86, p=0.01).Conclusions This proposed novel categorisation of patients with SSc-associated DUs based on the occurrence of DUs over time may help to identify patients in the clinic with a heavier DU burden who could benefit from more complex management to improve their functioning and quality of life