19 research outputs found
Nghiên cứu tổng hợp các hybrid mới của artemisinin với zidovudin (AZT)
Get PDFThe synthesis of new hybrids of artemisinin with zidovudin (AZT) was described via six-step procedure. Firstly, the reaction of dihydroartemisinin (2) with NaN3 in the presence of (CH3)3SiCl and a catalytic amount of KI in CH2Cl2 at ice water temperature gave 10β-azidoartemisinin (4). This compound was then hydrolysed by Ph3P in THF/H2O at 65 oC for 6 h to furnish 10β-azidoartemisinin (5). Next, the reaction of 5 with anhydride dicacboxylics (anhydride glutaric, 3,3-dimethyl anhydride glutaric) in the presence of DMAP gave new intermediates 7a,b. Compound 6 was obtained by the reaction of 5 with suberic acid monomethyl ester in CH2Cl2 in the presence of EDC and DMAP at ambient temperature, followed by the hydrolysis in CH2Cl2/EtOH = 9:1 using NaOH 0.2 N. Finally, the reaction of 6 and 7a,b with AZT in CH2Cl2 using EDC and DMAP as a catalytic system afforded novel hybrids 8a-c in moderate yields. The structures of synthesized compounds were confirmed based on spectroscopic methods: IR, NMR and HRMS. Keywords. Artemisinin, dihydroartemisinin, artemether, arteether, sodium azide, hybrid
PHƯƠNG TRÌNH TỈ LƯỢNG HÓA HỌC TRONG NGHIÊN CỨU THỰC NGHIỆM ĐỘNG HỌC PHẢN ỨNG
Get PDFAPPLICATION OF STOICHIOMETRIC EQUATIONS SYSTEM TO INVESTIGATE EXPERIMENTALLY REACTION KINETICS Kinetics of the chemical conversion of carbon used H2O và CO2 was experimentally investigated. Due to analytical abilities, CO and CO2 were chosen as key components. Based on establishing and solving stoichiometric equations, the mass variations of all components in the system were estimated. It allows determining the experimental parameters to give a kinetics description of the reactions
NGHIÊN CỨU SỬ DỤNG CO2 TỪ KHÍ THẢI ĐỐT THAN ĐỂ NUÔI VI TẢO SPIRULINA PLATENSIS
Get PDFUTILIZATION OF CO2 CAPTURED FROM THE COAL-FIRED FLUE GAS FOR GROWING SPIRULINA PLATENSIS SP4 The paper presents the results concerning the utilization of CO2 captured from the coal-fired flue gas for growing the Spirulina platensis SP4 in laboratory condition. Several research results on the conversion of CO32- and HCO3- in algal suspension and CO2 intake efficiency by the alga were presented. The growth and biomass quality of Spirulina platensis SP4 using CO2 from fired-coal flue gas were equivalent to that of the alga grown in the pure CO2 experimental lot
