Impact of delay on HIV-1 dynamics of fighting a virus with another virus

In this paper, we propose a mathematical model for HIV-1 infection with intracellular delay. The model examines a viral-therapy for controlling infections through recombining HIV-1 virus with a genetically modified virus. For this model, the basic reproduction number $\mathcal{R}_0$ are identified and its threshold properties are discussed. When $\mathcal{R}_0 < 1$, the infection-free equilibrium $E_0$ is globally asymptotically stable. When $\mathcal{R}_0 > 1$, $E_0$ becomes unstable and there occurs the single-infection equilibrium $E_s$, and $E_0$ and $E_s$ exchange their stability at the transcritical point $\mathcal{R}_0 =1$. If $1< \mathcal{R}_0 < R_1$, where $R_1$ is a positive constant explicitly depending on the model parameters, $E_s$ is globally asymptotically stable, while when $\mathcal{R}_0 > R_1$, $E_s$ loses its stability to the double-infection equilibrium $E_d$. There exist a constant $R_2$ such that $E_d$ is asymptotically stable if $R_1<\mathcal R_0 < R_2$, and $E_s$ and $E_d$ exchange their stability at the transcritical point $\mathcal{R}_0 =R_1$. We use one numerical example to determine the largest range of $\mathcal R_0$ for the local stability of $E_d$ and existence of Hopf bifurcation. Some simulations are performed to support the theoretical results. These results show that the delay plays an important role in determining the dynamic behaviour of the system. In the normal range of values, the delay may change the dynamic behaviour quantitatively, such as greatly reducing the amplitudes of oscillations, or even qualitatively changes the dynamical behaviour such as revoking oscillating solutions to equilibrium solutions. This suggests that the delay is a very important fact which should not be missed in HIV-1 modelling

Topological Charge of ADHM Instanton on R^2_{NC}*R^2

We have calculated the topological charge of U(N) instantons on non-degenerate noncommutative space time to be exactly the instanton number k in a previous paper [Mod.Phys.Lett. A18 1691]. This paper, which deals with the degenerate R^2_{NC}*R^2 case, is the continuation of that one. We find that the same conclusion holds in this case, thus complete the answer to the problem of topological charge of noncommutative U(N) instantons.Comment: LaTeX, to appear in Mod. Phys. Lett.

Conformal Symmetry on the Instanton Moduli Space

The conformal symmetry on the instanton moduli space is discussed using the ADHM construction, where a viewpoint of "homogeneous coordinates" for both the spacetime and the moduli space turns out to be useful. It is shown that the conformal algebra closes only up to global gauge transformations, which generalizes the earlier discussion by Jackiw et al. An interesting 5-dimensional interpretation of the SU(2) single-instanton is also mentioned.Comment: 7 pages, LaTeX, version to appear in J. Phys. A: Math. Ge

Doubled Conformal Compactification

We use Weyl transformations between the Minkowski spacetime and dS/AdS spacetime to show that one cannot well define the electrodynamics globally on the ordinary conformal compactification of the Minkowski spacetime (or dS/AdS spacetime), where the electromagnetic field has a sign factor (and thus is discountinuous) at the light cone. This problem is intuitively and clearly shown by the Penrose diagrams, from which one may find the remedy without too much difficulty. We use the Minkowski and dS spacetimes together to cover the compactified space, which in fact leads to the doubled conformal compactification. On this doubled conformal compactification, we obtain the globally well-defined electrodynamics.Comment: 14 pages, 4 figure