Development of a Composite Technique for Preconditioning of 41Cr4 Steel Used as Gear Material: Examination of Its Microstructural Characteristics and Properties

Commercial 41Cr4 (ISO standard) steel was treated by a composite technique. An intermediate layer was introduced firstly at the 41Cr4 steel surface by traditional carburizing and nitriding. Then a hard Cr coating was brush-plated on the intermediate layer. Finally, the coating layer was modified by high current pulsed electron beam (HCPEB), followed by quenching and subsequent tempering treatment. The microstructure, mechanical properties, and fracture behavior were characterized. The results show that a nanocrystalline Cr coating is formed at the 41Cr4 steel surface by the treatment of the new composite technique. Such nanocrystalline Cr coating has acceptable hardness and high corrosion resistance performance, which satisfies the demands of the gears working under high speed and corrosive environment. The composite process proposed in this study is considered as a new prospect method due to the multifunction layer design on the gear surface

Preoperative preparation for Graves’ disease

Thyroidectomy is always regarded as the crucial treatment for Graves’ disease, especially in cases of poor efficacy or excessive side effects of antithyroid- drugs and 131I radioiodine therapy. To decrease the incidence of hemorrhage, thyroid storms and other severe complications during the perioperative period, surgeons explore different therapies to prepare for thyroidectomy. We performed a review of preoperative preparation with a focus on the Graves’ disease population. Most of the previous schemes are effective, which contributes to the smooth operation of patients, but there is no unified standard for preoperative preparation. This review aims to summarize the preoperative preparation of Graves’ disease and the latest developments. Prospective studies with longer follow up-up periods are required to select appropriate preoperative regimens based on personal thyroid statements and to identify target populations of benefit

Environmental geological features of the red clay surrounding rock deformation under the influence of rock-fracture water

The development degree of fissure water in underground rock is a great trouble to the construction of railway tunnel, which will cause a series of environmental geological problems. Take the surrounding rock-section of the typical red clay in Lvliang-Mt. railway tunnel below the underground water level as an example, several aspects about the red clay surrounding rock will be researched, including pore water pressure, volume moisture content, stress of surrounding rock, vault subsidence and horizontal convergence through the field monitoring. Taking into account the importance of railway tunnel engineering, the large shear test of red clay was carried out at the construction site specially and the reliable situ shear strength parameters of surrounding rock will be obtained. These investigations and field tests helped to do a series of work: Three dimensional finite element numerical model of railway tunnel will be established, the deformation law of the red clay surrounding rock will be investigated, respectively, for the water-stress coupling effect and without considering it, the variation of the pore water pressure during excavation, the influence degree about the displacement field and stress field of water-stress coupling on red clay-rock will be discussed and the mechanism of the surrounding rock deformation will be submitted. Finally, the paper puts forward the feasible drainage scheme of the surrounding rock and the tunnel cathode. The geological environment safety of tunnel construction is effectively protected

Study of Alloying Process on 40Cr Surface with Electron Beam after Electroplated Cr Layer

The electroplated hard chromium coat was selected as precoating to improve surface properties of 40Cr. Then electron beam alloying process was experimentalized. The relation rules were summarized between alloying process parameters and overall surface properties by surface morphology observation, surface energy spectrum analysis, EDX analysis in section, and XRD. Experiment results showed that the microcracks appeared on surface of electron beam alloying specimen. Microcracks could disappear when the orthogonal experimental optimum process was used. The matrix metal elements diffused into metal coating surface after electron beam treatment. The maximum depth of alloyed layer could reach 8 μm after electron beam alloying treatment, and electron beam alloying process generated new residual austenite phase

Quantum state transfer between photons preloaded with quantum information

Quantum mechanics provides a ``disembodied'' way to transfer an unknown quantum state from one quantum system to another. However, all experiments of quantum state transfer to date are limited to cases where the target quantum system contains no prior quantum information. Here we propose a scheme for transferring a quantum state to a quantum system preloaded with quantum information. By using an optical qubit-ququart entangling gate, we have experimentally demonstrated this new protocol -- transferring a qubit to a photon preloaded with one qubit of quantum information. After the state transfer, the target photon contains two qubits of quantum information, one from the qubit being transferred and the other from the pre-existing qubit. Furthermore, we have also experimentally realized the inverse operation of the aforementioned quantum state transfer, which is called the partial quantum state transfer, namely transferring one qubit of quantum information from a photon preloaded with two qubits of quantum information to another photon. The fidelities of the quantum state transfer range from $0.700$ to $0.917$, all above the classical limit of $2/3$. Our work sheds light on a new direction for quantum state transfer and demonstrates our ability to implement entangling operations beyond two-level quantum systems.Comment: 22pages, 9 figure

Wireless Power Transfer for Miniature Implantable Biomedical Devices

Miniature implantable electronic devices play increasing roles in modern medicine. In order to implement these devices successfully, the wireless power transfer (WPT) technology is often utilized because it provides an alternative to the battery as the energy source; reduces the size of implant substantially; allows the implant to be placed in a restricted space within the body; reduces both medical cost and chances of complications; and eliminates repeated surgeries for battery replacements. In this work, we present our recent studies on WPT for miniature implants. First, a new implantable coil with a double helix winding is developed which adapts to tubularly shaped organs within the human body, such as blood vessels and nerves. This coil can be made in the planar form and then wrapped around the tubular organ, greatly simplifying the surgical procedure for device implantation. Second, in order to support a variety of experiments (e.g., drug evaluation) using a rodent animal model, we present a special WPT transceiver system with a relatively large power transmitter and a miniature implantable power receiver. We present a multi-coil design that allows steady power transfer from the floor of an animal cage to the bodies of a group of free-moving laboratory rodents

Design of the Firstâ inâ Class, Highly Potent Irreversible Inhibitor Targeting the Meninâ MLL Proteinâ Protein Interaction

The structureâ based design of Mâ 525 as the firstâ inâ class, highly potent, irreversible smallâ molecule inhibitor of the meninâ MLL interaction is presented. Mâ 525 targets cellular menin protein at subâ nanomolar concentrations and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLLâ regulated gene expression in MLL leukemia cells. Mâ 525 demonstrates high cellular specificity over nonâ MLL leukemia cells and is more than 30 times more potent than its corresponding reversible inhibitors. Mass spectrometric analysis and coâ crystal structure of Mâ 525 in complex with menin firmly establish its mode of action. A single administration of Mâ 525 effectively suppresses MLLâ regulated gene expression in tumor tissue. An efficient procedure was developed to synthesize Mâ 525. This study demonstrates that irreversible inhibition of menin may be a promising therapeutic strategy for MLL leukemia.Irreversible inhibitor Mâ 525 targets the meninâ MLL interaction. It is demonstrated that irreversible inhibition of menin is a promising therapeutic strategy for the treatment of MLL leukemia and may have advantages over reversible inhibitors.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141532/1/anie201711828.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141532/2/anie201711828-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141532/3/anie201711828_am.pd

Pyrimido[4,5‐ d ]pyrimidin‐4(1 H )‐one Derivatives as Selective Inhibitors of EGFR Threonine 790 to Methionine 790 (T790M) Mutants

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99673/1/8545_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/99673/2/ange_201302313_sm_miscellaneous_information.pd

Pyrimido[4,5‐ d ]pyrimidin‐4(1 H )‐one Derivatives as Selective Inhibitors of EGFR Threonine 790 to Methionine 790 (T790M) Mutants

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99681/1/8387_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/99681/2/anie_201302313_sm_miscellaneous_information.pd