3,861 research outputs found
Two-Dimensional Bosonization from Variable Shifts in the Path Integral
A method to perform bosonization of a fermionic theory in (1+1) dimensions in
a path integral framework is developed. The method relies exclusively on the
path integral property of allowing variable shifts, and does not depend on the
explicit form of Greens functions. Two examples, the Schwinger model and the
massless Thirring model, are worked out.Comment: 4 page
PMD5 VALUATION OF NEW DRUG APPLICATIONS OF PHARMACEUTICAL COMPANIES USING COMPOUND OPTION MODELS
Can GPR4 be a potential therapeutic target for COVID-19?
This study was supported in part by the North Carolina COVID-19 Special State Appropriations. Research in the author's laboratory was also supported by a grant from the National Institutes of Health (R15DK109484, to LY).Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first emerged in late 2019 and has since rapidly become a global pandemic. SARS-CoV-2 infection causes damages to the lung and other organs. The clinical manifestations of COVID-19 range widely from asymptomatic infection, mild respiratory illness to severe pneumonia with respiratory failure and death. Autopsy studies demonstrate that diffuse alveolar damage, inflammatory cell infiltration, edema, proteinaceous exudates, and vascular thromboembolism in the lung as well as extrapulmonary injuries in other organs represent key pathological findings. Herein, we hypothesize that GPR4 plays an integral role in COVID-19 pathophysiology and is a potential therapeutic target for the treatment of COVID-19. GPR4 is a pro-inflammatory G protein-coupled receptor (GPCR) highly expressed in vascular endothelial cells and serves as a ââŹĹgatekeeperââŹďż˝ to regulate endothelium-blood cell interaction and leukocyte infiltration. GPR4 also regulates vascular permeability and tissue edema under inflammatory conditions. Therefore, we hypothesize that GPR4 antagonism can potentially be exploited to mitigate the hyper-inflammatory response, vessel hyper-permeability, pulmonary edema, exudate formation, vascular thromboembolism and tissue injury associated with COVID-19.ECU Open Access Publishing Support Fun
From paradox to pattern shift: Conceptualising liminal hotspots and their affective dynamics
This article introduces the concept of liminal hotspots as a specifically psychosocial and sociopsychological type of wicked problem, best addressed in a process-theoretical framework. A liminal hotspot is defined as an occasion characterised by the experience of being trapped in the interstitial dimension between different forms-of-process. The paper has two main aims. First, to articulate a nexus of concepts associated with liminal hotspots that together provide general analytic purchase on a wide range of problems concerning âtroubledâ becoming. Second, to provide concrete illustrations through examples drawn from the health domain. In the conclusion, we briefly indicate the sense in which liminal hotspots are part of broader and deeper historical processes associated with changing modes for the management and navigation of liminality
Structural parameterizations for boxicity
The boxicity of a graph is the least integer such that has an
intersection model of axis-aligned -dimensional boxes. Boxicity, the problem
of deciding whether a given graph has boxicity at most , is NP-complete
for every fixed . We show that boxicity is fixed-parameter tractable
when parameterized by the cluster vertex deletion number of the input graph.
This generalizes the result of Adiga et al., that boxicity is fixed-parameter
tractable in the vertex cover number.
Moreover, we show that boxicity admits an additive -approximation when
parameterized by the pathwidth of the input graph.
Finally, we provide evidence in favor of a conjecture of Adiga et al. that
boxicity remains NP-complete when parameterized by the treewidth.Comment: 19 page
Crystallographic structure of ultrathin Fe films on Cu(100)
We report bcc-like crystal structures in 2-4 ML Fe films grown on fcc Cu(100)
using scanning tunneling microscopy. The local bcc structure provides a
straightforward explanation for their frequently reported outstanding magnetic
properties, i.e., ferromagnetic ordering in all layers with a Curie temperature
above 300 K. The non-pseudomorphic structure, which becomes pseudomorphic above
4 ML film thickness is unexpected in terms of conventional rules of thin film
growth and stresses the importance of finite thickness effects in ferromagnetic
ultrathin films.Comment: 4 pages, 3 figures, RevTeX/LaTeX2.0
Creativity, Invention, Innovation and Entrepreneurship, connected in theory separated in practice: - Can we strengthen engineering education by understanding the overlaps and the differences between the four concepts in an educational context
Turning round the telescope. Centre-right parties and immigration and integration policy in Europe
This is an Author's Original Manuscript of 'Turning round the telescope. Centre-right parties and immigration and integration policy in Europe', whose final and definitive form, the Version of Record, has been published in the Journal of European Public Policy 15(3):315-330, 2008 [copyright Taylor & Francis], available online at: http://www.tandfonline.com/doi.org/10.1080/13501760701847341
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