Arc development in the Apennines

In central Italy, geometry, kinematics, and tectonic evolution of the late Neogene Umbrian Arc, which is one of the main thrusts of the northern Apennines, have long been studied. Documented evidence for orogenic curvature includes vertical-axis rotations along both limbs of the arc and a positive orocline test along the entire arc. The curvature’s cause is, however, still unexplained. In this work, we focused our attention on the southern portion of the Umbrian Arc, the so-called Olevano-Antrodoco thrust. We analyze, in particular, gravity and seismic reflection data and consider available paleomagnetic, stratigraphic, structural, and topographic evidence from the central Apennines to infer spatial extent, attitude, and surface effects of a mid-crustal anticlinorium imaged in the CROP-11 deep seismic profile. The anticlinorium has horizontal dimensions of about 50 by 30 km and is located right beneath the Olevano-Antrodoco thrust. Stratigraphic, structural, and topographic evidence suggests that the anticlinorium produced a surface uplift during its growth in early Pliocene times. We propose an evolutionary model in which, during late Neogene time, the Olevano-Antrodoco thrust developed in an out-of-sequence fashion and underwent about 16° of clockwise rotation when the thrust ran into and was then raised and folded by the growing anticlinorium (late Messinian-early Pliocene time). This new model suggests a causal link between mid-crustal folding and surficial orogenic curvature that is consistent with several available data sets from the northern-central Apennines; more evidence is, however, needed to fully test hypothesis. Additionally, due to the occurrence of mid-crustal basement-involved thrusts in other orogens, this model may be a viable mechanism for arc formation elsewhere

Arc development in the Apennines

In central Italy, the geometry, kinematics, and tectonic evolution of the late Neogene Umbrian Arc, which is one of the main thrusts of the northern Apennines, have long been studied. Documented evidence for orogenic curvature includes vertical axis rotations along both limbs of the arc and a positive orocline test along the entire arc. The cause of the curvature is, however, still unexplained. In this work, we focus our attention on the southern portion of the Umbrian Arc, the so-called Olevano- Antrodoco thrust. We analyze, in particular, gravity and seismic-reflection data and consider available paleomagnetic, stratigraphic, structural, and topographic evidence from the central Apennines to infer spatial extent, attitude, and surface effects of a midcrustal anticlinorium imaged in the CROP-11 deep seismic profile. The anticlinorium has horizontal dimensions of ~50 by 30 km, and it is located right beneath the Olevano- Antrodoco thrust. Stratigraphic, structural, and topographic evidence suggests that the anticlinorium produced a surface uplift during its growth in early Pliocene times. We propose an evolutionary model in which, during late Neogene time, the Olevano- Antrodoco thrust developed in an out-of sequence fashion and underwent ~16° of clockwise rotation when the thrust ran into and was then raised and folded by the growing anticlinorium (late Messinian–early Pliocene time). This new model suggests a causal link between midcrustal folding and surficial orogenic curvature that is consistent with several available data sets from the northern and central Apennines; more evidence is, however, needed to fully test our hypothesis. Additionally, due to the occurrence of midcrustal basement-involved thrusts in other orogens, this model may be a viable mechanism for arc formation elsewhere

Geomorphology and hydrochemistry of 12 Alpine lakes in the Gran Paradiso National Park, Italy

