Cinnamomum iners as Mitogen-Activated Protein Kinase Kinase (MKK1) inhibitor

Novel inhibitors targeting signal transductions have emerged for cancer therapies. Cinnamomum species have been reported to inhibit the proliferation of various cell lines. In this study, the methanol and acetone extracts of Cinnamomum iner’s leaves demonstrated significant anti-kinase activity against MKK1 in the signal transduction pathway at quantity as low as 1 and 6 mg respectively. Both of the extracts were found to contain polyphenol and flavonoid with potent anti-oxidation activity against DPPH free radicals (IC50=0.2 and 0.3 mg/mL respectively). In conclusion, the extracts may serve as potential MKK1 inhibitors which can be developed into anti-cancer drug

放線菌の潜在的遺伝子クラスターの活性化により発見した新奇ポリケタイドに関する研究

学位の種別: 課程博士審査委員会委員 : （主査）東京大学教授 西山 真, 東京大学教授 松永 茂樹, 東京大学特任教授 尾仲 宏康, 東京大学准教授 作田 庄平, 東京大学准教授 葛山 智久University of Tokyo(東京大学

Microalgae as potential anti-inflammatory natural products against human inflammatory skin diseases

The skin is the first line of defense against pathogen and other environmental pollutant. The body is constantly exposed to reactive oxygen species (ROS) that stimulates inflammatory process in the skin. Many studies have linked ROS to various inflammatory skin diseases. Patients with skin diseases face various challenges with inefficient and inappropriate treatment in managing skin diseases. Overproduction of ROS in the body will result in oxidative stress which will lead to various cellular damage and alter normal cell function. Multiple signaling pathways are seen to have significant effects during ROS-mediated oxidative stress. In this review, microalgae have been selected as a source of natural-derived antioxidant to combat inflammatory skin diseases that are prominent in today's society. Several studies have demonstrated that bioactive compounds isolated from microalgae have anti-inflammation and anti-oxidative properties that can help remedy various skin diseases. These compounds are able to inhibit production of pro-inflammatory cytokines and reduce the expression of inflammatory genes. Bioactive compounds from microalgae work in action by altering enzyme activities, regulating cellular activities, targeting major signaling pathways related to inflammation

Manipulating Steady Heat Conduction by Sensu-shaped Thermal Metamaterials

10.1038/srep10242Scientific Reports