A worldwide correlation of lactase persistence phenotype and genotypes

Background: The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research. Lactase persistence is common in people of European ancestry as well as some African, Middle Eastern and Southern Asian groups, but is rare or absent elsewhere in the world. The recent identification of independent nucleotide changes that are strongly associated with lactase persistence in different populations worldwide has led to the possibility of genetic tests for the trait. However, it is highly unlikely that all lactase persistence-associated variants are known. Using an extensive database of lactase persistence phenotype frequencies, together with information on how those data were collected and data on the frequencies of lactase persistence variants, we present a global summary of the extent to which current genetic knowledge can explain lactase persistence phenotype frequency. Results: We used surface interpolation of Old World lactase persistence genotype and phenotype frequency estimates obtained from all available literature and perform a comparison between predicted and observed trait frequencies in continuous space. By accommodating additional data on sample numbers and known false negative and false positive rates for the various lactase persistence phenotype tests (blood glucose and breath hydrogen), we also apply a Monte Carlo method to estimate the probability that known lactase persistence-associated allele frequencies can explain observed trait frequencies in different regions. Conclusion: Lactase persistence genotype data is currently insufficient to explain lactase persistence phenotype frequency in much of western and southern Africa, southeastern Europe, the Middle East and parts of central and southern Asia. We suggest that further studies of genetic variation in these regions should reveal additional nucleotide variants that are associated with lactase persistence

Psychopathology in police custody: The role of importation, deprivation and interaction models

People experiencing mental illness are over-represented among police cell detainees, however limited work has sought to investigate the occurrence of psychopathology in police custody. The present study sought to examine the predictive power of personal factors (e.g., history of psychiatric hospitalisation), situational factors (e.g., police cell conditions), and their interactive effects to explain the occurrence of psychopathology in police custody. A total of 150 detainees were recruited from two metropolitan police stations in Melbourne, Australia. Personal factors were significantly associated with psychiatric symptomatology, with situational factors and interaction terms yielding no association. Detainees with preexisting vulnerabilities and those unsatisfied with police cell conditions demonstrated the highest levels of psychopathology. While all detainees experience some difficulties in police cells, it is those with pre-existing vulnerabilities that suffer the most. This may be due to the exacerbation of vulnerabilities by police cell conditions. The implications of these findings for provision of health care services in police cells are discussed

Correlates of criminal victimisation among police cell detainees in Victoria, Australia

People with mental illness are more likely to be crime victims than others; however, little is known about the relationship between offending and victimisation among mentally ill offenders. This study investigated the rates and types of victimisation among people detained in police cells (N = 764), with and without histories of mental illness. Those with mental disorders were 1.56 times (95% CI = 1.11–2.17) more likely to be victims of violent crimes than other detainees. Some subgroups of people with mental disorders were not over-represented as victims, raising the possibility that they were less inclined to report certain types of crimes. Implications are discussed with reference to police practice

Bragg spectroscopy with an accelerating Bose-Einstein condensate

We present the results of Bragg spectroscopy performed on an accelerating Bose-Einstein condensate. The Bose condensate undergoes circular micro-motion in a magnetic TOP trap and the effect of this motion on the Bragg spectrum is analyzed. A simple frequency modulation model is used to interpret the observed complex structure, and broadening effects are considered using numerical solutions to the Gross-Pitaevskii equation.Comment: 5 pages, 3 figures, to appear in PRA. Minor changes to text and fig

Bohm's interpretation and maximally entangled states

Several no-go theorems showed the incompatibility between the locality assumption and quantum correlations obtained from maximally entangled spin states. We analyze these no-go theorems in the framework of Bohm's interpretation. The mechanism by which non-local correlations appear during the results of measurements performed on distant parts of entangled systems is explicitly put into evidence in terms of Bohmian trajectories. It is shown that a GHZ like contradiction of the type+1=-1 occurs for well-chosen initial positions of the Bohmian trajectories and that it is this essential non-classical feature that makes it possible to violate the locality condition.Comment: 18 page

World-sheet scattering in AdS_5 x S^5 at two loops

We study the AdS_5 x S^5 sigma-model truncated to the near-flat-space limit to two-loops in perturbation theory. In addition to extending previously known one-loop results to the full SU(2|2)^2 S-matrix we calculate the two-loop correction to the dispersion relation and then compute the complete two-loop S-matrix. The result of the perturbative calculation can be compared with the appropriate limit of the conjectured S-matrix for the full theory and complete agreement is found.Comment: 26pages, 3 figure

Nonergodic Behavior of Interacting Bosons in Harmonic Traps

We study the time evolution of a system of interacting bosons in a harmonic trap. In the low-energy regime, the quantum system is not ergodic and displays rather large fluctuations of the ground state occupation number. In the high energy regime of classical physics we find nonergodic behavior for modest numbers of trapped particles. We give two conditions that assure the ergodic behavior of the quantum system even below the condensation temperature.Comment: 11 pages, 3 PS-figures, uses psfig.st

Reduced sigma-model on AdS_5 x S^5: one-loop scattering amplitudes

We compute one-loop S-matrix in the reduced sigma-model which describes AdS_5 x S^5 string theory in the near-flat-space limit. The result agrees with the corresponding limit of the S-matrix in the full sigma-model, which demonstrates the consistency of the reduction at the quantum level.Comment: 9 pages, 1 figure; v2: reference added; v3: misprint in (3.6) corrected; v4: typo in (3.4) corrected; v5: new form of the actio

General solutions of the Wess-Zumino consistency condition for the Weyl anomalies

The general solutions of the Wess-Zumino consistency condition for the conformal (or Weyl, or trace) anomalies are derived. The solutions are obtained, in arbitrary dimensions, by explicitly computing the cohomology of the corresponding Becchi-Rouet-Stora-Tyutin differential in the space of integrated local functions at ghost number unity. This provides a purely algebraic, regularization-independent classification of the Weyl anomalies in arbitrary dimensions. The so-called type-A anomaly is shown to satisfy a non-trivial descent of equations, similarly to the non-Abelian chiral anomaly in Yang-Mills theory.Comment: 9 pages. RevTeX fil

Steady and Stable: Numerical Investigations of Nonlinear Partial Differential Equations

Excerpt: Mathematics is a language which can describe patterns in everyday life as well as abstract concepts existing only in our minds. Patterns exist in data, functions, and sets constructed around a common theme, but the most tangible patterns are visual. Visual demonstrations can help undergraduate students connect to abstract concepts in advanced mathematical courses. The study of partial differential equations, in particular, benefits from numerical analysis and simulation