Twelve Alpine lakes located in the Gran Paradiso National Park, in the western Italian Alps, were sampled during the ice free period in 2008 and analysed for the main morphological, chemical and physical variables in relation to the characteristics of their watershed, with the aim to create a reference database for present and future ecological studies and to support conservation politics with scientific data. The results highlighted that weathering process and direct precipitation input are the main factors determining the hydrochemistry of the studied lakes; moreover the morphological characteristics highly affects the physical properties of the lakes starting from stratification process. The acidification status, the atmospheric input of N compounds and the supply of nutrients were considered in detail. The studied lakes seem to be well preserved by acidification risk. Comparing data from Gran Paradiso National Park with data from European mountain regions ranging in N deposition rates, allows to consider long range anthropogenic impact: the detection of relative low Total Nitrogen (TN) concentration is not necessarily a synonym of a soft impact of long range pollutants, being the final nitrogen concentration dependent from retention process, closely related to catchment characteristics, besides N deposition rates; moreover the dominance of Inorganic Nitrogen (IN) on Organic Nitrogen (ON) highlights that the lakes are interested by N deposition and probably by long range transport of pollutants produced in the urbanized area surrounding the massif. However the Gran Paradiso National Park area is by far less affected by atmospheric pollutants than other Alpine regions, as the Central Alps. Total Phosphorus (TP) concentration in Gran Paradiso lakes (1-13 ?g L-1, mean level = 4 ?g L-1) is an index of oligotrophic and ultraoligotrophic conditions and according to Redfield's ratio phosphorus is mainly the phytoplankton growth limiting element, assuming a key role in biological processes and food-web dynamics; the high TN:TP ratio values detected in the studied lakes reflects the low N retention capacity of alpine sparse vegetation by comparison with prairies or forests

Screening of endocrine organ-specific humoral autoimmunity in 47,XXY Klinefelter's syndrome reveals a significant increase in diabetes-specific immunoreactivity in comparison with healthy control men.

The aim of this study was to evaluate the frequency of humoral endocrine organ-specific autoimmunity in 47,XXY Klinefelter’s syndrome (KS) by investigating the autoantibody profile specific to type 1 diabetes (T1DM), Addison’s disease (AD), Hashimoto thyroiditis (HT), and autoimmune chronic atrophic gastritis (AG). Sixty-one adult Caucasian 47,XXY KS patients were tested for autoantibodies specific to T1DM (Insulin Abs, GAD Abs, IA-2 Abs, Znt8 Abs), HT (TPO Abs), AD (21-OH Abs), and AG (APC Abs). Thirty-five of these patients were not undergoing testosterone replacement therapy TRT (Group 1) and the remaining 26 patients started TRT before the beginning of the study (Group 2). KS autoantibody frequencies were compared to those found in 122 control men. Six of 61 KS patients (9.8 %) were positive for at least one endocrine autoantibody, compared to 6.5 % of controls. Interestingly, KS endocrine immunoreactivity was directed primarily against diabetes-specific autoantigens (8.2 %), with a significantly higher frequency than in controls (p = 0.016). Two KS patients (3.3 %) were TPO Ab positive, whereas no patients were positive for AD- and AG-related autoantigens. The autoantibody endocrine profile of untreated and treated KS patients was not significantly different. Our findings demonstrate for the first time that endocrine humoral immunoreactivity is not rare in KS patients and that it is more frequently directed against type 1 diabetes-related autoantigens, thus suggesting the importance of screening for organ-specific autoimmunity in clinical practice. Follow-up studies are needed to establish if autoantibody-positive KS patients will develop clinical T1D

Simulating the Impact of the Global Economic Crisis and Policy Responses on Children in Ghana

Like many countries in sub-Saharan Africa, Ghana is experiencing the impact of the global crisis and the uncertain economic outlook. Indeed, as Ghana’s economy is among the most open in Africa, it is expected that the country has been and will continue to be severely affected by the crisis, although strong export prices of its main exports (gold and cocoa) may at least partially counteract the effects associated with the crisis. The main goal of this paper is to understand the potential impacts of the 2008/9 global crisis on different dimensions of child poverty (monetary, hunger, school participation, child labour and access to health services) in Ghana and to support the policy-maker in designing the most appropriate policy response to counteract the negative effects of the crisis. As timely data are not available, a combined macro-micro economic model to predict the impact of the global crisis on children was developed. Simulations suggest that the financial crisis would increase monetary poverty and hunger across all regions of Ghana, eroding many of the gains made over the past few years. Indeed, in comparison with the year preceding the crisis, instead of a reduction of four percentage points in child monetary poverty in 2011 predicted in the absence of crisis, the simulations indicate a 6.6 percentage point increase, with a continuous increasing pattern over the period of study. The global crisis is also predicted to severely deepen hunger among children, which is simulated to increase up to 6.6 percentage points in 2011 beginning with a sharp increase already in 2009. For both monetary poverty and hunger, the impact of the crisis differs across all regions, with the Eastern, Volta and Greater Accra regions predicted to be the most affected. Children’s participation in schooling and labour, as well as their access to health services, are forecast to be much less affected by the crisis, although it is found to reverse predicted increases in enrolment and health access (with substitution toward more modern types of health services) and forecasted reductions in child labour. Finally, alternative policy options have been simulated: a cash transfer programme targeted to poor children is found to be generally more effective in protecting children than food subsidies. Indeed, with a total budget equivalent to 1% of 2008 GDP, a cash transfer – equivalent to an individual annual amount of 19.8 Cedis – would cut the predicted increase in monetary poverty by over two percentage points in 2011. Although Ghana might be in a position to rapidly implement a cash transfer programme building on the existing Livelihood Empowerment against Poverty (LEAP) programme, other interventions (or mix of policies) might be more cost-effective in the short run. A combination of a universal or regionally targeted cash transfer programmes for children aged 0 to 5 years old, together with a school-feeding programme in poorer regions, might represent an effective way to intervene quickly to improve child well-being.Global economic crisis, child poverty, hunger, education, child labour, health, West and Central Africa, Ghana, social protection

