Simultaneous Range-Velocity Processing and SNR Analysis of AFIT\u27s Random Noise Radar

This paper presents two research objectives aimed at advancing the AFIT RNR signal processing algorithm and modeling capability toward the overarching goal of performing collision avoidance on an autonomous vehicle. In both research efforts, analytical, simulated, and measured results are provided and used to draw research conclusions. The first research effort is aimed at reducing the memory required for 2D processing in the time domain in order to distribute the processing algorithm across hundreds of processors on a GPU. Distributed processing reduces the overall 2D processing time and the feasibility of a near real-time implementation is studied. The second effort consists of improving a Simulink® model of the AFIT RNR. Each component of the AFIT RNR, as well as the target environment, is modeled and compared to measured results. A robust model will provide a useful tool to study the signal-to-noise ratio (SNR) of the RNR at all points within the radar system

Workshop on Unavoidable Survey Effort Reduction 2 (WKUSER2)

The Workshop on Unavoidable Survey Effort Reduction 2 (WKUSER2) focused on best-available approaches that can minimize information loss and ensure continuity in survey time series when unavoidable changes to survey effort occur. WKUSER2 recognised that reductions, reallocations, or increases in survey effort present similar set of problems, and therefore concentrated on all aspects of survey effort changes. The workshop reviewed available research, current practices, and recommended future directions on four key topics: (i) key elements of flexibility of a survey, (ii) why and how to combine data from different sources (e.g. surveys, fishery sampling) and deal with survey gaps, (iii) how to configure estimation and simulation models, and (iv) review existing tools and technology to evaluate consequences of survey effort changes.Road maps were developed for the key topic areas i, ii, iii, and iv, whenever possible, to assist scientists and survey managers in making decisions on how to evaluate and mitigate the impact of survey effort changes on data and advice quality. Many tools are available or are being developed for that purpose, but the group recognized two important needs during the workshop: i) defining clear objectives and priorities of a survey, which are essential to properly evaluate con- sequences of survey changes; and ii) making all tools accessible, reproducible, and transparent to benefit the whole community. This requires organisational and cultural shift to create support systems that ensure the development and sustainability of such tools in the future

De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia

WD40 repeat-containing proteins form a large family of proteins present in all eukaryotes. Here, we identified five pediatric probands with de novo variants in WDR37, which encodes a member of the WD40 repeat protein family. Two probands shared one variant and the others have variants in nearby amino acids outside the WD40 repeats. The probands exhibited shared phenotypes of epilepsy, colobomas, facial dysmorphology reminiscent of CHARGE syndrome, developmental delay and intellectual disability, and cerebellar hypoplasia. The WDR37 protein is highly conserved in vertebrate and invertebrate model organisms and is currently not associated with a human disease. We generated a null allele of the single Drosophila ortholog to gain functional insights and replaced the coding region of the fly gene CG12333/wdr37 with GAL4. These flies are homozygous viable but display severe bang sensitivity, a phenotype associated with seizures in flies. Additionally, the mutant flies fall when climbing the walls of the vials, suggesting a defect in grip strength, and repeat the cycle of climbing and falling. Similar to wall clinging defect, mutant males often lose grip of the female abdomen during copulation. These phenotypes are rescued by using the GAL4 in the CG12333/wdr37 locus to drive the UAS-human reference WDR37 cDNA. The two variants found in three human subjects failed to rescue these phenotypes, suggesting that these alleles severely affect the function of this protein. Taken together, our data suggest that variants in WDR37 underlie a novel syndromic neurological disorder