104 research outputs found
Syntheses of Some N-Substituted Thiocarbamylpiperidines and Thiocarbamylmorpholines
Syntheses of some N-substituted thiocarbamylpiperidines (I-VIII) and thiocarbamylμiorpholines (IX-XVIII) from piperidine or morpholine and the corresponding isothiocyanaites are described. The substances were tested for their tuberculostatic activity
Syntheses in the 4-Substituted Thiosemicarbazide Series
In connection with the investigations of tuberculostatic activity of arylthiosemicarbazides and arylthiosemicarbazones new 4-substituted thiosemicarbazides (I-XVIII) were synthesized. Condensation of these with aldehydes or ketones afforded the corresponding 4-substituted thiosemicarbazones (XIX-LVI). The attempted \u27acetylation of p-nitrobenzaldehyde-4-phenylthiosemicarbazone and o - chlorobenzaldehyde - 4 - phenylthiosemicarbazone gave besddes acetanilide N,N.-diacetyl-p-nitrobenzylidenhydrazine (LVII) ,and N,N-dia cetyl-chlorobenzylidenehydrazine (LIX) .The 4-substituted thiosemic arbazides and thiosemiearbazones were tested for their tuberculostatic activity
Syntheses in the 4-Substituted Thiosemicarbazide Series
In connection with the investigations of tuberculostatic activity of arylthiosemicarbazides and arylthiosemicarbazones new 4-substituted thiosemicarbazides (I-XVIII) were synthesized. Condensation of these with aldehydes or ketones afforded the corresponding 4-substituted thiosemicarbazones (XIX-LVI). The attempted \u27acetylation of p-nitrobenzaldehyde-4-phenylthiosemicarbazone and o - chlorobenzaldehyde - 4 - phenylthiosemicarbazone gave besddes acetanilide N,N.-diacetyl-p-nitrobenzylidenhydrazine (LVII) ,and N,N-dia cetyl-chlorobenzylidenehydrazine (LIX) .The 4-substituted thiosemic arbazides and thiosemiearbazones were tested for their tuberculostatic activity
Syntheses and Structure of Some 5-Substituted 2,3-Dihydro-1,2,4-triazine-3-thiones
The synthesis of some 5-substituted and 2,5-disubstituted
2,3-dihydro-1,2,4-triazine-3-thiones from arylglyoxals and the corresponding tbiosemicarbazides is described. Prepared were also
different S-substituted 5-aryl-3-mercapto-1,2,4-triazines and some
reactions of these compounds are described. Comparison of the
ultraviolet and infrared spectra of some of these compounds
revealed that the first mentioned class of compounds exists in
the thione form
Syntheses of Some N-Substituted Thiocarbamylpiperidines and Thiocarbamylmorpholines
Syntheses of some N-substituted thiocarbamylpiperidines (I-VIII) and thiocarbamylμiorpholines (IX-XVIII) from piperidine or morpholine and the corresponding isothiocyanaites are described. The substances were tested for their tuberculostatic activity
Synthesis of Isomeric 3-Aminopyridopyrimidin-4(3H)ones
It could be established that the reaction between hydrazine
and enamines, formed from ethyl 2(or 3)-aminopyridine-3(or 2)carboxylates and diethyl ethoxymethylenemalonate or ethyl ethoxymethylenecyanoacetate, afforded 3-aminopyrido(2,3-d)pyrimidin-
4(3H)one or 3-aminopyrido(3,2-d)pyrimidin-4(3H)one, respectively.
Similarly, these aminopyridinecarboxylates condense with N,N-
dimethylformamide dimethylacetal and react further with
hydrazine to give the same bicyclic compounds
Contribution to the Structm·e of 2,5-Dimercapto-1,3,4-thiadiazole and Related Compounds
The structure of 2,5 - dimercapto-1,3,4-thiadiazole and some
derivatives was studied from the dependence of UV spectra on
pH and H 0 and a monomercapto monodipolar structure is proposed.
Evidence was presented tha t addition reactions of 2,5-dimercapto-
1 ,3,4-thiadiazoles on unsaturated systems proceed with the formation
of S-akyla ted derivatives involving thus the mercapto
group
Contribution to the Structm·e of 2,5-Dimercapto-1,3,4-thiadiazole and Related Compounds
The structure of 2,5 - dimercapto-1,3,4-thiadiazole and some
derivatives was studied from the dependence of UV spectra on
pH and H 0 and a monomercapto monodipolar structure is proposed.
Evidence was presented tha t addition reactions of 2,5-dimercapto-
1 ,3,4-thiadiazoles on unsaturated systems proceed with the formation
of S-akyla ted derivatives involving thus the mercapto
group
Structure of Some s-Triazoloquinazolinones
Reaction between 3-amino-1,2,4-triazole and 2-carbethoxycyclohexanone
can theoretically afford the tricyclic product of the types IV-VII. It was established that the product has structure V and similarly for other cyclization products structures are proposed
Some Derivatives of Perhydro-imidazo(l,5-a)pyridine and Perhydro-pyrrolo(l,2-c)imidazole
Some derivatives o:t perhydro-imidazo(l,5-a)pyridine and
-pyrrolo(l,2-c)imidazole were synthesized and a new synthetic route
was also developed. This synthesis and other chemical and spectroscopical
evidence indicates the structure for these substances
with the exo-cyclic sulphur
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