Maximum likelihood decoding of neuronal inputs from an interspike interval distribution

An expression for the probability distribution of the interspike interval of a leaky integrate-and-fire (LIF) model neuron is rigorously derived, based on recent theoretical developments in the theory of stochastic processes. This enables us to find for the first time a way of developing maximum likelihood estimates (MLE) of the input information (e.g., afferent rate and variance) for an LIF neuron from a set of recorded spike trains. Dynamic inputs to pools of LIF neurons both with and without interactions are efficiently and reliably decoded by applying the MLE, even within time windows as short as 25 msec

Type-I superconductivity in Al6_6Re

While the pure elements tend to exhibit Type-I rather than Type-II superconductivity, nearly all compound superconductors are Type-II, with only a few known exceptions. We report single crystal growth and physical characterization of the rhenium aluminide Al$_6$Re, which we conclude is a Type-I superconductor based on magnetization, ac-susceptibility, and specific-heat measurements. This detection of superconductivity, despite the strong similarity of Al$_6$Re to a family of W and Mo aluminides that do not superconduct, suggests that these aluminides are an ideal testbed for identifying the relative importance of valence electron count and inversion symmetry in determining whether a material will superconduct.Comment: 9 pages, 7 figures, CIF file as ancillar

Secular trend of the leading causes of death in China from 2003 to 2013

Background: To analyze the epidemiological characteristics and secular trends of the leading causes of death in China.Methods: Data on the leading causes of death was collected from the Statistical Yearbook of China. Data for 11 years, from 2003 to 2013, was analyzed by regression analysis and chi-square test.Results: The top 3 causes of death from 2009 to 2013 were cancer, cerebrovascular disease, and cardiopathy, with the role of cardiopathy increasing over time (P<0.01). The proportion of deaths related to cardio-cerebrovascular diseases in urban and rural areas increased to 41.9% and 44.8%, respectively, in 2013, and was significantly higher than that for cancer, 25.5% and 22.4% (both P<0.01). Injury and poisoning in urban or rural areas represented the fifth leading cause of death. In 2006, endocrine, nutritional, and metabolic diseases were the sixth main cause of death, with 3.3% in urban areas. The role of genito-urinary,respiratory, and digestive system diseases in urban areas and genito-urinary system diseases in rural areas decreased during this period (all P<0.05).Conclusion: Cancer, cerebrovascular disease, and cardiopathy accounted for more than 67% of all deaths from 2007 to 2013 in China, and significantly increased in proportion from 2003 to 2013.Keywords: Causes of death; China; cancer; cardiovascular diseas

Unusual double-peak specific heat and spin freezing in a spin-2 triangular lattice antiferromagnet FeAl2_{2}Se4_{4}

We report the properties of a triangular lattice iron-chalcogenide antiferromagnet FeAl$_{2}$Se$_{4}$. The spin susceptibility reveals a significant antiferromagnetic interaction with a Curie-Weiss temperature {\Theta}$_{CW}$ ~ -200K and a spin-2 local moment. Despite a large spin and a large |{\Theta}$_{CW}$|, the low-temperature behaviors are incompatible with conventional classical magnets. No long-range order is detected down to 0.4K. Similar to the well-known spin-1 magnet NiGa$_{2}$S$_{4}$, the specific heat of FeAl$_{2}$Se$_{4}$ exhibits an unusual double-peak structure and a T$^{2}$ power law at low temperatures, which are attributed to the underlying quadrupolar spin correlations and the Halperin-Saslow modes, respectively. The spin freezing occurs at ~ 14K, below which the relaxation dynamics is probed by the ac susceptibility. Our results are consistent with the early theory for the spin-1 system with Heisenberg and biquadratic spin interactions. We argue that the early proposal of the quadrupolar correlation and gauge glass dynamics may be well extended to FeAl$_{2}$Se$_{4}$. Our results provide useful insights about the magnetic properties of frustrated quantum magnets with high spins.Comment: 7 pages, 4 figure

Secular trend of the leading causes of death in China from 2003 to 2013.