A new formulation of oral viscous budesonide in treating of paediatric eosinophilic oesophagitis: a pilot study

OBJECTIVES: Oral viscous budesonide is a recent therapeutic option for eosinophilic oesophagitis (EoE) compared with dietary restriction and inhaled steroids. This single-centre, open-label, not blinded study aims to evaluate the efficacy and safety of a new, preprepared oral viscous budesonide suspension (PVB) in children and adolescents with EoE. METHODS: We treated 36 children with PVB (29 boys; median age 12 years) with EoE diagnosed according to European Society for Paediatric Gastroenterology Hepatology and Nutrition guidelines. Patients <150 and >150 cm height received 2 and 4 mg PVB daily, respectively, for 12 weeks. Upper gastrointestinal endoscopy was performed at baseline, after 12 weeks of therapy and 24 weeks after the end of therapy. Baseline and post-treatment scores were calculated for symptoms, endoscopy, and histology. Serum cortisol was performed at baseline, 12, and 36 weeks. RESULTS: At the end of PVB trial, endoscopy showed macroscopic remission in 32 patients (88.9%), whereas at histology median pre- and post-treatment peak eosinophil count/high power field (HPF) markedly decreased from 42.2 (range: 15-100) to 2.9 (range: 0-30); moreover, mean symptom and histology scores impressively improved compared with baseline (P < 0.01). At 24 weeks after the end of PVB therapy, endoscopy showed oesophageal relapse in 21 patients (58.3%), whereas 15 (41.7%) were still in remission. Seven children (19.4%) with positive multichannel intraluminal impedance-pH were treated also with proton pump inhibitors. No significant difference between pre-/post-treatment morning cortisol levels occurred. CONCLUSIONS: The new PVB suspension presented in the present study is effective and safe for treating children with proven EoE. Larger placebo-controlled clinical trials would provide more information about dosing, efficacy, and long-term safety of this formulation, specifically designed for the oesophagus

Invasions of the non-indigenous red alga Lophocladia lallemandii (Montagne) F. Schmitz off the Island of Ischia (Tyrrhenian Sea, Italy)

This paper describes the distribution and spread of the non-indigenous red alga Lophocladia lallemandii (Montagne) F. Schmitz along the coast of the Island of Ischia (Tyrrhenian Sea, Italy). Lophocladia lallemandii was monitored through surveys from July 2019 to January 2020 at the Capo Sant’Angelo (Ischia), where L. lallemandii was observed, but not reported, in the years preceding the invasion of the upper rocky infralittoral shore reported here. It is noteworthy that a large portion of the study area is included within one of the two “B no-take” zones of the Marine Protected Area of the “Regno di Nettuno” (“Neptune’s Realm”). During the surveys, the alga was first observed in the middle of July 2019 and totally disappeared by the middle of January 2020. Algal cover showed two peaks in August (55%) and November (58.5%). Fertile thalli (tetrasporophytes) of L. lallemandii were observed in all of the analysed samples. Thalli were not always strongly attached to the substrate or other algae and could often be easily detached by strong hydrodynamic conditions. These detached thalli were found laying on the bottom in dense turfs or floating or stranding on the beach. Noteworthy were the macroflora and fauna, the latter essentially composed by mollusks and amphipods, living among the branches of the alga, and various fishes hiding within the thick algal turf. These observations indicate that this alga may be a source of food and refuge for the native animal community of the upper rocky infralittoral zone

