Secondary Polycythemia May Be an Early Clinical Manifestation of Multiple Myeloma: A Case Report

XiaoLan Li,1 Min Li,2 Juan Tian,1 Zi-Wei Shi,1 Ling-Zhi Wang,2 Kui Song1 1Department of Hematology, The First Affiliated Hospital of Jishou University, Jishou, Hunan, People’s Republic of China; 2Department of Pharmacy, The First Affiliated Hospital of Jishou University, Jishou, Hunan, People’s Republic of ChinaCorrespondence: Kui Song, Department of Hematology, The First Affiliated Hospital of Jishou University, 26 Century Avenue, Qianzhou, Jishou, Hunan, 416000, People’s Republic of China, Email [email protected]: Multiple myeloma (MM) is a malignancy of plasma cells that can cause anemia due to renal failure and bone marrow failure. Secondary polycythemia (SE) is a clinically rare disease that involves the overproduction of red blood cells. To our knowledge, the association of multiple myeloma and polycythemia has been reported, but the association of SE and multiple myeloma is rare and has been infrequently reported in literature. In contrast to anemia, the presence of polycythemia in multiple myeloma patients is a rare finding. A patient of IgA-λ multiple myeloma with secondary erythrocytosis recently admitted to our department is now reported as follows and relevant literature is reviewed to improve clinicians’ awareness of such rare comorbidities.Keywords: multiple myeloma, secondary erythrocytosi

Surface Raman spectroscopic investigation of pyridine adsorption at platinum electrodes - effects of potential and electrolyte

Surface enhanced Raman spectra of pyridine (Py) at Pt electrodes have been investigated as a function of potential and supporting electrolyte. The results show a large difference from those reported for coinage metal electrodes of Ag, Au and Cu, emphasising the effective involvement of chemical enhancement on Pt surfaces. At very negative (or positive) potentials, Raman spectra show the competitive coadsorption of hydrogen (or oxygen-containing species) with Py, and in acidic solutions, PyH+ ions prefer to dissociate into Py adsorbed on Pt surfaces even in the presence of chloride ions. The differences in the surface bonding strength for Py on Pt and coinage metal electrodes are explained in terms of the different electronic configurations of the metals

Three-dimensional micromachining for microsystems by confined etchant layer technique

The micromachining of GaAs with three different truly three-dimensional (3D) molds were performed by the confined etchant layer technique (CELT). The etched patterns were found, approximately, to be the negative copy of the 3D molds. The general comparison of CELT with the existing micromachining techniques, such as two-dimensional (2D) projection lithography and electro-discharge machining, was made. The replication of the complex microstructures down to micrometer scale has been done by CELT in a single step. The photoresist layer, together with the procedures of exposure, developing and removal of resist, could be eliminated. The advantages of CELT over the existing lithography techniques and its potential applications are discussed briefly. It has been shown that CELT could be developed as a complementary technique to the existing micromachining techniques in fabricating microdevices for microsystems. (C) 2001 Elsevier Science Ltd. All rights reserved

An improved accurate monotonicity-preserving scheme for the Euler equations

The accurate monotonicity-preserving (MP) scheme of Suresh and Huynh (1997) [5] is a high-order and high-resolution method for hyperbolic conservation laws. However, the robustness of the MP scheme is not very high. In this paper, a detailed analysis on this scheme is performed, and two potential causes which may account for the weak robustness are revealed. Furthermore, in order to enhance the robustness of the MP scheme, an improved version of the MP scheme is presented, in which a strict continuous total-variation-diminishing (TVD) numerical flux is used at a disturbed discontinuity so that oscillations cannot grow indefinitely without violating the TVD condition. Without destroying the very high resolution property, numerical tests show that the improved scheme shares a strong robustness in simulating extreme numerical tests. (C) 2016 Elsevier Ltd. All rights reserved

Preventing numerical oscillations in the flux-split based finite difference method for compressible flows with discontinuities