Background: To analyze the epidemiological characteristics and secular trends of the leading causes of death in China. Methods: Data on the leading causes of death was collected from the Statistical Yearbook of China. Data for 11 years, from 2003 to 2013, was analyzed by regression analysis and chi-square test. Results: The top 3 causes of death from 2009 to 2013 were cancer, cerebrovascular disease, and cardiopathy, with the role of cardiopathy increasing over time (P<0.01). The proportion of deaths related to cardio-cerebrovascular diseases in urban and rural areas increased to 41.9% and 44.8%, respectively, in 2013, and was significantly higher than that for cancer, 25.5% and 22.4% (both P<0.01). Injury and poisoning in urban or rural areas represented the fifth leading cause of death. In 2006, endocrine, nutritional, and metabolic diseases were the sixth main cause of death, with 3.3% in urban areas. The role of genito-urinary, respiratory, and digestive system diseases in urban areas and genito-urinary system diseases in rural areas decreased during this period (all P<0.05). Conclusion: Cancer, cerebrovascular disease, and cardiopathy accounted for more than 67% of all deaths from 2007 to 2013 in China, and significantly increased in proportion from 2003 to 2013

Five-Year Longitudinal Assessment of the Downstream Impact on Schistosomiasis Transmission following Closure of the Three Gorges Dam

Schistosomiasis, caused by Schistosoma japonicum, is a significant parasitic disease and public health problem in China. How the parasite is transmitted there can be categorized into four distinct modes (modes I–IV) and it is predicted that the Three Gorges Dam, recently completed, will affect the way schistosomiasis is spread in these modes. We monitored transmission for a 5-year period (2002–2006) in eight villages, representative of the three modes (I–III) below the dam across four provinces (Hunan, Jiangxi, Hubei and Anhui) to determine whether there was any immediate impact of the dam on schistosomiasis spread. Human schistosomiasis incidence declined considerably within individual villages and each mode, and the yearly odds ratios (adjusted) for infection risk showed significant downward trends in all three modes over the follow-up period. The decreased human S. japonicum incidence recorded across transmission modes I–III was probably attributable to annual human and bovine praziquantel drug treatment. If an increase in schistosome transmission had occurred as a result of the dam, it would be of negligible size compared with this treatment-induced decline. There had thus been virtually no immediate impact of the TGD on schistosomiasis transmission downstream of the dam over the 5-year surveillance period

Numerical-simulation-based Landslide Warning System and Its Application

Abstract Landslide early warning is a systematic project involving multidisciplinary integration, i.e. geology, mechanics, engineering, monitoring technology, and information technology. When conducting landslide studies, due to the limitation of failure theory of geological body, landslide warning system is purely based on monitoring data nowadays, so it is difficult to integrate interdisciplinary techniques. A trigger condition based prediction theory and disaster stage judgment approach are introduced, with which the landslide time prediction is converted to the disaster stage judgment. The definition and significance of fracture degree is presented, by which the disaster stage judgment is convert to inner fracture state analysis. At last, the numerical-simulation-based landslide warning system is discussed in detail. This system contains four parts, namely parameter acquisition part, disaster kernel analysis system, current state back analysis part, and landslide reliability evaluation part, respectively. In the first part, the essential parameters and its acquisition method is presented, and then the necessity and advantages of dimensional analysis is discussed. In the second part, the new numerical method named continuous discontinuous element method (CDEM) is introduced, and main features, i.e. Lagrange equation, strain strength distribution criteria, element crack strategy, and indented point & indented edge contact model is introduced. In third part, the inverse analysis method of current parameters of geological body based on monitoring data and numerical simulation is discussed. In the fourth part, the reliability evaluation steps are presented in detail. Finally, the sliding occurrence probability of Liangshuijing landslide in Chongqing, China is discussed, which demonstrated to show the precision and rationality of the proposed landslide warning system