HCC Architecture - Hormonal Communications and Control Architecture

This thesis aims to provide a novel framework for a multiagent system implementation. The major feature of the proposed architecture is the introduction of the biological concept of hormones. The hormones are passed via the communication network to convey limited global system state knowledge. The agents\u27 response to a hormone is interpreted depending on its own local agent state. The primary focus of this thesis is the development of the particulars of the architecture. Prior work of multiagent systems research is reviewed and studied for contributions. Biological studies of hormones are employed to draw out interaction rules and analyze control mechanisms in a biological organism. The hormonal communication and control architecture is constructed, with major components detailed by flowcharts. The proposal is tested with two simulations: A minesweeping problem that has been modeled by other models, and an application of the architecture to a hypothetical ant colony. Research on biological ants is presented to suggest the behavior and goals of a model configured to employ the HCC architecture. The model is fleshed out, and the decisions made by considerations to the architecture are explained. The implementation of the simulation programming with the SWARM programming libraries for the Objective-C language is discussed. The data from experimental runs are analyzed with attention to global action

Nanocomposites and methods for synthesis and use thereof

Nanocomposite compositions and methods of synthesis of the compositions are described. In particular, liquid crystal-functionalized nanoparticles, liquid crystal-templated nanoparticles, nanocomposite compositions including the nanoparticles, and composite compositions including the nanocomposites are detailed.Board of Regents, University of Texas Syste

Context-Dependent Memory under Stressful Conditions: The Case of Skydiving

Two experiments examined the effect of differing levels of emotional arousal on learning and memory for words in matching and mismatching contexts. In Experiment 1, experienced skydivers learned words either in the air or on the ground and recalled them in the same context or in the other context. Experiment 2 replicated the stimuli and design of the first experiment except that participants were shown a skydiving video in lieu of skydiving. Recall was poor in air-learning conditions with actual skydiving, but when lists were learned on land, recall was higher in the matching context than in the mismatching context. In the skydiving video experiment, recall was higher in matching learn-recall contexts regardless of the situation in which learning occurred. We propose that under extremely emotionally arousing circumstances, environmental and/or mood cues are unlikely to become encoded or linked to newly acquired information and thus cannot serve as cues to retrieval. Results can be applied to understanding variations in context-dependent memory in occupations (e.g., police, military special operations, and Special Weapons and Tactics teams) in which the worker experiences considerable emotional stress while learning or recalling new information

Bovine Respiratory Syncytial Virus Infection

Bovine Respiratory Syncytial virus (BRSV) has quickly become one of the major respiratory viruses in cattle in the U.S. Literary reports from various areas of the U.S. and Canada show that BRSV is present in 38 to 81 percent of the beef and dairy cattle tested. Bovine Respiratory Syncytial virus, first isolated in Switzerland in 1970 from an outbreak of respiratory disease involving dairy cattle, is a nonhemagglutinating pneumovirus in the family Paramyxoviridae. The virus was named for its characteristic property of promoting fusion of cells into multinucleated giant cells (syncytial cells)

Protein Arginine Methylation and Citrullination in Epigenetic Regulation

The post-translational modification of arginine residues represents a key mechanism for the epigenetic control of gene expression. Aberrant levels of histone arginine modifications have been linked to the development of several diseases including cancer. In recent years, great progress has been made in understanding the physiological role of individual arginine modifications and their effects on chromatin function. The present review aims to summarize the structural and functional aspects of histone arginine modifying enzymes and their impact on gene transcription. We will discuss the potential for targeting these proteins with small molecules in a variety of disease states

Validating the use of intrinsic markers in body feathers to identify inter-individual differences in non-breeding areas of northern fulmars

Acknowledgments We thank Claire Deacon, Gareth Norton and Andrea Raab for help with laboratory work at the University of Aberdeen, and Barry Thornton and Gillian Martin for running stable isotope analysis at the James Hutton Institute. Thanks to all involved in the collection and processing of dead fulmars through the North Sea plastic pollution project at IMARES, with special thanks to Jens-Kjeld Jensen, Bergur Olsen and Elisa Bravo Rebolledo for samples from the Faroe Islands and Susanne Kühn for those from Iceland. Thanks to Orkney Islands Council for access to Eynhallow and to all the fieldworkers involved in deployment and recovery of the GLS tags. All ringing work was carried out under permit from the BTO, and feather sampling was carried out under licence from the Home Office. We are grateful to James Fox of Migrate Technologies for recovering data from GLS loggers which would not download, and Richard Phillips and Janet Silk of BAS for advice on GLS analysis. We thank Deborah Dawson of the NERC Biomolecular Analysis Facility, University of Sheffield and Stuart Piertney of University of Aberdeen for molecular sexing of the fulmars. Lucy Quinn was supported by a NERC Studentship and additional funding to support fieldwork was gratefully received from Talisman Energy (UK) Ltd. We thank Yves Cherel and two anonymous reviewers for their constructive comments on the manuscript.Peer reviewedPublisher PD

Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination

Protein citrullination is a post-translational modification catalyzed by the protein arginine deiminases (PADs). This modification plays a crucial role in the pathophysiology of numerous autoimmune disorders including RA. Recently, there has been a growing interest in investigating physiological regulators of PAD activity to understand the primary cause of the associated disorders. Apart from calcium, it is well-documented that a reducing environment activates the PADs. Although the concentration of thioredoxin (hTRX), an oxidoreductase that maintains the cellular reducing environment, is elevated in RA patients, its contribution toward RA progression or PAD activity has not been explored. Herein, we demonstrate that hTRX activates PAD4. Kinetic characterization of PAD4 using hTRX as the reducing agent yielded parameters that are comparable to those obtained with a routinely used non-physiological reducing agent, e.g., DTT, suggesting the importance of hTRX in PAD regulation under physiological conditions. Furthermore, we show that various hTRX mutants, including redox inactive hTRX variants, are capable of activating PAD4. This indicates a mechanism that does not require oxidoreductase activity. Indeed, we observed non-covalent interactions between PAD4 and hTRX variants, and propose that these redox-independent interactions are sufficient for hTRX-mediated PAD4 activation

Donated chemical probes for open science

Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and several of these have been made available to academia. However, probe-associated data and control compounds, such as inactive structurally related molecules and their associated data, are generally not accessible. The lack of data and guidance makes it difficult for researchers to decide which chemical tools to choose. Several pharmaceutical companies (AbbVie, Bayer, Boehringer Ingelheim, Janssen, MSD, Pfizer, and Takeda) have therefore entered into a pre-competitive collaboration to make available a large number of innovative high-quality probes, including all probe-associated data, control compounds and recommendations on use (https://openscienceprobes.sgc-frankfurt.de/). Here we describe the chemical tools and target-related knowledge that have been made available, and encourage others to join the project