Low-metallicity star formation: Relative impact of metals and magnetic fields

Low-metallicity star formation poses a central problem of cosmology, as it determines the characteristic mass scale and distribution for the first and second generations of stars forming in our Universe. Here, we present a comprehensive investigation assessing the relative impact of metals and magnetic fields, which may both be present during low-metallicity star formation. We show that the presence of magnetic fields generated via the small-scale dynamo stabilises the protostellar disc and provides some degree of support against fragmentation. In the absence of magnetic fields, the fragmentation timescale in our model decreases by a factor of ~10 at the transition from Z=0 to Z>0, with subsequently only a weak dependence on metallicity. Similarly, the accretion timescale of the cluster is set by the large-scale dynamics rather than the local thermodynamics. In the presence of magnetic fields, the primordial disc can become completely stable, therefore forming only one central fragment. At Z>0, the number of fragments is somewhat reduced in the presence of magnetic fields, though the shape of the mass spectrum is not strongly affected in the limits of the statistical uncertainties. The fragmentation timescale, however, increases by roughly a factor of 3 in the presence of magnetic fields. Indeed, our results indicate comparable fragmentation timescales in primordial runs without magnetic fields and Z>0 runs with magnetic fields.Comment: MNRAS in pres

Intracellular compartmentalization of leukotriene synthesis: unexpected nuclear secrets

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/116963/1/feb2s0014579300023747.pd

Social Media and Negative Word of Mouth: Strategies for Handing Unexpecting Comments

Increased usage of social media by consumers impacts businesses that find it necessary to participate to connect with customers. Because social media is conversational in nature, marketers have little control over the message, unlike more traditional forms of marketing communication. The purpose of this paper is to flesh out the tensions that exist as marketers deal with consumer-generated negative social media messages and present possible responses for marketers dealing with this form of negative word of mouth (WOM). Its contribution lies in unpacking options for companies dealing with such negative social media. Case studies and a conceptual model identifying possible strategies for businesses dealing with negative social media attacks are presented. The five general strategies identified are: delay, respond, partner, legal action, and censorship. Understanding and use of these strategies can assist businesses in dealing with negative WOM and can potentially help them protect their brand image and profitability

Homburgvirus LP-018 Has a Unique Ability to Infect Phage-Resistant Listeria monocytogenes

Listeria phage LP-018 is the only phage from a diverse collection of 120 phages able to form plaques on a phage-resistant Listeria monocytogenes strain lacking rhamnose in its cell wall teichoic acids. The aim of this study was to characterize phage LP-018 and to identify what types of mutations can confer resistance to LP-018. Whole genome sequencing and transmission electron microscopy revealed LP-018 to be a member of the Homburgvirus genus. One-step-growth curve analysis of LP-018 revealed an eclipse period of ~60–90 min and a burst size of ~2 PFU per infected cell. Despite slow growth and small burst size, LP-018 can inhibit the growth of Listeria monocytogenes at a high multiplicity of infection. Ten distinct LP-018-resistant mutants were isolated from infected Listeria monocytogenes 10403S and characterized by whole genome sequencing. In each mutant, a single mutation was identified in either the LMRG_00278 or LMRG_01613 encoding genes. Interesting, LP-018 was able to bind to a representative phage-resistant mutant with a mutation in each gene, suggesting these mutations confer resistance through a mechanism independent of adsorption inhibition. Despite forming plaques on the rhamnose deficient 10403S mutant, LP-018 showed reduced binding efficiency, and we did not observe inhibition of the strain under the conditions tested. Two mutants of LP-018 were also isolated and characterized, one with a single SNP in a gene encoding a BppU domain protein that likely alters its host range. LP-018 is shown to be a unique Listeria phage that, with additional evaluation, may be useful in biocontrol applications that aim to reduce the emergence of phage resistance

Halothane hepatitis with renal failure treated with hemodialysis and exchange transfusion

A 38-year-old white female, hepatitis B antigen negative, developed fluminating hepatic failure associated with oliguria and severe azotemia after two halothane anesthesia and without exposure to other hepatotoxic drugs or blood transfusions. She was treated with multiple hemodialysis and exchange blood transfusion. The combined treatment corrected the uremic abnormalities and improved her level of consciousness. The liver and kidney function gradually improved, and she made a complete recovery, the first recorded with hepatic and renal failure under these post-anesthetic conditions. Further evaluation of this combined treatment used for this patient is warranted. © 1974 The Japan Surgical Society

Myocardial aging as a T-cell–mediated phenomenon

In recent years, the myocardium has been rediscovered under the lenses of immunology, and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with different etiologies. Aging is an important risk factor for heart diseases, and it also has impact on the immune system. Thus, we sought to determine whether immunological activity would influence myocardial structure and function in elderly mice. Morphological, functional, and molecular analyses revealed that the age-related myocardial impairment occurs in parallel with shifts in the composition of tissue-resident leukocytes and with an accumulation of activated CD4+ Foxp3- (forkhead box P3) IFN-γ+ T cells in the heart-draining lymph nodes. A comprehensive characterization of different aged immune-deficient mouse strains revealed that T cells significantly contribute to age-related myocardial inflammation and functional decline. Upon adoptive cell transfer, the T cells isolated from the mediastinal lymph node (med-LN) of aged animals exhibited increased cardiotropism, compared with cells purified from young donors or from other irrelevant sites. Nevertheless, these cells caused rather mild effects on cardiac functionality, indicating that myocardial aging might stem from a combination of intrinsic and extrinsic (immunological) factors. Taken together, the data herein presented indicate that heart-directed immune responses may spontaneously arise in the elderly, even in the absence of a clear tissue damage or concomitant infection. These observations might shed new light on the emerging role of T cells in myocardial diseases, which primarily affect the elderly population.info:eu-repo/semantics/publishedVersio