Syntheses of Some N-Substituted Thiocarbamylpiperidines and Thiocarbamylmorpholines

Syntheses of some N-substituted thiocarbamylpiperidines (I-VIII) and thiocarbamylμiorpholines (IX-XVIII) from piperidine or morpholine and the corresponding isothiocyanaites are described. The substances were tested for their tuberculostatic activity

Syntheses in the 4-Substituted Thiosemicarbazide Series

In connection with the investigations of tuberculostatic activity of arylthiosemicarbazides and arylthiosemicarbazones new 4-substituted thiosemicarbazides (I-XVIII) were synthesized. Condensation of these with aldehydes or ketones afforded the corresponding 4-substituted thiosemicarbazones (XIX-LVI). The attempted \u27acetylation of p-nitrobenzaldehyde-4-phenylthiosemicarbazone and o - chlorobenzaldehyde - 4 - phenylthiosemicarbazone gave besddes acetanilide N,N.-diacetyl-p-nitrobenzylidenhydrazine (LVII) ,and N,N-dia cetyl-chlorobenzylidenehydrazine (LIX) .The 4-substituted thiosemic arbazides and thiosemiearbazones were tested for their tuberculostatic activity

Syntheses in the 4-Substituted Thiosemicarbazide Series

In connection with the investigations of tuberculostatic activity of arylthiosemicarbazides and arylthiosemicarbazones new 4-substituted thiosemicarbazides (I-XVIII) were synthesized. Condensation of these with aldehydes or ketones afforded the corresponding 4-substituted thiosemicarbazones (XIX-LVI). The attempted \u27acetylation of p-nitrobenzaldehyde-4-phenylthiosemicarbazone and o - chlorobenzaldehyde - 4 - phenylthiosemicarbazone gave besddes acetanilide N,N.-diacetyl-p-nitrobenzylidenhydrazine (LVII) ,and N,N-dia cetyl-chlorobenzylidenehydrazine (LIX) .The 4-substituted thiosemic arbazides and thiosemiearbazones were tested for their tuberculostatic activity

Syntheses and Structure of Some 5-Substituted 2,3-Dihydro-1,2,4-triazine-3-thiones

The synthesis of some 5-substituted and 2,5-disubstituted 2,3-dihydro-1,2,4-triazine-3-thiones from arylglyoxals and the corresponding tbiosemicarbazides is described. Prepared were also different S-substituted 5-aryl-3-mercapto-1,2,4-triazines and some reactions of these compounds are described. Comparison of the ultraviolet and infrared spectra of some of these compounds revealed that the first mentioned class of compounds exists in the thione form

Syntheses of Some N-Substituted Thiocarbamylpiperidines and Thiocarbamylmorpholines

Syntheses of some N-substituted thiocarbamylpiperidines (I-VIII) and thiocarbamylμiorpholines (IX-XVIII) from piperidine or morpholine and the corresponding isothiocyanaites are described. The substances were tested for their tuberculostatic activity

Synthesis of Isomeric 3-Aminopyridopyrimidin-4(3H)ones

It could be established that the reaction between hydrazine and enamines, formed from ethyl 2(or 3)-aminopyridine-3(or 2)carboxylates and diethyl ethoxymethylenemalonate or ethyl ethoxymethylenecyanoacetate, afforded 3-aminopyrido(2,3-d)pyrimidin- 4(3H)one or 3-aminopyrido(3,2-d)pyrimidin-4(3H)one, respectively. Similarly, these aminopyridinecarboxylates condense with N,N- dimethylformamide dimethylacetal and react further with hydrazine to give the same bicyclic compounds

Contribution to the Structm·e of 2,5-Dimercapto-1,3,4-thiadiazole and Related Compounds

The structure of 2,5 - dimercapto-1,3,4-thiadiazole and some derivatives was studied from the dependence of UV spectra on pH and H 0 and a monomercapto monodipolar structure is proposed. Evidence was presented tha t addition reactions of 2,5-dimercapto- 1 ,3,4-thiadiazoles on unsaturated systems proceed with the formation of S-akyla ted derivatives involving thus the mercapto group

Contribution to the Structm·e of 2,5-Dimercapto-1,3,4-thiadiazole and Related Compounds

The structure of 2,5 - dimercapto-1,3,4-thiadiazole and some derivatives was studied from the dependence of UV spectra on pH and H 0 and a monomercapto monodipolar structure is proposed. Evidence was presented tha t addition reactions of 2,5-dimercapto- 1 ,3,4-thiadiazoles on unsaturated systems proceed with the formation of S-akyla ted derivatives involving thus the mercapto group

Structure of Some s-Triazoloquinazolinones

Reaction between 3-amino-1,2,4-triazole and 2-carbethoxycyclohexanone can theoretically afford the tricyclic product of the types IV-VII. It was established that the product has structure V and similarly for other cyclization products structures are proposed

Some Derivatives of Perhydro-imidazo(l,5-a)pyridine and Perhydro-pyrrolo(l,2-c)imidazole

Some derivatives o:t perhydro-imidazo(l,5-a)pyridine and -pyrrolo(l,2-c)imidazole were synthesized and a new synthetic route was also developed. This synthesis and other chemical and spectroscopical evidence indicates the structure for these substances with the exo-cyclic sulphur