In simulating compressible flows with contact discontinuities or material interfaces, numerical pressure and velocity oscillations can be induced by point-wise flux vector splitting (FVS) or component-wise nonlinear difference discretization of convection terms. The current analysis showed that the oscillations are due to the incompatibility of the point-wise splitting of eigenvalues in FVS and the inconsistency of component-wise nonlinear difference discretization among equations of mass, momentum, energy, and even fluid composition for multi-material flows. Two practical principles are proposed to prevent these oscillations: (i) convective fluxes must be split by a global FVS, such as the global Lax-Friedrichs FVS, and (ii) consistent discretization between different equations must be guaranteed. The latter, however, is not compatible with component-wise nonlinear difference discretization. Therefore, a consistent discretization method that uses only one set of common weights is proposed for nonlinear weighted essentially non-oscillatory (WENO) schemes. One possible procedure to determine the common weights is presented that provided good results. The analysis and methods stated above are appropriate for both single- (e.g., contact discontinuity) and multi-material (e.g., material interface) discontinuities. For the latter, however, the additional fluid composition equation should be split and discretized consistently for compatibility with the other equations. Numerical tests including several contact discontinuities and multi-material flows confirmed the effectiveness, robustness, and low computation cost of the proposed method. (C) 2015 Elsevier Inc. All rights reserved

CNx-modified Fe3O4 as Pt nanoparticle support for the oxygen reduction reaction

A novel electrocatalyst support material, nitrogendoped carbon (CNx)-modified Fe3O4 (Fe3O4-CNx), was synthesized through carbonizing a polypyrrole-Fe3O4 hybridized precursor. Subsequently, Fe3O4-CNx-supported Pt (Pt/Fe3O4-CNx) nanocomposites were prepared by reducing Pt precursor in ethylene glycol solution and evaluated for the oxygen reduction reaction (ORR). The Pt/Fe3O4-CNx catalysts were characterized by X-ray diffraction, Raman spectra, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. The electrocatalytic activity and stability of the as-prepared electrocatalysts toward ORR were studied by cyclic voltammetry and steady-state polarization measurements. The results showed that Pt/ Fe3O4-CNx catalysts exhibited superior catalytic performance for ORR to the conventional Pt/C and Pt/C-CNx catalysts.Web of Scienc

Crystalline Gaq3Nanostructures: Preparation, Thermal Property and Spectroscopy Characterization

Crystalline Gaq31-D nanostructures and nanospheres could be fabricated by thermal evaporation under cold trap. The influences of the key process parameters on formation of the nanostructures were also investigated. It has been demonstrated that the morphology and dimension of the nanostructures were mainly controlled by working temperature and working pressure. One-dimensional nanostructures were fabricated at a lower working temperature, whereas nanospheres were formed at a higher working temperature. Larger nanospheres could be obtained when a higher working pressure was applied. The XRD, FTIR, and NMR analyses evidenced that the nanostructures mainly consisted of δ-phase Gaq3. Their DSC trace revealed two small exothermic peaks in addition to the melting endotherm. The one in lower temperature region was ascribed to a transition from δ to β phase, while another in higher temperature region could be identified as a transition from β to δ phase. All the crystalline nanostructures show similar PL spectra due to absence of quantum confinement effect. They also exhibited a spectral blue shift because of a looser interligand spacing and reduced orbital overlap in their δ-phase molecular structures

An Alpha-Catulin Homologue Controls Neuromuscular Function through Localization of the Dystrophin Complex and BK Channels in Caenorhabditis elegans

The large conductance, voltage- and calcium-dependent potassium (BK) channel serves as a major negative feedback regulator of calcium-mediated physiological processes and has been implicated in muscle dysfunction and neurological disorders. In addition to membrane depolarization, activation of the BK channel requires a rise in cytosolic calcium. Localization of the BK channel near calcium channels is therefore critical for its function. In a genetic screen designed to isolate novel regulators of the Caenorhabditis elegans BK channel, SLO-1, we identified ctn-1, which encodes an α-catulin homologue with homology to the cytoskeletal proteins α-catenin and vinculin. ctn-1 mutants resemble slo-1 loss-of-function mutants, as well as mutants with a compromised dystrophin complex. We determined that CTN-1 uses two distinct mechanisms to localize SLO-1 in muscles and neurons. In muscles, CTN-1 utilizes the dystrophin complex to localize SLO-1 channels near L-type calcium channels. In neurons, CTN-1 is involved in localizing SLO-1 to a specific domain independent of the dystrophin complex. Our results demonstrate that CTN-1 ensures the localization of SLO-1 within calcium nanodomains, thereby playing a crucial role in muscles and neurons