Neopterin is a cerebrospinal fluid marker for treatment outcome evaluation in patients affected by Trypanosoma brucei gambiense sleeping sickness

Background: Post-therapeutic follow-up is essential to confirm cure and to detect early treatment failures in patients affected by sleeping sickness (HAT). Current methods, based on finding of parasites in blood and cerebrospinal fluid (CSF) and counting of white blood cells (WBC) in CSF, are imperfect. New markers for treatment outcome evaluation are needed. We hypothesized that alternative CSF markers, able to diagnose the meningo-encephalitic stage of the disease, could also be useful for the evaluation of treatment outcome. Methodology/Principal findings: Cerebrospinal fluid from patients affected by Trypanosoma brucei gambiense HAT and followed for two years after treatment was investigated. The population comprised stage 2 (S2) patients either cured or experiencing treatment failure during the follow-up. IgM, neopterin, B2MG, MMP-9, ICAM-1, VCAM-1, CXCL10 and CXCL13 were first screened on a small number of HAT patients (n = 97). Neopterin and CXCL13 showed the highest accuracy in discriminating between S2 cured and S2 relapsed patients (AUC 99% and 94%, respectively). When verified on a larger cohort (n = 242), neopterin resulted to be the most efficient predictor of outcome. High levels of this molecule before treatment were already associated with an increased risk of treatment failure. At six months after treatment, neopterin discriminated between cured and relapsed S2 patients with 87% specificity and 92% sensitivity, showing a higher accuracy than white blood cell numbers. Conclusions/Significance: In the present study, neopterin was highlighted as a useful marker for the evaluation of the post-therapeutic outcome in patients suffering from sleeping sickness. Detectable levels of this marker in the CSF have the potential to shorten the follow-up for HAT patients to six months after the end of the treatment

COVID-19-Induced Disruptions of School Feeding Services Exacerbate Food Insecurity in Nigeria

BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic and associated lockdown measures have disrupted educational and nutrition services globally. Understanding the overall and differential impacts of disruption of nutritional (school feeding) services is critical for designing effective post-COVID-19 recovery policies. OBJECTIVES: The aim of this study was to examine the impact of COVID-19-induced disruption of school feeding services on household food security in Nigeria. METHODS: We combined household-level, pre-COVID-19 in-person survey data with postpandemic phone survey data, along with local government area (LGA)–level information on access to school feeding services. We used a difference-in-difference approach and examined temporal trends in the food security of households with and without access to school feeding services. Of the sampled households, 83% live in LGAs with school feeding services. RESULTS: Households experienced an increase in food insecurity in the post-COVID-19 survey round. The share of households skipping a meal increased by 47 percentage points (95% CI: 44–50 percentage points). COVID-19-induced disruptions of school feeding services increased households' experiences of food insecurity, increasing the probability of skipping a meal by 9 percentage points (95% CI: 3–17 percentage points) and the likelihood of going without eating for a whole day by 3 percentage points (95% CI: 2–11 percentage points). Disruption of school feeding services is associated with a 0.2 SD (95% CI: 0.04–0.41 SD) increase in the food insecurity index. Households residing in states experiencing strict lockdown measures reported further deterioration in food insecurity. Single mothers and poorer households experienced relatively larger deteriorations in food security due to disruption of school feeding services. CONCLUSIONS: Our findings show that COVID-19-induced disruptions in educational and nutritional services have exacerbated households’ food insecurity in Nigeria. These findings can inform the designs of immediate and medium-term policy responses, including the designs of social protection policies and alternative programs to substitute nutritional services affected by the pandemic